Surgical treatment and prognostic variables of hepatocellular carcinoma in 122 cirrhotics

V. Di Carlo, G. Ferrari, R. Castoldi, S. Nadalin, C. Marenghi, B. Molteni, G. Taccagni, M. Castrucci

Research output: Contribution to journalArticlepeer-review


A 10-year experience in surgical treatment of HCC in 122 cirrhotic patients has been reviewed in order to evaluate: perioperative mortality and morbidity, survival rates and prognostic variables by multiple-logistic analysis. Mortality rate declined from 7% in period 1983-88 to 2% in period 1989-92. Operative complications also decreased from 46% to 30%. The 3-year and 5-year overall survival rates were 42.6% and 23.3%. The 3-year and 5-year survival of patients who died only for HCC was 51.1% and 34.2% and the disease-free survival 30.6% and 19.1%. The good results of overall survival were vanished by the high rate of recurrence (19.1%). Multiple logistic regression analysis for the probability of mortality was significant for satellite nodules (RR 2.437), microvascular infiltration (RR 2.432), tumor size (RR 1.147); the model for the probability of recurrence was significant for microvascular infiltration (RR 2.290), satellite nodules (RR 2.280), lesions number (RR 2.216) and tumor size (RR 1.247).

Original languageEnglish
Pages (from-to)222-229
Number of pages8
Issue number3
Publication statusPublished - 1995


  • Cirrhosis
  • Hepatocellular carcinoma
  • Prognostic factors
  • Surgical treatment

ASJC Scopus subject areas

  • Gastroenterology


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