Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival

Péter Pál Varga; Zsolt Szövérfi; Charles G. Fisher; Stefano Boriani; Ziya L. Gokaslan; Mark B. Dekutoski; Dean Chou; Nasir A. Quraishi; Jeremy J. Reynolds; Alessandro Luzzati; Richard Williams; Michael G. Fehlings; Niccole M. Germscheid; Aron Lazary; Laurence D. Rhines

doi:10.1007/s00586-014-3728-6

Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival

Péter Pál Varga, Zsolt Szövérfi, Charles G. Fisher, Stefano Boriani, Ziya L. Gokaslan, Mark B. Dekutoski, Dean Chou, Nasir A. Quraishi, Jeremy J. Reynolds, Alessandro Luzzati, Richard Williams, Michael G. Fehlings, Niccole M. Germscheid, Aron Lazary, Laurence D. Rhines

Research output: Contribution to journal › Article

Abstract

Purpose: Sacral chordomas (SC) are rare, locally invasive, malignant neoplasms. Despite surgical resection and adjuvant therapies, local recurrence (LR) is common and overall survival (OS) is poor. The objective of this study was to identify prognostic factors that have an impact on the local recurrence-free survival (LRFS) and OS of patients with SC. Methods: Utilizing the AOSpine Knowledge Forum Tumor multicenter ambispective database, surgically treated SC cases were identified. Cox regression modeling was used to assess the effect of several clinically relevant variables on OS and LRFS. Results: A total of 167 patients with surgically treated SC were identified. The male/female ratio was 98/69 with a mean age of 57 ± 15 years at the time of surgery. The LR was 35 % (n = 57), death occurred in 30 % of patients (n = 50) during the study period. The median OS was 6 years post-surgery and LRFS was 4 years. In the univariate analysis, previous tumor surgery at the same site (P = 0.002), intralesional resection (P

Original language	English
Pages (from-to)	1092-1101
Number of pages	10
Journal	European Spine Journal
Volume	24
Issue number	5
DOIs	https://doi.org/10.1007/s00586-014-3728-6
Publication status	Published - May 7 2015

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Keywords

Chordoma
Cox proportional hazards model
Local recurrence
Primary spinal tumor
Prognostic factors
Spinal neoplasms
Survival analysis

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine
Medicine(all)

Cite this

Varga, P. P., Szövérfi, Z., Fisher, C. G., Boriani, S., Gokaslan, Z. L., Dekutoski, M. B., Chou, D., Quraishi, N. A., Reynolds, J. J., Luzzati, A., Williams, R., Fehlings, M. G., Germscheid, N. M., Lazary, A., & Rhines, L. D. (2015). Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival. European Spine Journal, 24(5), 1092-1101. https://doi.org/10.1007/s00586-014-3728-6

Surgical treatment of sacral chordoma : prognostic variables for local recurrence and overall survival. / Varga, Péter Pál; Szövérfi, Zsolt; Fisher, Charles G.; Boriani, Stefano; Gokaslan, Ziya L.; Dekutoski, Mark B.; Chou, Dean; Quraishi, Nasir A.; Reynolds, Jeremy J.; Luzzati, Alessandro; Williams, Richard; Fehlings, Michael G.; Germscheid, Niccole M.; Lazary, Aron; Rhines, Laurence D.

In: European Spine Journal, Vol. 24, No. 5, 07.05.2015, p. 1092-1101.

Research output: Contribution to journal › Article

Varga, PP, Szövérfi, Z, Fisher, CG, Boriani, S, Gokaslan, ZL, Dekutoski, MB, Chou, D, Quraishi, NA, Reynolds, JJ, Luzzati, A, Williams, R, Fehlings, MG, Germscheid, NM, Lazary, A & Rhines, LD 2015, 'Surgical treatment of sacral chordoma: prognostic variables for local recurrence and overall survival', European Spine Journal, vol. 24, no. 5, pp. 1092-1101. https://doi.org/10.1007/s00586-014-3728-6

Varga, Péter Pál ; Szövérfi, Zsolt ; Fisher, Charles G. ; Boriani, Stefano ; Gokaslan, Ziya L. ; Dekutoski, Mark B. ; Chou, Dean ; Quraishi, Nasir A. ; Reynolds, Jeremy J. ; Luzzati, Alessandro ; Williams, Richard ; Fehlings, Michael G. ; Germscheid, Niccole M. ; Lazary, Aron ; Rhines, Laurence D. / Surgical treatment of sacral chordoma : prognostic variables for local recurrence and overall survival. In: European Spine Journal. 2015 ; Vol. 24, No. 5. pp. 1092-1101.

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abstract = "Purpose: Sacral chordomas (SC) are rare, locally invasive, malignant neoplasms. Despite surgical resection and adjuvant therapies, local recurrence (LR) is common and overall survival (OS) is poor. The objective of this study was to identify prognostic factors that have an impact on the local recurrence-free survival (LRFS) and OS of patients with SC. Methods: Utilizing the AOSpine Knowledge Forum Tumor multicenter ambispective database, surgically treated SC cases were identified. Cox regression modeling was used to assess the effect of several clinically relevant variables on OS and LRFS. Results: A total of 167 patients with surgically treated SC were identified. The male/female ratio was 98/69 with a mean age of 57 ± 15 years at the time of surgery. The LR was 35 % (n = 57), death occurred in 30 % of patients (n = 50) during the study period. The median OS was 6 years post-surgery and LRFS was 4 years. In the univariate analysis, previous tumor surgery at the same site (P = 0.002), intralesional resection (P ",

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AU - Varga, Péter Pál

AU - Szövérfi, Zsolt

AU - Fisher, Charles G.

AU - Boriani, Stefano

AU - Gokaslan, Ziya L.

AU - Dekutoski, Mark B.

AU - Chou, Dean

AU - Quraishi, Nasir A.

AU - Reynolds, Jeremy J.

AU - Luzzati, Alessandro

AU - Williams, Richard

AU - Fehlings, Michael G.

AU - Germscheid, Niccole M.

AU - Lazary, Aron

AU - Rhines, Laurence D.

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N2 - Purpose: Sacral chordomas (SC) are rare, locally invasive, malignant neoplasms. Despite surgical resection and adjuvant therapies, local recurrence (LR) is common and overall survival (OS) is poor. The objective of this study was to identify prognostic factors that have an impact on the local recurrence-free survival (LRFS) and OS of patients with SC. Methods: Utilizing the AOSpine Knowledge Forum Tumor multicenter ambispective database, surgically treated SC cases were identified. Cox regression modeling was used to assess the effect of several clinically relevant variables on OS and LRFS. Results: A total of 167 patients with surgically treated SC were identified. The male/female ratio was 98/69 with a mean age of 57 ± 15 years at the time of surgery. The LR was 35 % (n = 57), death occurred in 30 % of patients (n = 50) during the study period. The median OS was 6 years post-surgery and LRFS was 4 years. In the univariate analysis, previous tumor surgery at the same site (P = 0.002), intralesional resection (P

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