Abstract
Purpose: Sacral chordomas (SC) are rare, locally invasive, malignant neoplasms. Despite surgical resection and adjuvant therapies, local recurrence (LR) is common and overall survival (OS) is poor. The objective of this study was to identify prognostic factors that have an impact on the local recurrence-free survival (LRFS) and OS of patients with SC. Methods: Utilizing the AOSpine Knowledge Forum Tumor multicenter ambispective database, surgically treated SC cases were identified. Cox regression modeling was used to assess the effect of several clinically relevant variables on OS and LRFS. Results: A total of 167 patients with surgically treated SC were identified. The male/female ratio was 98/69 with a mean age of 57 ± 15 years at the time of surgery. The LR was 35 % (n = 57), death occurred in 30 % of patients (n = 50) during the study period. The median OS was 6 years post-surgery and LRFS was 4 years. In the univariate analysis, previous tumor surgery at the same site (P = 0.002), intralesional resection (P
Original language | English |
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Pages (from-to) | 1092-1101 |
Number of pages | 10 |
Journal | European Spine Journal |
Volume | 24 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 7 2015 |
Keywords
- Chordoma
- Cox proportional hazards model
- Local recurrence
- Primary spinal tumor
- Prognostic factors
- Spinal neoplasms
- Survival analysis
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine
- Medicine(all)