Surgical management of neuroendocrine tumors

Domenico Tamburrino, Gabriele Spoletini, Stefano Partelli, Francesca Muffatti, Olga Adamenko, Stefano Crippa, Massimo Falconi

Research output: Contribution to journalArticle

Abstract

During the last decades an increase in the incidence of neuroendocrine tumors (NETs) was observed. Gastroenteropancreatic NETs represent the majority of NETs. Compared with their epithelial counterpart they usually have a more indolent behaviour and surgical resection improves survival. Tumor diameter is one of the main parameter in the decision making process for nonfunctioning forms. Generally, small lesions can be treated conservatively whereas larger tumors should be treated with standard surgical resection and lymphadenectomy. Functioning tumors should be resected regardless the dimension of the lesion. Locally advanced and metastatic disease should be also treated with extended resections, keeping in consideration the grading, size, Ki67, and presence of extra-abdominal disease. In the case of metastases the panel of operative treatment includes resection, ablation, up to liver transplantation.

Original languageEnglish
Pages (from-to)93-102
Number of pages10
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Neuroendocrine Tumors
Neoplasms
Lymph Node Excision
Liver Transplantation
Decision Making
Neoplasm Metastasis
Incidence
Therapeutics

Keywords

  • carcinoid
  • liver metastases
  • MEN 1
  • neuroendocrine tumors
  • surgery

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Tamburrino, D., Spoletini, G., Partelli, S., Muffatti, F., Adamenko, O., Crippa, S., & Falconi, M. (2016). Surgical management of neuroendocrine tumors. Best Practice and Research: Clinical Endocrinology and Metabolism, 30(1), 93-102. https://doi.org/10.1016/j.beem.2015.10.003

Surgical management of neuroendocrine tumors. / Tamburrino, Domenico; Spoletini, Gabriele; Partelli, Stefano; Muffatti, Francesca; Adamenko, Olga; Crippa, Stefano; Falconi, Massimo.

In: Best Practice and Research: Clinical Endocrinology and Metabolism, Vol. 30, No. 1, 01.01.2016, p. 93-102.

Research output: Contribution to journalArticle

Tamburrino, D, Spoletini, G, Partelli, S, Muffatti, F, Adamenko, O, Crippa, S & Falconi, M 2016, 'Surgical management of neuroendocrine tumors', Best Practice and Research: Clinical Endocrinology and Metabolism, vol. 30, no. 1, pp. 93-102. https://doi.org/10.1016/j.beem.2015.10.003
Tamburrino D, Spoletini G, Partelli S, Muffatti F, Adamenko O, Crippa S et al. Surgical management of neuroendocrine tumors. Best Practice and Research: Clinical Endocrinology and Metabolism. 2016 Jan 1;30(1):93-102. https://doi.org/10.1016/j.beem.2015.10.003
Tamburrino, Domenico ; Spoletini, Gabriele ; Partelli, Stefano ; Muffatti, Francesca ; Adamenko, Olga ; Crippa, Stefano ; Falconi, Massimo. / Surgical management of neuroendocrine tumors. In: Best Practice and Research: Clinical Endocrinology and Metabolism. 2016 ; Vol. 30, No. 1. pp. 93-102.
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