Surgical margins in oral squamous cell cancer: Intraoperative evaluation and prognostic impact

Giuditta Mannelli, Lara Valentina Comini, Cesare Piazza

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose of reviewTo summarize recent findings regarding surgical management of oral squamous cell cancer (OSCC) through analysis of different intraoperative techniques for assessment of margins, evaluate the pros and cons of each, and ensuing prognostic impact.Recent findings'En bloc' OSCC resection and histopathologic evaluation of margins on the formalin-fixed specimen remain the 'gold standard' for oral oncologic surgery, whereas assessment of intraoperative surgical margins and its overall clinical value are still questioned and debated in the literature. The commonly applied evaluation of frozen sections still raises concerns regarding its efficacy and reproducibility; therefore, several ancillary diagnostic methods have entered the field of head and neck oncology in the last decades, aiming to support the surgeon in achieving tumor-free margins during ablative procedures.SummaryPoor prognosis of OSCC is strongly associated with residual tumor after surgery. Negative surgical margins are one of the strongest prognosticators for disease-free survival and locoregional control, but their intraoperative determination seems still to be suboptimal and needs better refinement. The most studied techniques to assess intraoperative margins include fluorescence, Raman spectroscopy, narrow band imaging, optical coherence tomography, and cytological bone margins analysis; each has its unique characteristics that are described in detail herein.

Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Volume27
Issue number2
DOIs
Publication statusPublished - Apr 1 2019

Fingerprint

Squamous Cell Neoplasms
Mouth Neoplasms
Narrow Band Imaging
Raman Spectrum Analysis
Oral Surgery
Fluorescence Spectrometry
Optical Coherence Tomography
Residual Neoplasm
Frozen Sections
Formaldehyde
Disease-Free Survival
Neck
Head
Bone and Bones
Margins of Excision

Keywords

  • intraoperative assessment
  • margin
  • oncologic outcomes
  • oral cancer
  • surgery

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Surgical margins in oral squamous cell cancer : Intraoperative evaluation and prognostic impact. / Mannelli, Giuditta; Comini, Lara Valentina; Piazza, Cesare.

In: Current Opinion in Otolaryngology and Head and Neck Surgery, Vol. 27, No. 2, 01.04.2019, p. 98-103.

Research output: Contribution to journalReview article

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