Surgical Techniques for Diaphragmatic Resection during Cytoreduction in Advanced or Recurrent Ovarian Carcinoma: A Systematic Review and Meta-analysis

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Abstract

Objective Optimal cytoreduction is one the main factors improving survival outcomes in patients affected by ovarian cancer (OC). It is estimated that approximately 40% of OC patients have gross disease located on the diaphragm. However, no mature data evaluating outcomes of surgical techniques for the management of diaphragmatic carcinosis exist. In the present study, we aimed to estimate surgery-related morbidity of different surgical techniques for diaphragmatic cytoreduction in advanced or recurrent OC. Methods PubMed (MEDLINE), Web of Science, and Clincaltrials.gov databases were searched for records estimating outcomes of diaphragmatic peritoneal stripping (DPS) or diaphragmatic full-thickness resection (DFTR) for OC. The meta-analysis was performed using the Cochrane Review software. Results For the final analysis, 5 articles were available, including 272 patients. Diaphragmatic peritoneal stripping and DFTR were performed in 197 patients (72%) and 75 patients (28%), respectively. Pooled analysis suggested that the estimated pleural effusion rate was 43% and 51% after DPS and DFTR, respectively. The need for pleural punctures or chest tube placement was 4% and 9% after DPS and DFTR, respectively. The rate of postoperative pneumothorax (4% vs 9%; odds ratio, 0.31; 95% confidence interval, 0.05-2.08) and subdiaphragmatic abscess (3% vs 3%; odds ratio, 0.45; 95% confidence interval, 0.09-2.31) were similar after the execution of DPS and DFTR. Conclusions Diaphragmatic surgery is a crucial step during cytoreduction for advanced or recurrent OC. Obviously, the choice to perform DPS or DFTR depends on the infiltration of the diaphragmatic muscle or not. Both the procedures are associated with a low pulmonary complication and chest tube placement rates.

Original languageEnglish
Pages (from-to)371-380
Number of pages10
JournalInternational Journal of Gynecological Cancer
Volume26
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Ovarian Neoplasms
Meta-Analysis
Carcinoma
Chest Tubes
Diaphragm
Odds Ratio
Subphrenic Abscess
Confidence Intervals
Pneumothorax
Pleural Effusion
Punctures
PubMed
MEDLINE
Software
Databases
Morbidity
Lung
Survival

Keywords

  • Diaphragmatic surgery
  • Morbidity
  • Ovarian cancer
  • Pulmonary complications
  • Survival

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

@article{8a875b46b1dd45848c121645112c63e4,
title = "Surgical Techniques for Diaphragmatic Resection during Cytoreduction in Advanced or Recurrent Ovarian Carcinoma: A Systematic Review and Meta-analysis",
abstract = "Objective Optimal cytoreduction is one the main factors improving survival outcomes in patients affected by ovarian cancer (OC). It is estimated that approximately 40{\%} of OC patients have gross disease located on the diaphragm. However, no mature data evaluating outcomes of surgical techniques for the management of diaphragmatic carcinosis exist. In the present study, we aimed to estimate surgery-related morbidity of different surgical techniques for diaphragmatic cytoreduction in advanced or recurrent OC. Methods PubMed (MEDLINE), Web of Science, and Clincaltrials.gov databases were searched for records estimating outcomes of diaphragmatic peritoneal stripping (DPS) or diaphragmatic full-thickness resection (DFTR) for OC. The meta-analysis was performed using the Cochrane Review software. Results For the final analysis, 5 articles were available, including 272 patients. Diaphragmatic peritoneal stripping and DFTR were performed in 197 patients (72{\%}) and 75 patients (28{\%}), respectively. Pooled analysis suggested that the estimated pleural effusion rate was 43{\%} and 51{\%} after DPS and DFTR, respectively. The need for pleural punctures or chest tube placement was 4{\%} and 9{\%} after DPS and DFTR, respectively. The rate of postoperative pneumothorax (4{\%} vs 9{\%}; odds ratio, 0.31; 95{\%} confidence interval, 0.05-2.08) and subdiaphragmatic abscess (3{\%} vs 3{\%}; odds ratio, 0.45; 95{\%} confidence interval, 0.09-2.31) were similar after the execution of DPS and DFTR. Conclusions Diaphragmatic surgery is a crucial step during cytoreduction for advanced or recurrent OC. Obviously, the choice to perform DPS or DFTR depends on the infiltration of the diaphragmatic muscle or not. Both the procedures are associated with a low pulmonary complication and chest tube placement rates.",
keywords = "Diaphragmatic surgery, Morbidity, Ovarian cancer, Pulmonary complications, Survival",
author = "Giorgio Bogani and Antonino Ditto and Fabio Martinelli and Domenica Lorusso and Valentina Chiappa and Cristina Donfrancesco and {Di Donato}, Violante and Alice Indini and Giovanni Aletti and Francesco Raspagliesi",
year = "2016",
month = "2",
day = "1",
doi = "10.1097/IGC.0000000000000597",
language = "English",
volume = "26",
pages = "371--380",
journal = "International Journal of Gynecological Cancer",
issn = "1048-891X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Surgical Techniques for Diaphragmatic Resection during Cytoreduction in Advanced or Recurrent Ovarian Carcinoma

T2 - A Systematic Review and Meta-analysis

AU - Bogani, Giorgio

AU - Ditto, Antonino

AU - Martinelli, Fabio

AU - Lorusso, Domenica

AU - Chiappa, Valentina

AU - Donfrancesco, Cristina

AU - Di Donato, Violante

AU - Indini, Alice

AU - Aletti, Giovanni

AU - Raspagliesi, Francesco

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objective Optimal cytoreduction is one the main factors improving survival outcomes in patients affected by ovarian cancer (OC). It is estimated that approximately 40% of OC patients have gross disease located on the diaphragm. However, no mature data evaluating outcomes of surgical techniques for the management of diaphragmatic carcinosis exist. In the present study, we aimed to estimate surgery-related morbidity of different surgical techniques for diaphragmatic cytoreduction in advanced or recurrent OC. Methods PubMed (MEDLINE), Web of Science, and Clincaltrials.gov databases were searched for records estimating outcomes of diaphragmatic peritoneal stripping (DPS) or diaphragmatic full-thickness resection (DFTR) for OC. The meta-analysis was performed using the Cochrane Review software. Results For the final analysis, 5 articles were available, including 272 patients. Diaphragmatic peritoneal stripping and DFTR were performed in 197 patients (72%) and 75 patients (28%), respectively. Pooled analysis suggested that the estimated pleural effusion rate was 43% and 51% after DPS and DFTR, respectively. The need for pleural punctures or chest tube placement was 4% and 9% after DPS and DFTR, respectively. The rate of postoperative pneumothorax (4% vs 9%; odds ratio, 0.31; 95% confidence interval, 0.05-2.08) and subdiaphragmatic abscess (3% vs 3%; odds ratio, 0.45; 95% confidence interval, 0.09-2.31) were similar after the execution of DPS and DFTR. Conclusions Diaphragmatic surgery is a crucial step during cytoreduction for advanced or recurrent OC. Obviously, the choice to perform DPS or DFTR depends on the infiltration of the diaphragmatic muscle or not. Both the procedures are associated with a low pulmonary complication and chest tube placement rates.

AB - Objective Optimal cytoreduction is one the main factors improving survival outcomes in patients affected by ovarian cancer (OC). It is estimated that approximately 40% of OC patients have gross disease located on the diaphragm. However, no mature data evaluating outcomes of surgical techniques for the management of diaphragmatic carcinosis exist. In the present study, we aimed to estimate surgery-related morbidity of different surgical techniques for diaphragmatic cytoreduction in advanced or recurrent OC. Methods PubMed (MEDLINE), Web of Science, and Clincaltrials.gov databases were searched for records estimating outcomes of diaphragmatic peritoneal stripping (DPS) or diaphragmatic full-thickness resection (DFTR) for OC. The meta-analysis was performed using the Cochrane Review software. Results For the final analysis, 5 articles were available, including 272 patients. Diaphragmatic peritoneal stripping and DFTR were performed in 197 patients (72%) and 75 patients (28%), respectively. Pooled analysis suggested that the estimated pleural effusion rate was 43% and 51% after DPS and DFTR, respectively. The need for pleural punctures or chest tube placement was 4% and 9% after DPS and DFTR, respectively. The rate of postoperative pneumothorax (4% vs 9%; odds ratio, 0.31; 95% confidence interval, 0.05-2.08) and subdiaphragmatic abscess (3% vs 3%; odds ratio, 0.45; 95% confidence interval, 0.09-2.31) were similar after the execution of DPS and DFTR. Conclusions Diaphragmatic surgery is a crucial step during cytoreduction for advanced or recurrent OC. Obviously, the choice to perform DPS or DFTR depends on the infiltration of the diaphragmatic muscle or not. Both the procedures are associated with a low pulmonary complication and chest tube placement rates.

KW - Diaphragmatic surgery

KW - Morbidity

KW - Ovarian cancer

KW - Pulmonary complications

KW - Survival

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