Surgical Left Atrial Appendage Exclusion Does Not Impair Left Atrial Contraction Function: A Pilot Study

Gijs E. De Maat, Stefano Benussi, Yoran M. Hummel, Sebastien Krul, Alberto Pozzoli, Antoine H G Driessen, Massimo A. Mariani, Isabelle C. Van Gelder, Wim Jan Van Boven, Joris R. De Groot

Research output: Contribution to journalArticle

Abstract

Background. In order to reduce stroke risk, left atrial appendage amputation (LAAA) is widely adopted in recent years. The effect of LAAA on left atrial (LA) function remains unknown. The objective of present study was to assess the effect of LAAA on LA function. Methods. Sixteen patients with paroxysmal AF underwent thoracoscopic, surgical PVI with LAAA (LAAA group), and were retrospectively matched with 16 patients who underwent the same procedure without LAA amputation (non-LAAA group). To objectify LA function, transthoracic echocardiography with 2D Speckle Tracking was performed before surgery and at 12 months follow-up. Results. Mean age was 57 ± 9 years, 84% were male. Baseline characteristics did not differ significantly except for systolic blood pressure (p=0.005). In both groups, the contractile LA function and LA ejection fraction were not significantly reduced. However, the conduit and reservoir function were significantly decreased at follow-up, compared to baseline. The reduction of strain and strain rate was not significantly different between groups. Conclusions. In this retrospective, observational matched group comparison with a convenience sample size of 16 patients, findings suggest that LAAA does not impair the contractile LA function when compared to patients in which the appendage was unaddressed. However, the LA conduit and reservoir function are reduced in both the LAAA and non-LAAA group. Our data suggest that the LAA can be removed without late LA functional consequences.

Original languageEnglish
Article number318901
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

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Left Atrial Function
Atrial Appendage
Amputation
Echocardiography
Blood pressure
Speckle
Blood Pressure
Surgery
Strain rate
Sample Size
Research Design
Stroke

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

De Maat, G. E., Benussi, S., Hummel, Y. M., Krul, S., Pozzoli, A., Driessen, A. H. G., ... De Groot, J. R. (2015). Surgical Left Atrial Appendage Exclusion Does Not Impair Left Atrial Contraction Function: A Pilot Study. BioMed Research International, 2015, [318901]. https://doi.org/10.1155/2015/318901

Surgical Left Atrial Appendage Exclusion Does Not Impair Left Atrial Contraction Function : A Pilot Study. / De Maat, Gijs E.; Benussi, Stefano; Hummel, Yoran M.; Krul, Sebastien; Pozzoli, Alberto; Driessen, Antoine H G; Mariani, Massimo A.; Van Gelder, Isabelle C.; Van Boven, Wim Jan; De Groot, Joris R.

In: BioMed Research International, Vol. 2015, 318901, 2015.

Research output: Contribution to journalArticle

De Maat, GE, Benussi, S, Hummel, YM, Krul, S, Pozzoli, A, Driessen, AHG, Mariani, MA, Van Gelder, IC, Van Boven, WJ & De Groot, JR 2015, 'Surgical Left Atrial Appendage Exclusion Does Not Impair Left Atrial Contraction Function: A Pilot Study', BioMed Research International, vol. 2015, 318901. https://doi.org/10.1155/2015/318901
De Maat, Gijs E. ; Benussi, Stefano ; Hummel, Yoran M. ; Krul, Sebastien ; Pozzoli, Alberto ; Driessen, Antoine H G ; Mariani, Massimo A. ; Van Gelder, Isabelle C. ; Van Boven, Wim Jan ; De Groot, Joris R. / Surgical Left Atrial Appendage Exclusion Does Not Impair Left Atrial Contraction Function : A Pilot Study. In: BioMed Research International. 2015 ; Vol. 2015.
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