Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma: A competing-risks analysis

Firas Abdollah, Maxine Sun, Claudio Jeldres, Jan Schmitges, Rodolphe Thuret, Orchidee Djahangirian, Zhe Tian, Shahrokh F. Shariat, Paul Perrotte, Francesco Montorsi, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES To test the effect of histological subtype (NBSCC vs UC) on cancer-specific mortality (CSM), after adjusting for other-cause mortality (OCM). In Western countries, non-bilharzial squamous cell carcinoma (NBSCC) is the second most common histological subtype in bladder cancer (BCa) after urothelial carcinoma (UC). PATIENTS AND METHODS We identified 12 311 patients who were treated with radical cystectomy (RC) between 1988 and 2006, within 17 Surveillance, Epidemiology and End Results (SEER) registries. Univariable and multivariable competing-risks analyses tested the relationship between histological subtype and CSM, after accounting for OCM. Covariates consisted of age, sex, year of surgery, race, pathological T and N stages, as well as tumour grade. RESULTS Histological subtype was NBSCC in 614 (5%) patients vs UC in 11 697 (95%) patients. At RC, the rate of non-organ confined (NOC) BCa was higher in NBSCC patients than in their UC counterparts (71.7% vs 52.2%; P <0.001). After adjustment for OCM, The 5-year cumulative CSM rates were 25.0% vs 19.8% (P= 0.2) for patients with NBSCC vs UC organ confined (OC) BCa, respectively. The same rates were 46.3% vs 49.3% in patients with NOC BCa (P= 0.1). In multivariable competing-risks analyses, histological subtype (NBSCC vs UC) failed to achieve independent predictor status of CSM in patients with OC (hazard ratio, 1.2; P= 0.06) or NOC BCa (hazard ratio, 1.1; P= 0.1). CONCLUSIONS At RC, the rate of NOC BCa is higher in NBSCC patients than in their UC counterparts. Despite a more advanced stage at surgery, NBSCC histological subtype is not associated with a less favourable CSM than UC histological subtype, after accounting for OCM and the extent of the disease (OC vs NOC).

Original languageEnglish
Pages (from-to)564-569
Number of pages6
JournalBJU International
Volume109
Issue number4
DOIs
Publication statusPublished - Feb 2012

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Cystectomy
Squamous Cell Carcinoma
Carcinoma
Urinary Bladder Neoplasms
Survival
Mortality
Neoplasms
Registries
Epidemiology

Keywords

  • carcinoma squamous cell/mortality
  • carcinoma squamous cell/pathology
  • carcinoma transitional cell/pathology
  • cause of death
  • neoplasm staging
  • survival rate
  • transitional cell/mortality carcinoma
  • urinary bladder neoplasms/mortality
  • urinary bladder neoplasms/pathology

ASJC Scopus subject areas

  • Urology

Cite this

Abdollah, F., Sun, M., Jeldres, C., Schmitges, J., Thuret, R., Djahangirian, O., ... Karakiewicz, P. I. (2012). Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma: A competing-risks analysis. BJU International, 109(4), 564-569. https://doi.org/10.1111/j.1464-410X.2011.10357.x

Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma : A competing-risks analysis. / Abdollah, Firas; Sun, Maxine; Jeldres, Claudio; Schmitges, Jan; Thuret, Rodolphe; Djahangirian, Orchidee; Tian, Zhe; Shariat, Shahrokh F.; Perrotte, Paul; Montorsi, Francesco; Karakiewicz, Pierre I.

In: BJU International, Vol. 109, No. 4, 02.2012, p. 564-569.

Research output: Contribution to journalArticle

Abdollah, F, Sun, M, Jeldres, C, Schmitges, J, Thuret, R, Djahangirian, O, Tian, Z, Shariat, SF, Perrotte, P, Montorsi, F & Karakiewicz, PI 2012, 'Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma: A competing-risks analysis', BJU International, vol. 109, no. 4, pp. 564-569. https://doi.org/10.1111/j.1464-410X.2011.10357.x
Abdollah, Firas ; Sun, Maxine ; Jeldres, Claudio ; Schmitges, Jan ; Thuret, Rodolphe ; Djahangirian, Orchidee ; Tian, Zhe ; Shariat, Shahrokh F. ; Perrotte, Paul ; Montorsi, Francesco ; Karakiewicz, Pierre I. / Survival after radical cystectomy of non-bilharzial squamous cell carcinoma vs urothelial carcinoma : A competing-risks analysis. In: BJU International. 2012 ; Vol. 109, No. 4. pp. 564-569.
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abstract = "OBJECTIVES To test the effect of histological subtype (NBSCC vs UC) on cancer-specific mortality (CSM), after adjusting for other-cause mortality (OCM). In Western countries, non-bilharzial squamous cell carcinoma (NBSCC) is the second most common histological subtype in bladder cancer (BCa) after urothelial carcinoma (UC). PATIENTS AND METHODS We identified 12 311 patients who were treated with radical cystectomy (RC) between 1988 and 2006, within 17 Surveillance, Epidemiology and End Results (SEER) registries. Univariable and multivariable competing-risks analyses tested the relationship between histological subtype and CSM, after accounting for OCM. Covariates consisted of age, sex, year of surgery, race, pathological T and N stages, as well as tumour grade. RESULTS Histological subtype was NBSCC in 614 (5{\%}) patients vs UC in 11 697 (95{\%}) patients. At RC, the rate of non-organ confined (NOC) BCa was higher in NBSCC patients than in their UC counterparts (71.7{\%} vs 52.2{\%}; P <0.001). After adjustment for OCM, The 5-year cumulative CSM rates were 25.0{\%} vs 19.8{\%} (P= 0.2) for patients with NBSCC vs UC organ confined (OC) BCa, respectively. The same rates were 46.3{\%} vs 49.3{\%} in patients with NOC BCa (P= 0.1). In multivariable competing-risks analyses, histological subtype (NBSCC vs UC) failed to achieve independent predictor status of CSM in patients with OC (hazard ratio, 1.2; P= 0.06) or NOC BCa (hazard ratio, 1.1; P= 0.1). CONCLUSIONS At RC, the rate of NOC BCa is higher in NBSCC patients than in their UC counterparts. Despite a more advanced stage at surgery, NBSCC histological subtype is not associated with a less favourable CSM than UC histological subtype, after accounting for OCM and the extent of the disease (OC vs NOC).",
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T2 - A competing-risks analysis

AU - Abdollah, Firas

AU - Sun, Maxine

AU - Jeldres, Claudio

AU - Schmitges, Jan

AU - Thuret, Rodolphe

AU - Djahangirian, Orchidee

AU - Tian, Zhe

AU - Shariat, Shahrokh F.

AU - Perrotte, Paul

AU - Montorsi, Francesco

AU - Karakiewicz, Pierre I.

PY - 2012/2

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N2 - OBJECTIVES To test the effect of histological subtype (NBSCC vs UC) on cancer-specific mortality (CSM), after adjusting for other-cause mortality (OCM). In Western countries, non-bilharzial squamous cell carcinoma (NBSCC) is the second most common histological subtype in bladder cancer (BCa) after urothelial carcinoma (UC). PATIENTS AND METHODS We identified 12 311 patients who were treated with radical cystectomy (RC) between 1988 and 2006, within 17 Surveillance, Epidemiology and End Results (SEER) registries. Univariable and multivariable competing-risks analyses tested the relationship between histological subtype and CSM, after accounting for OCM. Covariates consisted of age, sex, year of surgery, race, pathological T and N stages, as well as tumour grade. RESULTS Histological subtype was NBSCC in 614 (5%) patients vs UC in 11 697 (95%) patients. At RC, the rate of non-organ confined (NOC) BCa was higher in NBSCC patients than in their UC counterparts (71.7% vs 52.2%; P <0.001). After adjustment for OCM, The 5-year cumulative CSM rates were 25.0% vs 19.8% (P= 0.2) for patients with NBSCC vs UC organ confined (OC) BCa, respectively. The same rates were 46.3% vs 49.3% in patients with NOC BCa (P= 0.1). In multivariable competing-risks analyses, histological subtype (NBSCC vs UC) failed to achieve independent predictor status of CSM in patients with OC (hazard ratio, 1.2; P= 0.06) or NOC BCa (hazard ratio, 1.1; P= 0.1). CONCLUSIONS At RC, the rate of NOC BCa is higher in NBSCC patients than in their UC counterparts. Despite a more advanced stage at surgery, NBSCC histological subtype is not associated with a less favourable CSM than UC histological subtype, after accounting for OCM and the extent of the disease (OC vs NOC).

AB - OBJECTIVES To test the effect of histological subtype (NBSCC vs UC) on cancer-specific mortality (CSM), after adjusting for other-cause mortality (OCM). In Western countries, non-bilharzial squamous cell carcinoma (NBSCC) is the second most common histological subtype in bladder cancer (BCa) after urothelial carcinoma (UC). PATIENTS AND METHODS We identified 12 311 patients who were treated with radical cystectomy (RC) between 1988 and 2006, within 17 Surveillance, Epidemiology and End Results (SEER) registries. Univariable and multivariable competing-risks analyses tested the relationship between histological subtype and CSM, after accounting for OCM. Covariates consisted of age, sex, year of surgery, race, pathological T and N stages, as well as tumour grade. RESULTS Histological subtype was NBSCC in 614 (5%) patients vs UC in 11 697 (95%) patients. At RC, the rate of non-organ confined (NOC) BCa was higher in NBSCC patients than in their UC counterparts (71.7% vs 52.2%; P <0.001). After adjustment for OCM, The 5-year cumulative CSM rates were 25.0% vs 19.8% (P= 0.2) for patients with NBSCC vs UC organ confined (OC) BCa, respectively. The same rates were 46.3% vs 49.3% in patients with NOC BCa (P= 0.1). In multivariable competing-risks analyses, histological subtype (NBSCC vs UC) failed to achieve independent predictor status of CSM in patients with OC (hazard ratio, 1.2; P= 0.06) or NOC BCa (hazard ratio, 1.1; P= 0.1). CONCLUSIONS At RC, the rate of NOC BCa is higher in NBSCC patients than in their UC counterparts. Despite a more advanced stage at surgery, NBSCC histological subtype is not associated with a less favourable CSM than UC histological subtype, after accounting for OCM and the extent of the disease (OC vs NOC).

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KW - carcinoma squamous cell/pathology

KW - carcinoma transitional cell/pathology

KW - cause of death

KW - neoplasm staging

KW - survival rate

KW - transitional cell/mortality carcinoma

KW - urinary bladder neoplasms/mortality

KW - urinary bladder neoplasms/pathology

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