Surgical spacer placement prior carbon ion radiotherapy (CIRT): An effective feasible strategy to improve the treatment for sacral chordoma

Lorenzo Cobianchi, Andrea Peloso, Barbara Vischioni, Denis Panizza, Maria Rosaria Fiore, Piero Fossati, Viviana Vitolo, Alberto Iannalfi, Mario Ciocca, Silvia Brugnatelli, Tommaso Dominioni, Dario Bugada, Marcello Maestri, Mario Alessiani, Francesca Valvo, Roberto Orecchia, Paolo Dionigi

Research output: Contribution to journalArticle

Abstract

Background: Sacral chordoma (SC) is a neoplasm arising from residual notochordal cells degeneration. SC is difficult to manage mainly because of anatomic location and tendency to extensive spread. Carbon ion radiotherapy (CIRT) is highly precise to selectively deliver high biological effective dose to the tumor target sparing the anatomical structure on its path even if when SC is contiguous to the intestine, and a surgical spacer might be an advantageous tool to create a distance around the target volume allowing radical curative dose delivery with a safe dose gradient to the surrounding organs. This paper describes a double approach-open and hand-assisted laparoscopic-for a silicon spacer placement in patients affected by sacral chordoma undergoing carbon ion radiotherapy. Methods: Six consecutive patients have been enrolled for surgical spacer placement-open (three) or hand-assisted (three)-prior carbon ion radiotherapy treatment in order to increase efficacy of carbon ion radiotherapy minimizing its side effects. Results: Results showed that silicon spacer placement for SC treatment is feasible both via laparoscopic and laparotomic approach. Conclusions: Its use might improve CIRT safety and thus efficacy for SC treatment.

Original languageEnglish
Article number211
JournalWorld Journal of Surgical Oncology
Volume14
Issue number1
DOIs
Publication statusPublished - Aug 9 2016

Keywords

  • Carbon ion radiotherapy
  • Chordoma
  • Spacer placement

ASJC Scopus subject areas

  • Surgery
  • Oncology

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