Surrogate Markers in Multiple Sclerosis: The Role of Magnetic Resonance Imaging

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Due to its sensitivity to multiple sclerosis (MS) abnormalities, magnetic resonance imaging (MRI) has become an established tool to diagnose MS and to monitor its evolution. MRI has been included in the diagnostic work-up of patients with clinically isolated syndromes suggestive of MS. In patients with definite MS, the ability of conventional MRI techniques in explaining patients' clinical status and progression of disability is still suboptimal. Several advanced MRI-based technologies have been applied to estimate overall MS burden in the different phases of the disease. Combined with functional imaging techniques, this is improving our understanding of the mechanisms associated to MS evolution. In the near future, the use of ultrahigh field systems is likely to provide additional insight into disease pathophysiology. However, the utility of advanced MRI techniques in clinical trial monitoring and in assessing individual patients' response to treatment still needs to be assessed.

Original languageEnglish
Title of host publicationTranslational Neuroimmunology in Multiple Sclerosis: From Disease Mechanisms to Clinical Applications
PublisherElsevier Inc.
Pages163-187
Number of pages25
ISBN (Electronic)9780128020074
ISBN (Print)9780128019146
DOIs
Publication statusPublished - Aug 3 2016

Keywords

  • Diagnosis
  • Differential diagnosis
  • Diffusion tensor MRI
  • Double-inversion recovery
  • Functional MRI
  • Inflammation
  • Magnetic resonance imaging
  • Magnetization transfer MRI
  • Monitoring
  • Multiple sclerosis
  • Neurodegeneration
  • Pathophysiology
  • Quantitative MRI techniques
  • Spinal cord
  • Treatment outcomes
  • Ultrahigh field MRI

ASJC Scopus subject areas

  • Neuroscience(all)

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