Surgical treatment of lung cancer invading the chest wall: Results and prognostic factors

Pierre Magdeleinat, Marco Alifano, Cedrik Benbrahem, Lorenzo Spaggiari, Calogero Porrello, Philippe Puyo, Philippe Levasseur, Jean François Regnard

Research output: Contribution to journalArticle

Abstract

Background. The study was performed to assess prognostic factors in patients with lung cancer invading the chest wall treated by surgery. Methods. We reviewed retrospectively clinical records of all patients operated on for lung cancer invading chest wall structures between 1984 and 1998. Results. Two hundred one patients were operated on in this 14-year period. One hundred thirty-seven lobectomies, 55 pneumonectomies, and 9 wedge resections were performed. Extrapleural resection (when invasion was limited to the parietal pleura) and chest wall resection (in the case of invasion of deeper structures) were combined with pulmonary resection in 79 (39%) and 122 (61%) cases, respectively. Pathologic TNM stages were T3N0 in 116 (57.5%) cases, T3N1 in 52 (26%), T3N2 in 27 (13.5%), and T4N0-N1 in 6 (3%). A complete resection was achieved in 167 (83%) cases. Fourteen postoperative deaths (7%) occurred. One hundred thirty-nine patients (74%) underwent postoperative radiotherapy. Actuarial 5-year survival was 24% and 13% after complete and incomplete resection, respectively (p <0.05). Actuarial 5-year survival after complete resection was 25% in T3N0 patients, 20% in T3N1, and 21% in T3N2. In completely resected patients, univariate and multivariate analyses identified three independent prognostic factors: nodal involvement; depth of parietal invasion, and age. Radiation therapy did not improve survival if a complete resection was possible. Conclusions. Completeness of resection, nodal involvement, depth of invasion, and age affect survival of patients with lung cancer invading the chest wall. N2 disease should not be considered a contraindication to surgery.

Original languageEnglish
Pages (from-to)1094-1099
Number of pages6
JournalAnnals of Thoracic Surgery
Volume71
Issue number4
DOIs
Publication statusPublished - 2001

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Thoracic Wall
Lung Neoplasms
Survival
Therapeutics
Radiotherapy
Pneumonectomy
Pleura
Multivariate Analysis
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Magdeleinat, P., Alifano, M., Benbrahem, C., Spaggiari, L., Porrello, C., Puyo, P., ... Regnard, J. F. (2001). Surgical treatment of lung cancer invading the chest wall: Results and prognostic factors. Annals of Thoracic Surgery, 71(4), 1094-1099. https://doi.org/10.1016/S0003-4975(00)02666-7

Surgical treatment of lung cancer invading the chest wall : Results and prognostic factors. / Magdeleinat, Pierre; Alifano, Marco; Benbrahem, Cedrik; Spaggiari, Lorenzo; Porrello, Calogero; Puyo, Philippe; Levasseur, Philippe; Regnard, Jean François.

In: Annals of Thoracic Surgery, Vol. 71, No. 4, 2001, p. 1094-1099.

Research output: Contribution to journalArticle

Magdeleinat, P, Alifano, M, Benbrahem, C, Spaggiari, L, Porrello, C, Puyo, P, Levasseur, P & Regnard, JF 2001, 'Surgical treatment of lung cancer invading the chest wall: Results and prognostic factors', Annals of Thoracic Surgery, vol. 71, no. 4, pp. 1094-1099. https://doi.org/10.1016/S0003-4975(00)02666-7
Magdeleinat, Pierre ; Alifano, Marco ; Benbrahem, Cedrik ; Spaggiari, Lorenzo ; Porrello, Calogero ; Puyo, Philippe ; Levasseur, Philippe ; Regnard, Jean François. / Surgical treatment of lung cancer invading the chest wall : Results and prognostic factors. In: Annals of Thoracic Surgery. 2001 ; Vol. 71, No. 4. pp. 1094-1099.
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abstract = "Background. The study was performed to assess prognostic factors in patients with lung cancer invading the chest wall treated by surgery. Methods. We reviewed retrospectively clinical records of all patients operated on for lung cancer invading chest wall structures between 1984 and 1998. Results. Two hundred one patients were operated on in this 14-year period. One hundred thirty-seven lobectomies, 55 pneumonectomies, and 9 wedge resections were performed. Extrapleural resection (when invasion was limited to the parietal pleura) and chest wall resection (in the case of invasion of deeper structures) were combined with pulmonary resection in 79 (39{\%}) and 122 (61{\%}) cases, respectively. Pathologic TNM stages were T3N0 in 116 (57.5{\%}) cases, T3N1 in 52 (26{\%}), T3N2 in 27 (13.5{\%}), and T4N0-N1 in 6 (3{\%}). A complete resection was achieved in 167 (83{\%}) cases. Fourteen postoperative deaths (7{\%}) occurred. One hundred thirty-nine patients (74{\%}) underwent postoperative radiotherapy. Actuarial 5-year survival was 24{\%} and 13{\%} after complete and incomplete resection, respectively (p <0.05). Actuarial 5-year survival after complete resection was 25{\%} in T3N0 patients, 20{\%} in T3N1, and 21{\%} in T3N2. In completely resected patients, univariate and multivariate analyses identified three independent prognostic factors: nodal involvement; depth of parietal invasion, and age. Radiation therapy did not improve survival if a complete resection was possible. Conclusions. Completeness of resection, nodal involvement, depth of invasion, and age affect survival of patients with lung cancer invading the chest wall. N2 disease should not be considered a contraindication to surgery.",
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AU - Magdeleinat, Pierre

AU - Alifano, Marco

AU - Benbrahem, Cedrik

AU - Spaggiari, Lorenzo

AU - Porrello, Calogero

AU - Puyo, Philippe

AU - Levasseur, Philippe

AU - Regnard, Jean François

PY - 2001

Y1 - 2001

N2 - Background. The study was performed to assess prognostic factors in patients with lung cancer invading the chest wall treated by surgery. Methods. We reviewed retrospectively clinical records of all patients operated on for lung cancer invading chest wall structures between 1984 and 1998. Results. Two hundred one patients were operated on in this 14-year period. One hundred thirty-seven lobectomies, 55 pneumonectomies, and 9 wedge resections were performed. Extrapleural resection (when invasion was limited to the parietal pleura) and chest wall resection (in the case of invasion of deeper structures) were combined with pulmonary resection in 79 (39%) and 122 (61%) cases, respectively. Pathologic TNM stages were T3N0 in 116 (57.5%) cases, T3N1 in 52 (26%), T3N2 in 27 (13.5%), and T4N0-N1 in 6 (3%). A complete resection was achieved in 167 (83%) cases. Fourteen postoperative deaths (7%) occurred. One hundred thirty-nine patients (74%) underwent postoperative radiotherapy. Actuarial 5-year survival was 24% and 13% after complete and incomplete resection, respectively (p <0.05). Actuarial 5-year survival after complete resection was 25% in T3N0 patients, 20% in T3N1, and 21% in T3N2. In completely resected patients, univariate and multivariate analyses identified three independent prognostic factors: nodal involvement; depth of parietal invasion, and age. Radiation therapy did not improve survival if a complete resection was possible. Conclusions. Completeness of resection, nodal involvement, depth of invasion, and age affect survival of patients with lung cancer invading the chest wall. N2 disease should not be considered a contraindication to surgery.

AB - Background. The study was performed to assess prognostic factors in patients with lung cancer invading the chest wall treated by surgery. Methods. We reviewed retrospectively clinical records of all patients operated on for lung cancer invading chest wall structures between 1984 and 1998. Results. Two hundred one patients were operated on in this 14-year period. One hundred thirty-seven lobectomies, 55 pneumonectomies, and 9 wedge resections were performed. Extrapleural resection (when invasion was limited to the parietal pleura) and chest wall resection (in the case of invasion of deeper structures) were combined with pulmonary resection in 79 (39%) and 122 (61%) cases, respectively. Pathologic TNM stages were T3N0 in 116 (57.5%) cases, T3N1 in 52 (26%), T3N2 in 27 (13.5%), and T4N0-N1 in 6 (3%). A complete resection was achieved in 167 (83%) cases. Fourteen postoperative deaths (7%) occurred. One hundred thirty-nine patients (74%) underwent postoperative radiotherapy. Actuarial 5-year survival was 24% and 13% after complete and incomplete resection, respectively (p <0.05). Actuarial 5-year survival after complete resection was 25% in T3N0 patients, 20% in T3N1, and 21% in T3N2. In completely resected patients, univariate and multivariate analyses identified three independent prognostic factors: nodal involvement; depth of parietal invasion, and age. Radiation therapy did not improve survival if a complete resection was possible. Conclusions. Completeness of resection, nodal involvement, depth of invasion, and age affect survival of patients with lung cancer invading the chest wall. N2 disease should not be considered a contraindication to surgery.

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