Surgically-induced bile duct injury is followed by early hepatic oxidative stress. A preliminary experimental study in rats

Germana Lissidini, Giuseppe Piccinni, Piero Portincasa, Ignazio Grattagliano, Angela Gurrado, Mario Testini

Research output: Contribution to journalArticle

Abstract

Background/Aims: To study in the rat whether oxidative stress appears early in a model of short-term cholestasis induced by bile duct ligation. Methodology: Adult male rats underwent proximal bile duct ligation; controls underwent a sham operation. Animals were sacrificed at days 0, 1, 3, 7 and 10. Livers were removed for histological studies and biochemical analysis. Results: GSH and PSH levels declined earlier in mitochondria than cytosol. Data were analyzed for statistical significance by ANOVA analysis. Conclusions: This study represents an experimental model which helps in the interpretation of the damage induced by bile duct injury in humans emphasizing an early detection of bile duct injury after surgery to ensure appropriate treatment and optimal patient outcome.

Original languageEnglish
Pages (from-to)602-605
Number of pages4
JournalHepato-Gastroenterology
Volume56
Issue number91-92
Publication statusPublished - May 2009

    Fingerprint

Keywords

  • Bile duct injury
  • Cholestasis
  • Hepatobiliary surgery

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Lissidini, G., Piccinni, G., Portincasa, P., Grattagliano, I., Gurrado, A., & Testini, M. (2009). Surgically-induced bile duct injury is followed by early hepatic oxidative stress. A preliminary experimental study in rats. Hepato-Gastroenterology, 56(91-92), 602-605.