Abstract
Purpose: Sacral chordomas (SC) are rare, locally invasive, malignant neoplasms. Despite surgical resection and adjuvant therapies, local recurrence (LR) is common and overall survival (OS) is poor. The objective of this study was to identify prognostic factors that have an impact on the local recurrence-free survival (LRFS) and OS of patients with SC. Methods: Utilizing the AOSpine Knowledge Forum Tumor multicenter ambispective database, surgically treated SC cases were identified. Cox regression modeling was used to assess the effect of several clinically relevant variables on OS and LRFS. Results: A total of 167 patients with surgically treated SC were identified. The male/female ratio was 98/69 with a mean age of 57 ± 15 years at the time of surgery. The LR was 35 % (n = 57), death occurred in 30 % of patients (n = 50) during the study period. The median OS was 6 years post-surgery and LRFS was 4 years. In the univariate analysis, previous tumor surgery at the same site (P = 0.002), intralesional resection (P
| Original language | English |
|---|---|
| Pages (from-to) | 1092-1101 |
| Number of pages | 10 |
| Journal | European Spine Journal |
| Volume | 24 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 7 2015 |
Fingerprint
Keywords
- Chordoma
- Cox proportional hazards model
- Local recurrence
- Primary spinal tumor
- Prognostic factors
- Spinal neoplasms
- Survival analysis
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine
- Medicine(all)
Cite this
Surgical treatment of sacral chordoma : prognostic variables for local recurrence and overall survival. / Varga, Péter Pál; Szövérfi, Zsolt; Fisher, Charles G.; Boriani, Stefano; Gokaslan, Ziya L.; Dekutoski, Mark B.; Chou, Dean; Quraishi, Nasir A.; Reynolds, Jeremy J.; Luzzati, Alessandro; Williams, Richard; Fehlings, Michael G.; Germscheid, Niccole M.; Lazary, Aron; Rhines, Laurence D.
In: European Spine Journal, Vol. 24, No. 5, 07.05.2015, p. 1092-1101.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Surgical treatment of sacral chordoma
T2 - prognostic variables for local recurrence and overall survival
AU - Varga, Péter Pál
AU - Szövérfi, Zsolt
AU - Fisher, Charles G.
AU - Boriani, Stefano
AU - Gokaslan, Ziya L.
AU - Dekutoski, Mark B.
AU - Chou, Dean
AU - Quraishi, Nasir A.
AU - Reynolds, Jeremy J.
AU - Luzzati, Alessandro
AU - Williams, Richard
AU - Fehlings, Michael G.
AU - Germscheid, Niccole M.
AU - Lazary, Aron
AU - Rhines, Laurence D.
PY - 2015/5/7
Y1 - 2015/5/7
N2 - Purpose: Sacral chordomas (SC) are rare, locally invasive, malignant neoplasms. Despite surgical resection and adjuvant therapies, local recurrence (LR) is common and overall survival (OS) is poor. The objective of this study was to identify prognostic factors that have an impact on the local recurrence-free survival (LRFS) and OS of patients with SC. Methods: Utilizing the AOSpine Knowledge Forum Tumor multicenter ambispective database, surgically treated SC cases were identified. Cox regression modeling was used to assess the effect of several clinically relevant variables on OS and LRFS. Results: A total of 167 patients with surgically treated SC were identified. The male/female ratio was 98/69 with a mean age of 57 ± 15 years at the time of surgery. The LR was 35 % (n = 57), death occurred in 30 % of patients (n = 50) during the study period. The median OS was 6 years post-surgery and LRFS was 4 years. In the univariate analysis, previous tumor surgery at the same site (P = 0.002), intralesional resection (P
AB - Purpose: Sacral chordomas (SC) are rare, locally invasive, malignant neoplasms. Despite surgical resection and adjuvant therapies, local recurrence (LR) is common and overall survival (OS) is poor. The objective of this study was to identify prognostic factors that have an impact on the local recurrence-free survival (LRFS) and OS of patients with SC. Methods: Utilizing the AOSpine Knowledge Forum Tumor multicenter ambispective database, surgically treated SC cases were identified. Cox regression modeling was used to assess the effect of several clinically relevant variables on OS and LRFS. Results: A total of 167 patients with surgically treated SC were identified. The male/female ratio was 98/69 with a mean age of 57 ± 15 years at the time of surgery. The LR was 35 % (n = 57), death occurred in 30 % of patients (n = 50) during the study period. The median OS was 6 years post-surgery and LRFS was 4 years. In the univariate analysis, previous tumor surgery at the same site (P = 0.002), intralesional resection (P
KW - Chordoma
KW - Cox proportional hazards model
KW - Local recurrence
KW - Primary spinal tumor
KW - Prognostic factors
KW - Spinal neoplasms
KW - Survival analysis
UR - http://www.scopus.com/inward/record.url?scp=84940001944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940001944&partnerID=8YFLogxK
U2 - 10.1007/s00586-014-3728-6
DO - 10.1007/s00586-014-3728-6
M3 - Article
C2 - 25533857
AN - SCOPUS:84940001944
VL - 24
SP - 1092
EP - 1101
JO - European Spine Journal
JF - European Spine Journal
SN - 0940-6719
IS - 5
ER -