Surgical treatment of lung metastases: The European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group study of 255 patients

Albert N. Van Geel, Ugo Pastorino, Karl W. Jauch, Ian R. Judson, Frits Van Coevorden, José M. Buesa, Ole S. Nielsen, Alain Boudinet, Tomas Tursz, Paul I M Schmitz

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND. Several reports have shown a prolonged survival after surgical treatment of pulmonary metastases from soft tissue sarcomas. However, it is still unclear which prognostic factors predict a favorable outcome. Series are not comparable and the data are conflicting. Therefore, a multi- institutional study was undertaken to analyze prognostic factors in selecting patients for resection of pulmonary metastases from soft tissue sarcomas. METHODS. This report is a retrospective study of the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group. Two hundred fifty-five patients underwent complete resection of lung metastases from soft tissue sarcomas. Cases with chondrosarcoma and small round cell sarcomas like Ewing sarcoma were excluded. RESULTS. The 3 year and 5 year overall postmetastasectomy survival rates were 54% and 38%, respectively. The disease free postmetastasectomy survival rates were 42% and 35%, respectively. Analysis of prognostic factors for a more favorable outcome revealed disease free intervals of 2.5 years or more, following a resection with microscopically free margins, age less than 40 years, and Grade I and II tumors. These prognostic factors have an independent influence on overall survival, using a multivariate Cox regression model. CONCLUSIONS. Surgical excision of lung metastases from soft tissue sarcomas is well accepted and should be considered as a first line of treatment if preoperative evaluation indicates that complete clearance of the metastases is possible. Further investigation is needed before chemotherapy can be recommended as additional therapy.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalCancer
Volume77
Issue number4
DOIs
Publication statusPublished - Feb 15 1996

Keywords

  • lung
  • metastasectomy
  • metastases
  • soft tissue sarcoma
  • thoracotomy/sternotomy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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