TY - JOUR
T1 - Surgically-induced bile duct injury is followed by early hepatic oxidative stress. A preliminary experimental study in rats
AU - Lissidini, Germana
AU - Piccinni, Giuseppe
AU - Portincasa, Piero
AU - Grattagliano, Ignazio
AU - Gurrado, Angela
AU - Testini, Mario
PY - 2009/5
Y1 - 2009/5
N2 - Background/Aims: To study in the rat whether oxidative stress appears early in a model of short-term cholestasis induced by bile duct ligation. Methodology: Adult male rats underwent proximal bile duct ligation; controls underwent a sham operation. Animals were sacrificed at days 0, 1, 3, 7 and 10. Livers were removed for histological studies and biochemical analysis. Results: GSH and PSH levels declined earlier in mitochondria than cytosol. Data were analyzed for statistical significance by ANOVA analysis. Conclusions: This study represents an experimental model which helps in the interpretation of the damage induced by bile duct injury in humans emphasizing an early detection of bile duct injury after surgery to ensure appropriate treatment and optimal patient outcome.
AB - Background/Aims: To study in the rat whether oxidative stress appears early in a model of short-term cholestasis induced by bile duct ligation. Methodology: Adult male rats underwent proximal bile duct ligation; controls underwent a sham operation. Animals were sacrificed at days 0, 1, 3, 7 and 10. Livers were removed for histological studies and biochemical analysis. Results: GSH and PSH levels declined earlier in mitochondria than cytosol. Data were analyzed for statistical significance by ANOVA analysis. Conclusions: This study represents an experimental model which helps in the interpretation of the damage induced by bile duct injury in humans emphasizing an early detection of bile duct injury after surgery to ensure appropriate treatment and optimal patient outcome.
KW - Bile duct injury
KW - Cholestasis
KW - Hepatobiliary surgery
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M3 - Article
C2 - 19621663
AN - SCOPUS:67651236487
VL - 56
SP - 602
EP - 605
JO - Acta hepato-splenologica
JF - Acta hepato-splenologica
SN - 0172-6390
IS - 91-92
ER -