Surgical treatment of intrathyroid metastases

Preliminary results of a multicentric study

Filippo Calzolari, Paola Vincenza Sartori, Carlo Talarico, Domenico Parmeggiani, Edoardo Beretta, Luciano Pezzullo, Giorgio Bovo, Pasquale Sperlongano, Massimo Monacelli, Roberta Lucchini, Claudia Misso, Angela Gurrado, Michele D'Ajello, Franco Uggeri, Efisio Puxeddu, Iergiorgio Nasi, Mario Testini, Lodovico Rosato, Alfonso Barbarisi, Nicola Avenia

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: Intrathyroid metastases (ITM) are rare and usually have a dismal prognosis. The aim of this study was to detect which neoplasms metastasize most often to the thyroid gland, their clinical features and treatment options. Materials and Methods: Retrospective analysis of clinical files of 17,122 patients submitted to surgery for thyroid disease between 1995 and 2005. Twenty-five patients (median age 61 years) were affected by ITM. Results: The site of the primary tumor was: kidney (15), lung (4), colon (3), breast (1), melanoma (1), and unknown in 1 patient. Ten patients (40% ) complained of preoperative symptoms, in the others, thyroid involvement was incidentally discovered during the follow-up for the primary cancer. Twenty patients (80%) underwent total thyroidectomy, 3 received thyroid lobectomy and 2 palliative procedures. Morbidity was 16%, mortality was nil. The median follow-up was 24 months. Conclusion: TTM should always be suspected in any patient with a previous history of malignancy. Fine-needle agobiopsy (FNAB) with immunohistochemical stains may help in preoperative workup. A long delay between the primary tumor and the recurrence warrants surgery and total thyroidectomy seems to be the treatment of choice because of the multifocality of metastasis to the thyroid gland.

Original languageEnglish
Pages (from-to)2885-2888
Number of pages4
JournalAnticancer Research
Volume28
Issue number5 B
Publication statusPublished - Sep 2008

Fingerprint

Neoplasm Metastasis
Thyroid Gland
Thyroidectomy
Neoplasms
Therapeutics
Thyroid Diseases
Needles
Melanoma
Colon
Breast
Coloring Agents
Morbidity
Kidney
Recurrence
Lung
Mortality

Keywords

  • Carcinoma
  • Metastases
  • Neoplasm
  • Surgery
  • Thyroid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Calzolari, F., Sartori, P. V., Talarico, C., Parmeggiani, D., Beretta, E., Pezzullo, L., ... Avenia, N. (2008). Surgical treatment of intrathyroid metastases: Preliminary results of a multicentric study. Anticancer Research, 28(5 B), 2885-2888.

Surgical treatment of intrathyroid metastases : Preliminary results of a multicentric study. / Calzolari, Filippo; Sartori, Paola Vincenza; Talarico, Carlo; Parmeggiani, Domenico; Beretta, Edoardo; Pezzullo, Luciano; Bovo, Giorgio; Sperlongano, Pasquale; Monacelli, Massimo; Lucchini, Roberta; Misso, Claudia; Gurrado, Angela; D'Ajello, Michele; Uggeri, Franco; Puxeddu, Efisio; Nasi, Iergiorgio; Testini, Mario; Rosato, Lodovico; Barbarisi, Alfonso; Avenia, Nicola.

In: Anticancer Research, Vol. 28, No. 5 B, 09.2008, p. 2885-2888.

Research output: Contribution to journalArticle

Calzolari, F, Sartori, PV, Talarico, C, Parmeggiani, D, Beretta, E, Pezzullo, L, Bovo, G, Sperlongano, P, Monacelli, M, Lucchini, R, Misso, C, Gurrado, A, D'Ajello, M, Uggeri, F, Puxeddu, E, Nasi, I, Testini, M, Rosato, L, Barbarisi, A & Avenia, N 2008, 'Surgical treatment of intrathyroid metastases: Preliminary results of a multicentric study', Anticancer Research, vol. 28, no. 5 B, pp. 2885-2888.
Calzolari F, Sartori PV, Talarico C, Parmeggiani D, Beretta E, Pezzullo L et al. Surgical treatment of intrathyroid metastases: Preliminary results of a multicentric study. Anticancer Research. 2008 Sep;28(5 B):2885-2888.
Calzolari, Filippo ; Sartori, Paola Vincenza ; Talarico, Carlo ; Parmeggiani, Domenico ; Beretta, Edoardo ; Pezzullo, Luciano ; Bovo, Giorgio ; Sperlongano, Pasquale ; Monacelli, Massimo ; Lucchini, Roberta ; Misso, Claudia ; Gurrado, Angela ; D'Ajello, Michele ; Uggeri, Franco ; Puxeddu, Efisio ; Nasi, Iergiorgio ; Testini, Mario ; Rosato, Lodovico ; Barbarisi, Alfonso ; Avenia, Nicola. / Surgical treatment of intrathyroid metastases : Preliminary results of a multicentric study. In: Anticancer Research. 2008 ; Vol. 28, No. 5 B. pp. 2885-2888.
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AU - Nasi, Iergiorgio

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