Surgical treatment of multiple primary adenocarcinomas of the lung

A. Carretta, P. Ciriaco, G. Melloni, A. Bandiera, L. Libretti, A. Puglisi, M. Giovanardi, P. Zannini

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Introduction: The incidence of lung adenocarcinomas has steadily increased over the last decades. The aim of this study was to assess the results of surgical treatment of multiple primary adenocarcinomas of the lung (MPAL) analyzing the radiological and histological features. Methods: From 1988 to 2005, 26 patients underwent surgical treatment for MPAL at our department, for a total of 52 tumors. Three patients had synchronous and 23 had metachronous tumors. Results: Thirty-seven tumors were classified as solid, two as ground-glass opacities (GGO) and 13 as mixed solid/GGO tumors on the basis of CT scan evaluation. Histology revealed 26 adenocarcinomas, five adenocarcinomas with a bronchioloalveolar (BAC) pattern and 21 BAC. There was no postoperative mortality. Five-year survival of patients with synchronous tumors was 66%. Survival of patients with metachronous tumors was 95% and 70% from the first and second operation. Patients with stage II and IIIa tumors had significantly reduced survival rates (p <0.05). Survival was 60% after lobectomy and 78% after wedge resection. Conclusions: Surgical treatment of MPAL is associated with favorable results. Sublobar resections, when technically feasible, provide adequate oncological management.

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalThoracic and Cardiovascular Surgeon
Volume57
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Neoplasms
Therapeutics
Glass
Survival
Adenocarcinoma
Adenocarcinoma of lung
Histology
Survival Rate
Mortality
Incidence

Keywords

  • Adenocarcinoma
  • Multiple
  • Pulmonary
  • Thoracic surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Carretta, A., Ciriaco, P., Melloni, G., Bandiera, A., Libretti, L., Puglisi, A., ... Zannini, P. (2009). Surgical treatment of multiple primary adenocarcinomas of the lung. Thoracic and Cardiovascular Surgeon, 57(1), 30-34. https://doi.org/10.1055/s-2008-1038989

Surgical treatment of multiple primary adenocarcinomas of the lung. / Carretta, A.; Ciriaco, P.; Melloni, G.; Bandiera, A.; Libretti, L.; Puglisi, A.; Giovanardi, M.; Zannini, P.

In: Thoracic and Cardiovascular Surgeon, Vol. 57, No. 1, 2009, p. 30-34.

Research output: Contribution to journalArticle

Carretta, A, Ciriaco, P, Melloni, G, Bandiera, A, Libretti, L, Puglisi, A, Giovanardi, M & Zannini, P 2009, 'Surgical treatment of multiple primary adenocarcinomas of the lung', Thoracic and Cardiovascular Surgeon, vol. 57, no. 1, pp. 30-34. https://doi.org/10.1055/s-2008-1038989
Carretta A, Ciriaco P, Melloni G, Bandiera A, Libretti L, Puglisi A et al. Surgical treatment of multiple primary adenocarcinomas of the lung. Thoracic and Cardiovascular Surgeon. 2009;57(1):30-34. https://doi.org/10.1055/s-2008-1038989
Carretta, A. ; Ciriaco, P. ; Melloni, G. ; Bandiera, A. ; Libretti, L. ; Puglisi, A. ; Giovanardi, M. ; Zannini, P. / Surgical treatment of multiple primary adenocarcinomas of the lung. In: Thoracic and Cardiovascular Surgeon. 2009 ; Vol. 57, No. 1. pp. 30-34.
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