Surgical issues after neoadjuvant treatment for gastric cancer

D. D'Ugo, R. Persiani, M. Zoccali, F. Cananzi, V. Vigorita, P. Mazzeo, A. Tufo, Alberto Biondi

Research output: Contribution to journalArticlepeer-review

Abstract

Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior depends on the metastatic potential of the tumour. Particularly, lymphatic metastasis is one of the main predictor of tumour recurrence and survival and current pathologic staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients resected with curative intent. This is deducted by the observation that two thirds of gastric cancers in the western world present at an advanced stage, with nearly 85% of tumors accompanied by lymph node metastasis at diagnosis. To date most therapeutic efforts are directed toward individualization of therapeutic protocols, tailoring the extent of resection integrated by the administration of preoperative and post-operative treatment. The goal of such strategies is to improve prognosis towards the achievement of a curative resection (RO-resection) with minimal morbidity and mortality, with better postoperative quality of life. A brief review of literature about preoperative therapy for gastric carcinoma will be herein illustrated. The rationale and the general drawbacks of preoperative treatments will be both discussed in order to demonstrate its value in terms of safety and efficacy.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalEuropean Review for Medical and Pharmacological Sciences
Volume14
Issue number4
Publication statusPublished - Apr 2010

Keywords

  • Antiblastic therapy
  • Gastric carcinoma
  • Neoadjuvant therapy
  • Preoperative treatment

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

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