Surgical ventricular restoration improves mechanical intraventricular dyssynchrony in ischemic cardiography

Marisa Di Donato, Anna Toso, Vincent Dor, Michel Sabatier, Giuseppe Barletta, Lorenzo Menicanti, Fabio Fantini

Research output: Contribution to journalArticlepeer-review

Abstract

Background - In ischemic cardiomyopathy, dyssynchrony of left ventricular (LV) mechanical contraction produces adverse hemodynamic consequences. This study tests the capacity of geometric rebuilding by surgical ventricular restoration (SVR) to restore a more synchronous contractile pattern after a mechanical, rather than electrical, intervention. Methods and Results - A prospective study of the global and regional components of dyssynchrony was conducted in 30 patients (58±8 years of age) undergoing SVR at the Cardiothoracic Center of Monaco. The protocol used simultaneous measurements of ventricular volumes and pressure to construct pressure/volume (P/V) and pressure/length (P/L) loops. Angiograms were done before and after SVR to study a 600-ms cycle during atrial pacing at 100 bpm. Mean QRS duration was similar, at 100±17 ms preoperatively and 114±28 ms postoperatively (NS). Preoperative LV contraction was highly asynchronous, because P/V loops showed abnormal isometric phases with a right shifting. Endocardial time motion was either early or delayed at the end-systolic phase so that P/L loops were markedly abnormal in size, shape, and orientation. Postoperatively, SVR resulted in leftward shifting of P/V loops and increased area; endocardial time motion and P/L loops almost normalized to allow a better contribution of single regions to global ejection. The hemodynamic consequences of SVR were improved ejection fraction (30±13% to 45±12%; P=0.001); reduced end-diastolic and end-systolic volume index (202±76 to 122±48 and 144±69 to 69±40 mL/m2; P=0.001); more rapid peak filling rate (1.75±0.7 to 2.32±0.7 EDV/s; P=0.0001); peak ejection rate (1.7±0.7 to 2.6±0.9 Sv/s; P=0.0002), and mechanical efficiency (0.56±0.15 to 0.65±0.18; P=0.04). Conclusions - SVR produces a mechanical intraventricular resynchronization that improves LV performance.

Original languageEnglish
Pages (from-to)2536-2543
Number of pages8
JournalCirculation
Volume109
Issue number21
DOIs
Publication statusPublished - Jun 1 2004

Keywords

  • Remodeling
  • Surgery
  • Ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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