Surveillance of toxoplasma gondii infection in recipients of thoracic solid organ transplants

Eleonora Sarchi, Francesca Genco, Angela Di Matteo, Barbara Castiglioni, Lorenzo Minoli, Valeria Meroni

Research output: Contribution to journalArticle

Abstract

We evaluated the frequency of seroconversion for toxoplasmosis in seronegative recipients of thoracic solid organ transplants with seronegative or seropositive donors and the efficacy of chemoprophylaxis with pyrimethamine+sulfametopirazine. One hundred and sixty one patients seronegative for toxoplasmosis were followed-up at different intervals. Six patients out of 79 R-/D- and twelve out of 82 R-/D+ seroconverted after chemoprophylaxis interruption. There was no difference between matched and mismatched recipients as to the frequency of seroconversion which therefore could not be related to donor seropositivity. Seroconversions were almost asymptomatic. All positive recipients should be tested if symptoms of infection are present.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalNew Microbiologica
Volume30
Issue number3
Publication statusPublished - Jul 2007

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Keywords

  • Prophylaxis
  • Thoracic solid organ transplantation
  • Toxoplasmosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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