Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival

Péter Pál Varga, Zsolt Szövérfi, Charles G. Fisher, Stefano Boriani, Ziya L. Gokaslan, Mark B. Dekutoski, Dean Chou, Nasir A. Quraishi, Jeremy J. Reynolds, Alessandro Luzzati, Richard Williams, Michael G. Fehlings, Niccole M. Germscheid, Aron Lazary, Laurence D. Rhines

Research output: Contribution to journalArticlepeer-review


Purpose: Sacral chordomas (SC) are rare, locally invasive, malignant neoplasms. Despite surgical resection and adjuvant therapies, local recurrence (LR) is common and overall survival (OS) is poor. The objective of this study was to identify prognostic factors that have an impact on the local recurrence-free survival (LRFS) and OS of patients with SC. Methods: Utilizing the AOSpine Knowledge Forum Tumor multicenter ambispective database, surgically treated SC cases were identified. Cox regression modeling was used to assess the effect of several clinically relevant variables on OS and LRFS. Results: A total of 167 patients with surgically treated SC were identified. The male/female ratio was 98/69 with a mean age of 57 ± 15 years at the time of surgery. The LR was 35 % (n = 57), death occurred in 30 % of patients (n = 50) during the study period. The median OS was 6 years post-surgery and LRFS was 4 years. In the univariate analysis, previous tumor surgery at the same site (P = 0.002), intralesional resection (P 

Original languageEnglish
Pages (from-to)1092-1101
Number of pages10
JournalEuropean Spine Journal
Issue number5
Publication statusPublished - May 7 2015


  • Chordoma
  • Cox proportional hazards model
  • Local recurrence
  • Primary spinal tumor
  • Prognostic factors
  • Spinal neoplasms
  • Survival analysis

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Medicine(all)


Dive into the research topics of 'Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival'. Together they form a unique fingerprint.

Cite this