Surgical Management of Advanced Pancreatic Neuroendocrine Tumors: Short-Term and Long-Term Results from an International Multi-institutional Study

David Jérémie Birnbaum; Olivier Turrini; Luca Vigano; Nadia Russolillo; Aurélie Autret; Vincent Moutardier; Lorenzo Capussotti; Yves Patrice Le Treut; Jean Robert Delpero; Jean Hardwigsen

doi:10.1245/s10434-014-4016-8

Surgical Management of Advanced Pancreatic Neuroendocrine Tumors: Short-Term and Long-Term Results from an International Multi-institutional Study

David Jérémie Birnbaum, Olivier Turrini, Luca Vigano, Nadia Russolillo, Aurélie Autret, Vincent Moutardier, Lorenzo Capussotti, Yves Patrice Le Treut, Jean Robert Delpero, Jean Hardwigsen

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The role of extended resections in the management of advanced pancreatic neuroendocrine tumors (PNETs) is not well defined.

Methods: Between 1995 and 2012, 134 patients with PNET underwent isolated (isoPNET group: 91 patients) or extended pancreatic resection (synchronous liver metastases and/or adjacent organs) (advPNET group: 43 patients).

Results: The associated resections included 27 hepatectomies, 9 vascular resections, 12 colectomies, 10 gastrectomies, 4 nephrectomies, 4 adrenalectomies, and 3 duodenojejunal resections. R0 was achieved in 41 patients (95 %) in the advPNET. The rates of T3–T4 (73 vs 16 %; p

Conclusions: An aggressive surgical approach for locally advanced or metastatic tumors is safe and offers long-term survival.

Original language	English
Pages (from-to)	1000-1007
Number of pages	8
Journal	Annals of Surgical Oncology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1245/s10434-014-4016-8
Publication status	Published - 2015

ASJC Scopus subject areas

Surgery
Oncology
Medicine(all)

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Birnbaum, D. J., Turrini, O., Vigano, L., Russolillo, N., Autret, A., Moutardier, V., Capussotti, L., Le Treut, Y. P., Delpero, J. R., & Hardwigsen, J. (2015). Surgical Management of Advanced Pancreatic Neuroendocrine Tumors: Short-Term and Long-Term Results from an International Multi-institutional Study. Annals of Surgical Oncology, 22(3), 1000-1007. https://doi.org/10.1245/s10434-014-4016-8

Surgical Management of Advanced Pancreatic Neuroendocrine Tumors : Short-Term and Long-Term Results from an International Multi-institutional Study. / Birnbaum, David Jérémie; Turrini, Olivier; Vigano, Luca; Russolillo, Nadia; Autret, Aurélie; Moutardier, Vincent; Capussotti, Lorenzo; Le Treut, Yves Patrice; Delpero, Jean Robert; Hardwigsen, Jean.

In: Annals of Surgical Oncology, Vol. 22, No. 3, 2015, p. 1000-1007.

Research output: Contribution to journal › Article › peer-review

Birnbaum, DJ, Turrini, O, Vigano, L, Russolillo, N, Autret, A, Moutardier, V, Capussotti, L, Le Treut, YP, Delpero, JR & Hardwigsen, J 2015, 'Surgical Management of Advanced Pancreatic Neuroendocrine Tumors: Short-Term and Long-Term Results from an International Multi-institutional Study', Annals of Surgical Oncology, vol. 22, no. 3, pp. 1000-1007. https://doi.org/10.1245/s10434-014-4016-8

Birnbaum, David Jérémie ; Turrini, Olivier ; Vigano, Luca ; Russolillo, Nadia ; Autret, Aurélie ; Moutardier, Vincent ; Capussotti, Lorenzo ; Le Treut, Yves Patrice ; Delpero, Jean Robert ; Hardwigsen, Jean. / Surgical Management of Advanced Pancreatic Neuroendocrine Tumors : Short-Term and Long-Term Results from an International Multi-institutional Study. In: Annals of Surgical Oncology. 2015 ; Vol. 22, No. 3. pp. 1000-1007.

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abstract = "Background: The role of extended resections in the management of advanced pancreatic neuroendocrine tumors (PNETs) is not well defined.Methods: Between 1995 and 2012, 134 patients with PNET underwent isolated (isoPNET group: 91 patients) or extended pancreatic resection (synchronous liver metastases and/or adjacent organs) (advPNET group: 43 patients).Results: The associated resections included 27 hepatectomies, 9 vascular resections, 12 colectomies, 10 gastrectomies, 4 nephrectomies, 4 adrenalectomies, and 3 duodenojejunal resections. R0 was achieved in 41 patients (95 %) in the advPNET. The rates of T3–T4 (73 vs 16 %; p Conclusions: An aggressive surgical approach for locally advanced or metastatic tumors is safe and offers long-term survival.",

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