Surgical results in microadenomas.

M. Giovanelli, M. Losa, P. Mortini, S. Acerno, E. Giugni

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Pituitary microadenomas are small tumors whose maximal diameter is less than 1 cm. The aim of surgical removal of microadenomas should be not only the reversal of hormone hypersecretion but also the preservation of normal anterior pituitary function. Our series includes 230 patients with a microadenoma who had their first operation in our department: 45 were GH-secreting, 92 were PRL-secreting, 90 were ACTH-secreting, and 3 were TSH-secreting. Remission of disease was achieved in 81%, 77%, 91%, and 100% of GH-, PRL-, ACTH-, and TSH-secreting adenomas, respectively. There was no perioperative mortality and only 5 patients experienced a major complication. A total of 7 patients had diabetes insipidus for at least 6 months after operation. Hypopituitarism, not present in any patients before operation, developed in 3.5% of the cases. Our experience confirms that patients with microadenomas have the best chances of a successful operation. Since tumor size should gradually increase with time, we underscore the need of early diagnosis and treatment in patients with pituitary adenomas.

Original languageEnglish
Pages (from-to)11-12
Number of pages2
JournalActa Neurochirurgica, Supplement
Volume65
Publication statusPublished - 1996

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Adrenocorticotropic Hormone
Hypopituitarism
Diabetes Insipidus
Pituitary Neoplasms
Adenoma
Early Diagnosis
Neoplasms
Hormones
Mortality
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Giovanelli, M., Losa, M., Mortini, P., Acerno, S., & Giugni, E. (1996). Surgical results in microadenomas. Acta Neurochirurgica, Supplement, 65, 11-12.

Surgical results in microadenomas. / Giovanelli, M.; Losa, M.; Mortini, P.; Acerno, S.; Giugni, E.

In: Acta Neurochirurgica, Supplement, Vol. 65, 1996, p. 11-12.

Research output: Contribution to journalArticle

Giovanelli, M, Losa, M, Mortini, P, Acerno, S & Giugni, E 1996, 'Surgical results in microadenomas.', Acta Neurochirurgica, Supplement, vol. 65, pp. 11-12.
Giovanelli, M. ; Losa, M. ; Mortini, P. ; Acerno, S. ; Giugni, E. / Surgical results in microadenomas. In: Acta Neurochirurgica, Supplement. 1996 ; Vol. 65. pp. 11-12.
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