Surgical treatment of advanced colorectal cancer in the elderly.

Antonio Chiappa, Andrew P. Zbar, Emilio Bertani, Roberto Biffi, Fabrizio Luca, Ugo Pace, Giuseppe Viale, Giancarlo Pruneri, Roberto Orecchia, Roberta Lazzari, Francesca Biella, Carmine Grassi, Giulia Zampino, Nicola Fazio, Paolo Della Vigna, Luca Andreoni, Bruno Andreoni

Research output: Contribution to journalArticlepeer-review


The aim of the study was to compare the short and long-term outcomes of older and younger colorectal cancer patients with advanced disease resected with a curative intent. Six hundred and ninety-two patients were analysed. Four hundred and seventy-nine patients were younger than 70 years (Group 1), and 213 were 70 years of age or above (Group 2). The overall perioperative mortality rate in the younger group was 0.8% (n = 7), as against 1.4% (n = 3) in the elderly group (p = NS). The morbidity rates were 35% and 42%, respectively (p = NS). At univariate analysis, the elderly patients had a worse overall survival compared to the younger group, when only patients undergoing postoperative chemo-radiotherapy were considered (54% vs 67% overall survival at 5 years; p = 0.03). Using logistic regression analysis, tumour stage (p <0.0001) and radicality of surgery (p <0.0001) correlated significantly with overall survival rates in the elderly. Colorectal surgery for malignancy can be performed safely in the elderly with acceptable morbidity and mortality rates and long-term survival.

Original languageEnglish
Pages (from-to)589-596
Number of pages8
JournalChirurgia Italiana
Issue number5
Publication statusPublished - Sep 2005

ASJC Scopus subject areas

  • Surgery

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