Surgical therapy for hepatolithiasis: A Western experience

Gaetano Vetrone, Giorgio Ercolani, Gian Luca Grazi, Giovanni Ramacciato, Matteo Ravaioli, Matteo Cescon, Giovanni Varotti, Massimo Del Gaudio, Cristiano Quintini, Antonio Daniele Pinna

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Hepatolithiasis is very common in East Asia but infrequent in Western countries, and few reports have been published in European series. In East Asia, the association between cholangiocarcinoma and hepatolithiasis is well recognized, but, on the contrary, hepatolithiasis is uncommon in Europe and the United States, and the relationship with cholangiocarcinoma is not well established. The goal of this study was to analyze the perioperative and longterm results of surgical therapy for hepatolithiasis. STUDY DESIGN: Record review of 22 patients was done to locate immediate (operative morbidity and mortality) and longterm (stone recurrence and survival) results of patients with hepatolithiasis who underwent surgical treatment. RESULTS: There were 19 (86.4%) hepatic resections and 10 (45.5%) hepaticojejunoanastomoses. Operative mortality was absent and morbidity rate was 27.3%. Right hepatectomy was predictive of postoperative complications at multivariate analysis (p = 0.04). One (4.5%) patient had an unknown associated cholangiocarcinoma at time of surgical intervention. Mean followup was 67.59 ± 65.67 (range 12 to 215) months. None presented recurrent cholangitis during the followup period. CONCLUSIONS: Surgical therapy is a safe and effective management for hepatolithiasis. The possibility of developing cholangiocarcinoma in inveterate hepatolithiasis is real, and hepatic resection removes this risk.

Original languageEnglish
Pages (from-to)306-312
Number of pages7
JournalJournal of the American College of Surgeons
Issue number2
Publication statusPublished - Feb 2006

ASJC Scopus subject areas

  • Surgery


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