Surgical site infections following colorectal cancer surgery: A randomized prospective trial comparing common and advanced antimicrobial dressing containing ionic silver

Roberto Biffi, Luca Fattori, Emilio Bertani, Davide Radice, Nicole Rotmensz, Pasquale Misitano, Sabine Cenciarelli, Antonio Chiappa, Liliana Tadini, Marina Mancini, Giovanni Pesenti, Bruno Andreoni, Angelo Nespoli

Research output: Contribution to journalArticle

Abstract

Background: An antimicrobial dressing containing ionic silver was found effective in reducing surgical-site infection in a preliminary study of colorectal cancer elective surgery. We decided to test this finding in a randomized, double-blind trial.Methods: Adults undergoing elective colorectal cancer surgery at two university-affiliated hospitals were randomly assigned to have the surgical incision dressed with Aquacel® Ag Hydrofiber dressing or a common dressing. To blind the patient and the nursing and medical staff to the nature of the dressing used, scrub nurses covered Aquacel® Ag Hydrofiber with a common wound dressing in the experimental arm, whereas a double common dressing was applied to patients of control group. The primary end-point of the study was the occurrence of any surgical-site infection within 30 days of surgery.Results: A total of 112 patients (58 in the experimental arm and 54 in the control group) qualified for primary end-point analysis. The characteristics of the patient population and their surgical procedures were similar. The overall rate of surgical-site infection was lower in the experimental group (11.1% center 1, 17.5% center 2; overall 15.5%) than in controls (14.3% center 1, 24.2% center 2, overall 20.4%), but the observed difference was not statistically significant (P = 0.451), even with respect to surgical-site infection grade 1 (superficial) versus grades 2 and 3, or grade 1 and 2 versus grade 3.Conclusions: This randomized trial did not confirm a statistically significant superiority of Aquacel® Ag Hydrofiber dressing in reducing surgical-site infection after elective colorectal cancer surgery.Trial registration: Clinicaltrials.gov: NCT00981110.

Original languageEnglish
Article number94
JournalWorld Journal of Surgical Oncology
Volume10
DOIs
Publication statusPublished - May 23 2012

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Surgical Wound Infection
Colorectal Surgery
Bandages
Silver
Colorectal Neoplasms
Carboxymethylcellulose Sodium
Control Groups
Nursing Staff
Medical Staff
Population Characteristics
Ambulatory Surgical Procedures
Nurses
Wounds and Injuries

Keywords

  • Colorectal cancer
  • Elective surgery
  • Hydrofiber dressing
  • Ionic silver
  • Surgical site infection

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Surgical site infections following colorectal cancer surgery : A randomized prospective trial comparing common and advanced antimicrobial dressing containing ionic silver. / Biffi, Roberto; Fattori, Luca; Bertani, Emilio; Radice, Davide; Rotmensz, Nicole; Misitano, Pasquale; Cenciarelli, Sabine; Chiappa, Antonio; Tadini, Liliana; Mancini, Marina; Pesenti, Giovanni; Andreoni, Bruno; Nespoli, Angelo.

In: World Journal of Surgical Oncology, Vol. 10, 94, 23.05.2012.

Research output: Contribution to journalArticle

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abstract = "Background: An antimicrobial dressing containing ionic silver was found effective in reducing surgical-site infection in a preliminary study of colorectal cancer elective surgery. We decided to test this finding in a randomized, double-blind trial.Methods: Adults undergoing elective colorectal cancer surgery at two university-affiliated hospitals were randomly assigned to have the surgical incision dressed with Aquacel{\circledR} Ag Hydrofiber dressing or a common dressing. To blind the patient and the nursing and medical staff to the nature of the dressing used, scrub nurses covered Aquacel{\circledR} Ag Hydrofiber with a common wound dressing in the experimental arm, whereas a double common dressing was applied to patients of control group. The primary end-point of the study was the occurrence of any surgical-site infection within 30 days of surgery.Results: A total of 112 patients (58 in the experimental arm and 54 in the control group) qualified for primary end-point analysis. The characteristics of the patient population and their surgical procedures were similar. The overall rate of surgical-site infection was lower in the experimental group (11.1{\%} center 1, 17.5{\%} center 2; overall 15.5{\%}) than in controls (14.3{\%} center 1, 24.2{\%} center 2, overall 20.4{\%}), but the observed difference was not statistically significant (P = 0.451), even with respect to surgical-site infection grade 1 (superficial) versus grades 2 and 3, or grade 1 and 2 versus grade 3.Conclusions: This randomized trial did not confirm a statistically significant superiority of Aquacel{\circledR} Ag Hydrofiber dressing in reducing surgical-site infection after elective colorectal cancer surgery.Trial registration: Clinicaltrials.gov: NCT00981110.",
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AU - Biffi, Roberto

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AU - Radice, Davide

AU - Rotmensz, Nicole

AU - Misitano, Pasquale

AU - Cenciarelli, Sabine

AU - Chiappa, Antonio

AU - Tadini, Liliana

AU - Mancini, Marina

AU - Pesenti, Giovanni

AU - Andreoni, Bruno

AU - Nespoli, Angelo

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