Abstract
OBJECTIVES To test the effect of histological subtype (NBSCC vs UC) on cancer-specific mortality (CSM), after adjusting for other-cause mortality (OCM). In Western countries, non-bilharzial squamous cell carcinoma (NBSCC) is the second most common histological subtype in bladder cancer (BCa) after urothelial carcinoma (UC). PATIENTS AND METHODS We identified 12 311 patients who were treated with radical cystectomy (RC) between 1988 and 2006, within 17 Surveillance, Epidemiology and End Results (SEER) registries. Univariable and multivariable competing-risks analyses tested the relationship between histological subtype and CSM, after accounting for OCM. Covariates consisted of age, sex, year of surgery, race, pathological T and N stages, as well as tumour grade. RESULTS Histological subtype was NBSCC in 614 (5%) patients vs UC in 11 697 (95%) patients. At RC, the rate of non-organ confined (NOC) BCa was higher in NBSCC patients than in their UC counterparts (71.7% vs 52.2%; P <0.001). After adjustment for OCM, The 5-year cumulative CSM rates were 25.0% vs 19.8% (P= 0.2) for patients with NBSCC vs UC organ confined (OC) BCa, respectively. The same rates were 46.3% vs 49.3% in patients with NOC BCa (P= 0.1). In multivariable competing-risks analyses, histological subtype (NBSCC vs UC) failed to achieve independent predictor status of CSM in patients with OC (hazard ratio, 1.2; P= 0.06) or NOC BCa (hazard ratio, 1.1; P= 0.1). CONCLUSIONS At RC, the rate of NOC BCa is higher in NBSCC patients than in their UC counterparts. Despite a more advanced stage at surgery, NBSCC histological subtype is not associated with a less favourable CSM than UC histological subtype, after accounting for OCM and the extent of the disease (OC vs NOC).
| Original language | English |
|---|---|
| Pages (from-to) | 564-569 |
| Number of pages | 6 |
| Journal | BJU International |
| Volume | 109 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Feb 2012 |
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Keywords
- carcinoma squamous cell/mortality
- carcinoma squamous cell/pathology
- carcinoma transitional cell/pathology
- cause of death
- neoplasm staging
- survival rate
- transitional cell/mortality carcinoma
- urinary bladder neoplasms/mortality
- urinary bladder neoplasms/pathology
ASJC Scopus subject areas
- Urology
Cite this
Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma : A competing-risks analysis. / Abdollah, Firas; Sun, Maxine; Jeldres, Claudio; Schmitges, Jan; Thuret, Rodolphe; Djahangirian, Orchidee; Tian, Zhe; Shariat, Shahrokh F.; Perrotte, Paul; Montorsi, Francesco; Karakiewicz, Pierre I.
In: BJU International, Vol. 109, No. 4, 02.2012, p. 564-569.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma
T2 - A competing-risks analysis
AU - Abdollah, Firas
AU - Sun, Maxine
AU - Jeldres, Claudio
AU - Schmitges, Jan
AU - Thuret, Rodolphe
AU - Djahangirian, Orchidee
AU - Tian, Zhe
AU - Shariat, Shahrokh F.
AU - Perrotte, Paul
AU - Montorsi, Francesco
AU - Karakiewicz, Pierre I.
PY - 2012/2
Y1 - 2012/2
N2 - OBJECTIVES To test the effect of histological subtype (NBSCC vs UC) on cancer-specific mortality (CSM), after adjusting for other-cause mortality (OCM). In Western countries, non-bilharzial squamous cell carcinoma (NBSCC) is the second most common histological subtype in bladder cancer (BCa) after urothelial carcinoma (UC). PATIENTS AND METHODS We identified 12 311 patients who were treated with radical cystectomy (RC) between 1988 and 2006, within 17 Surveillance, Epidemiology and End Results (SEER) registries. Univariable and multivariable competing-risks analyses tested the relationship between histological subtype and CSM, after accounting for OCM. Covariates consisted of age, sex, year of surgery, race, pathological T and N stages, as well as tumour grade. RESULTS Histological subtype was NBSCC in 614 (5%) patients vs UC in 11 697 (95%) patients. At RC, the rate of non-organ confined (NOC) BCa was higher in NBSCC patients than in their UC counterparts (71.7% vs 52.2%; P <0.001). After adjustment for OCM, The 5-year cumulative CSM rates were 25.0% vs 19.8% (P= 0.2) for patients with NBSCC vs UC organ confined (OC) BCa, respectively. The same rates were 46.3% vs 49.3% in patients with NOC BCa (P= 0.1). In multivariable competing-risks analyses, histological subtype (NBSCC vs UC) failed to achieve independent predictor status of CSM in patients with OC (hazard ratio, 1.2; P= 0.06) or NOC BCa (hazard ratio, 1.1; P= 0.1). CONCLUSIONS At RC, the rate of NOC BCa is higher in NBSCC patients than in their UC counterparts. Despite a more advanced stage at surgery, NBSCC histological subtype is not associated with a less favourable CSM than UC histological subtype, after accounting for OCM and the extent of the disease (OC vs NOC).
AB - OBJECTIVES To test the effect of histological subtype (NBSCC vs UC) on cancer-specific mortality (CSM), after adjusting for other-cause mortality (OCM). In Western countries, non-bilharzial squamous cell carcinoma (NBSCC) is the second most common histological subtype in bladder cancer (BCa) after urothelial carcinoma (UC). PATIENTS AND METHODS We identified 12 311 patients who were treated with radical cystectomy (RC) between 1988 and 2006, within 17 Surveillance, Epidemiology and End Results (SEER) registries. Univariable and multivariable competing-risks analyses tested the relationship between histological subtype and CSM, after accounting for OCM. Covariates consisted of age, sex, year of surgery, race, pathological T and N stages, as well as tumour grade. RESULTS Histological subtype was NBSCC in 614 (5%) patients vs UC in 11 697 (95%) patients. At RC, the rate of non-organ confined (NOC) BCa was higher in NBSCC patients than in their UC counterparts (71.7% vs 52.2%; P <0.001). After adjustment for OCM, The 5-year cumulative CSM rates were 25.0% vs 19.8% (P= 0.2) for patients with NBSCC vs UC organ confined (OC) BCa, respectively. The same rates were 46.3% vs 49.3% in patients with NOC BCa (P= 0.1). In multivariable competing-risks analyses, histological subtype (NBSCC vs UC) failed to achieve independent predictor status of CSM in patients with OC (hazard ratio, 1.2; P= 0.06) or NOC BCa (hazard ratio, 1.1; P= 0.1). CONCLUSIONS At RC, the rate of NOC BCa is higher in NBSCC patients than in their UC counterparts. Despite a more advanced stage at surgery, NBSCC histological subtype is not associated with a less favourable CSM than UC histological subtype, after accounting for OCM and the extent of the disease (OC vs NOC).
KW - carcinoma squamous cell/mortality
KW - carcinoma squamous cell/pathology
KW - carcinoma transitional cell/pathology
KW - cause of death
KW - neoplasm staging
KW - survival rate
KW - transitional cell/mortality carcinoma
KW - urinary bladder neoplasms/mortality
KW - urinary bladder neoplasms/pathology
UR - http://www.scopus.com/inward/record.url?scp=84857033061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857033061&partnerID=8YFLogxK
U2 - 10.1111/j.1464-410X.2011.10357.x
DO - 10.1111/j.1464-410X.2011.10357.x
M3 - Article
C2 - 21810161
AN - SCOPUS:84857033061
VL - 109
SP - 564
EP - 569
JO - BJU International
JF - BJU International
SN - 1464-4096
IS - 4
ER -