Surgical resection for intractable epilepsy in "double cortex" syndrome yields inadequate results

A. Bernasconi, V. Martinez, P. Rosa-Neto, D. D'Agostino, N. Bernasconi, S. Berkovic, M. MacKay, A. Simon Harvey, A. Palmini, J. Costa Da Costa, Eliseu Paglioli, H. I. Kim, M. Connolly, A. Olivier, F. Dubeau, E. Andermann, R. Guerrini, W. Whisler, L. De Toledo-Morrell, F. MorrellF. Andermann

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To analyze the results of surgical treatment of intractable epilepsy in patients with subcortical band heterotopia, or double cortex syndrome, a diffuse neuronal migration disorder. Methods: We studied eight patients (five women) with double cortex syndrome and intractable epilepsy. All had a comprehensive presurgical evaluation including prolonged video-EEG recordings and magnetic resonance imaging (MRI). Results: All patients had partial seizures, with secondary generalization in six of them. Neurologic examination was normal in all. Three were of normal intelligence, and five were mildly retarded. Six patients underwent invasive EEG recordings, three of them with subdural grids and three with stereotactic implanted depth electrodes (SEEG). Although EEG recordings showed multilobar epileptic abnormalities in most patients, regional or focal seizure onset was recorded in all. MRI showed bilateral subcortical band heterotopia, asymmetric in thickness in three. An additional area of cortical thickening in the left frontal lobe was found in one patient. Surgical procedures included multiple subpial transections in two patients, frontal lesionectomy in one, temporal lobectomy with amygdalohippocampectomy in five, and an additional anterior callosotomy in one. Five patients had no significant improvement, two had some improvement, and one was greatly improved. Conclusion: Our results do not support focal surgical removal of epileptogenic tissue in patients with double cortex syndrome, even in the presence of a relatively localized epileptogenic area.

Original languageEnglish
Pages (from-to)1124-1129
Number of pages6
JournalEpilepsia
Volume42
Issue number9
DOIs
Publication statusPublished - 2001

Keywords

  • Double cortex
  • Intractable epilepsy
  • MRI
  • Subcortical band heterotopia
  • Surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Surgical resection for intractable epilepsy in "double cortex" syndrome yields inadequate results'. Together they form a unique fingerprint.

Cite this