Surgical Management of Advanced Pancreatic Neuroendocrine Tumors: Short-Term and Long-Term Results from an International Multi-institutional Study

David Jérémie Birnbaum, Olivier Turrini, Luca Vigano, Nadia Russolillo, Aurélie Autret, Vincent Moutardier, Lorenzo Capussotti, Yves Patrice Le Treut, Jean Robert Delpero, Jean Hardwigsen

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The role of extended resections in the management of advanced pancreatic neuroendocrine tumors (PNETs) is not well defined.

Methods: Between 1995 and 2012, 134 patients with PNET underwent isolated (isoPNET group: 91 patients) or extended pancreatic resection (synchronous liver metastases and/or adjacent organs) (advPNET group: 43 patients).

Results: The associated resections included 27 hepatectomies, 9 vascular resections, 12 colectomies, 10 gastrectomies, 4 nephrectomies, 4 adrenalectomies, and 3 duodenojejunal resections. R0 was achieved in 41 patients (95 %) in the advPNET. The rates of T3–T4 (73 vs 16 %; p 

Conclusions: An aggressive surgical approach for locally advanced or metastatic tumors is safe and offers long-term survival.

Original languageEnglish
Pages (from-to)1000-1007
Number of pages8
JournalAnnals of Surgical Oncology
Volume22
Issue number3
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Surgery
  • Oncology
  • Medicine(all)

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