Surgical Treatment of the Septuagenarian Patients Suffering From Brain Metastases: A Large Retrospective Observational Analytic Cohort-Comparison Study

Alessandro Frati, Alessandro Pesce, Mauro Palmieri, Megi Celniku, Antonino Raco, Maurizio Salvati

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The benefits associated to the surgical treatment of brain metastases (BMs) in elderly patients has been extensively debated due to their higher biological fragility, but we still miss a “threshold.” The aim of this study is to evaluate their outcomes by a systematic comparison with a cohort of the youngest patients of our series of BMs. Methods: The surgical, radiologic, and oncologic outcomes of patients suffering from BM have been retrospectively reviewed for the present study. The patients have been subsequently assigned, according to their age in 2 groups: group A (<45 years old) and group B (>70 years old). Patient, surgery, and lesion-related data were recorded to identify the relationships with the following outcome variables: postoperative Karnofsky performance status, complications, and accessibility to adjuvant treatment. Results: The final cohort consisted of 309 patients, 201 men (65.2%) and 108 women (34.8%); average age was 39.1 ± 3.4 years for group A and 74.8 ± 2.9 years for group B. Expected survival was 6.15 ± 2.18 months for group A and 5.01 ± 2.43 months for group B. The statistical analysis disclosed no significant difference between the 2 groups, in term of postoperative Karnofsky performance status and the incidence of complications. Important, the accessibility to adjuvant treatment was not different between the 2 groups. Conclusions: The surgical treatment of BM in the septuagenarian patients is safe and effective. It increases the chances of long-term survival by preserving the functional and neurological status and leaving intact the accessibility to adjuvant treatments, similarly to what happens in the younger patients.

Original languageEnglish
Pages (from-to)e565-e572
JournalWorld Neurosurgery
Volume114
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Cohort Studies
Neoplasm Metastasis
Brain
Karnofsky Performance Status
Therapeutics
Survival
Incidence

Keywords

  • Adjuvant treatments
  • Brain metastases
  • Elderly
  • KPS
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Surgical Treatment of the Septuagenarian Patients Suffering From Brain Metastases : A Large Retrospective Observational Analytic Cohort-Comparison Study. / Frati, Alessandro; Pesce, Alessandro; Palmieri, Mauro; Celniku, Megi; Raco, Antonino; Salvati, Maurizio.

In: World Neurosurgery, Vol. 114, 01.06.2018, p. e565-e572.

Research output: Contribution to journalArticle

Frati, Alessandro ; Pesce, Alessandro ; Palmieri, Mauro ; Celniku, Megi ; Raco, Antonino ; Salvati, Maurizio. / Surgical Treatment of the Septuagenarian Patients Suffering From Brain Metastases : A Large Retrospective Observational Analytic Cohort-Comparison Study. In: World Neurosurgery. 2018 ; Vol. 114. pp. e565-e572.
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