Surgical treatment of chronic thromboembolic pulmonary hypertension

David P. Jenkins, Michael Madani, Eckhard Mayer, Kim Kerr, Nic Kim, Walter Klepetko, Marco Morsolini, Philippe Dartevelle

Research output: Contribution to journalArticlepeer-review

Abstract

It is likely that chronic thromboembolic pulmonary hypertension (CTEPH) is more prevalent than currently recognised. Imaging studies are fundamental to decision making with respect to operability. All patients with suspected CTEPH should be referred to an experienced surgical centre. Currently, there is no risk scoring stratification system to guide operability assessment and it is predominantly based on surgical experience. The aim of pulmonary endarterectomy (PEA) is the removal of obstructive material to immediately reduce pulmonary vascular resistance. PEA affords the best chance of cure, but is difficult to perfect. Recognition and clearance of distal segmental and subsegmental disease is the main problem. The basic surgical techniques include: median sternotomy incision, cardiopulmonary bypass, arteriotomy incisions within pericardium, and a true endarterectomy with meticulous full distal dissection. Deep hypothermic circulatory arrest is recommended as the best means of reducing blood flow in the pulmonary artery to allow a clear field for dissection. In the recent PEACOG (PEA and COGnition) trial there was no evidence of cognitive impairment post-PEA. Reperfusion pulmonary oedema and residual pulmonary hypertension are unique postoperative complications post-PEA and are associated with increased mortality. However, inhospital mortality is now ,5% in experienced centres.

Original languageEnglish
Pages (from-to)735-742
Number of pages8
JournalEuropean Respiratory Journal
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 1 2013

Keywords

  • Chronic thromboembolic pulmonary hypertension
  • Deep hypothermic circulatory arrest
  • Pulmonary artery
  • Pulmonary endarterectomy
  • Pulmonary vascular resistance
  • Reperfusion lung injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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