Background: The role of extended resections in the management of advanced pancreatic neuroendocrine tumors (PNETs) is not well defined.
Methods: Between 1995 and 2012, 134 patients with PNET underwent isolated (isoPNET group: 91 patients) or extended pancreatic resection (synchronous liver metastases and/or adjacent organs) (advPNET group: 43 patients).
Results: The associated resections included 27 hepatectomies, 9 vascular resections, 12 colectomies, 10 gastrectomies, 4 nephrectomies, 4 adrenalectomies, and 3 duodenojejunal resections. R0 was achieved in 41 patients (95 %) in the advPNET. The rates of T3–T4 (73 vs 16 %; p
Conclusions: An aggressive surgical approach for locally advanced or metastatic tumors is safe and offers long-term survival.
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