Surgifoam and mitoxantrone in the glioblastoma multiforme postresection cavity: The first step of locoregional chemotherapy through an ad hoc-placed catheter: Technical note

Paolo Ferroli, Morgan Broggi, Angelo Franzini, Elio Maccagnano, Massimo Lamperti, Amerigo Boiardi, Giovanni Broggi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To investigate the safety and feasibility of a novel form of treatment offered by the direct intraoperative application of a Surgifoam-mitoxantrone mix into a glioblastoma multiforme postresection cavity. A technique for the placement of an intracavity catheter connected with a subcutaneous reservoir for further locoregional mitoxantrone administration is also described. METHODS: Between January and December 2004, 22 consecutive recurrent glioblastoma multiforme patients (14 men, 8 women; age, 56-72 yr; average, 64 yr; median, 65 yr) were enrolled in this study. All patients underwent image-assisted gross total resection of the pathological tissue. A Surgifoam-mitoxantrone mix (1 g Surgifoam powder, 3 ml physiological solution, and 12 mg mitoxantrone in 6 ml) was used to fill the surgical cavity. A ventricular catheter, connected to a Rickham subcutaneous reservoir, was then positioned in the surgical cavity for future mitoxantrone administration. RESULTS: Toxic effects caused by mitoxantrone administration were not observed in any patients during the first postoperative month. On postoperative Days 1, 7, and 30, computed tomographic scans excluded surgical complications. In three patients, residual tumor was disclosed. CONCLUSION: A mix of Surgifoam and mitoxantrone could be safely applied intraoperatively into the post-glioblastoma multiforme resection cavity without any observable side effects. This technique may benefit both the surgeon and the patient by taking advantage of the drug's hemostatic and cytostatic properties.

Original languageEnglish
JournalNeurosurgery
Volume59
Issue number2
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Glioblastoma
  • Image-guided surgery
  • Locoregional chemotherapy
  • Mitoxantrone
  • Surgifoam

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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