Abstract
Background: Intrathyroid metastases (ITM) are rare and usually have a dismal prognosis. The aim of this study was to detect which neoplasms metastasize most often to the thyroid gland, their clinical features and treatment options. Materials and Methods: Retrospective analysis of clinical files of 17,122 patients submitted to surgery for thyroid disease between 1995 and 2005. Twenty-five patients (median age 61 years) were affected by ITM. Results: The site of the primary tumor was: kidney (15), lung (4), colon (3), breast (1), melanoma (1), and unknown in 1 patient. Ten patients (40% ) complained of preoperative symptoms, in the others, thyroid involvement was incidentally discovered during the follow-up for the primary cancer. Twenty patients (80%) underwent total thyroidectomy, 3 received thyroid lobectomy and 2 palliative procedures. Morbidity was 16%, mortality was nil. The median follow-up was 24 months. Conclusion: TTM should always be suspected in any patient with a previous history of malignancy. Fine-needle agobiopsy (FNAB) with immunohistochemical stains may help in preoperative workup. A long delay between the primary tumor and the recurrence warrants surgery and total thyroidectomy seems to be the treatment of choice because of the multifocality of metastasis to the thyroid gland.
| Original language | English |
|---|---|
| Pages (from-to) | 2885-2888 |
| Number of pages | 4 |
| Journal | Anticancer Research |
| Volume | 28 |
| Issue number | 5 B |
| Publication status | Published - Sep 2008 |
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Keywords
- Carcinoma
- Metastases
- Neoplasm
- Surgery
- Thyroid
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Surgical treatment of intrathyroid metastases : Preliminary results of a multicentric study. / Calzolari, Filippo; Sartori, Paola Vincenza; Talarico, Carlo; Parmeggiani, Domenico; Beretta, Edoardo; Pezzullo, Luciano; Bovo, Giorgio; Sperlongano, Pasquale; Monacelli, Massimo; Lucchini, Roberta; Misso, Claudia; Gurrado, Angela; D'Ajello, Michele; Uggeri, Franco; Puxeddu, Efisio; Nasi, Iergiorgio; Testini, Mario; Rosato, Lodovico; Barbarisi, Alfonso; Avenia, Nicola.
In: Anticancer Research, Vol. 28, No. 5 B, 09.2008, p. 2885-2888.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Surgical treatment of intrathyroid metastases
T2 - Preliminary results of a multicentric study
AU - Calzolari, Filippo
AU - Sartori, Paola Vincenza
AU - Talarico, Carlo
AU - Parmeggiani, Domenico
AU - Beretta, Edoardo
AU - Pezzullo, Luciano
AU - Bovo, Giorgio
AU - Sperlongano, Pasquale
AU - Monacelli, Massimo
AU - Lucchini, Roberta
AU - Misso, Claudia
AU - Gurrado, Angela
AU - D'Ajello, Michele
AU - Uggeri, Franco
AU - Puxeddu, Efisio
AU - Nasi, Iergiorgio
AU - Testini, Mario
AU - Rosato, Lodovico
AU - Barbarisi, Alfonso
AU - Avenia, Nicola
PY - 2008/9
Y1 - 2008/9
N2 - Background: Intrathyroid metastases (ITM) are rare and usually have a dismal prognosis. The aim of this study was to detect which neoplasms metastasize most often to the thyroid gland, their clinical features and treatment options. Materials and Methods: Retrospective analysis of clinical files of 17,122 patients submitted to surgery for thyroid disease between 1995 and 2005. Twenty-five patients (median age 61 years) were affected by ITM. Results: The site of the primary tumor was: kidney (15), lung (4), colon (3), breast (1), melanoma (1), and unknown in 1 patient. Ten patients (40% ) complained of preoperative symptoms, in the others, thyroid involvement was incidentally discovered during the follow-up for the primary cancer. Twenty patients (80%) underwent total thyroidectomy, 3 received thyroid lobectomy and 2 palliative procedures. Morbidity was 16%, mortality was nil. The median follow-up was 24 months. Conclusion: TTM should always be suspected in any patient with a previous history of malignancy. Fine-needle agobiopsy (FNAB) with immunohistochemical stains may help in preoperative workup. A long delay between the primary tumor and the recurrence warrants surgery and total thyroidectomy seems to be the treatment of choice because of the multifocality of metastasis to the thyroid gland.
AB - Background: Intrathyroid metastases (ITM) are rare and usually have a dismal prognosis. The aim of this study was to detect which neoplasms metastasize most often to the thyroid gland, their clinical features and treatment options. Materials and Methods: Retrospective analysis of clinical files of 17,122 patients submitted to surgery for thyroid disease between 1995 and 2005. Twenty-five patients (median age 61 years) were affected by ITM. Results: The site of the primary tumor was: kidney (15), lung (4), colon (3), breast (1), melanoma (1), and unknown in 1 patient. Ten patients (40% ) complained of preoperative symptoms, in the others, thyroid involvement was incidentally discovered during the follow-up for the primary cancer. Twenty patients (80%) underwent total thyroidectomy, 3 received thyroid lobectomy and 2 palliative procedures. Morbidity was 16%, mortality was nil. The median follow-up was 24 months. Conclusion: TTM should always be suspected in any patient with a previous history of malignancy. Fine-needle agobiopsy (FNAB) with immunohistochemical stains may help in preoperative workup. A long delay between the primary tumor and the recurrence warrants surgery and total thyroidectomy seems to be the treatment of choice because of the multifocality of metastasis to the thyroid gland.
KW - Carcinoma
KW - Metastases
KW - Neoplasm
KW - Surgery
KW - Thyroid
UR - http://www.scopus.com/inward/record.url?scp=55749087690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55749087690&partnerID=8YFLogxK
M3 - Article
C2 - 19031929
AN - SCOPUS:55749087690
VL - 28
SP - 2885
EP - 2888
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 5 B
ER -