Survival after T cell depleted haploidentical stem cell transplantation is improved using the mother as donor

Martin Stern, Loredana Ruggeri, Antonella Mancusi, Maria Ester Bernardo, Claudia De Angelis, Christoph Bucher, Franco Locatelli, Franco Aversa, Andrea Velardi

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

We hypothesized that transplacental leukocyte trafficking during pregnancy, which induces long-term, stable, reciprocal microchimerism in mother and child, might influence outcome of patients with acute leukemia given parental donor haploidentical hematopoietic stem cell transplantation (HSCT). We analyzed the outcome of 118 patients who received transplants for acute leukemia in 2 centers. Patients received highly T celldepleted haploidentical grafts after myeloablative conditioning. Five-year event-free survival was better in patients who received transplants from the mother than from the father (50.6% ± 7.6% vs 11.1% ± 4.2%; P<.001). Better survival was the result of both reduced incidence of relapse and transplantation-related mortality. The protective effect was seen in both female and male recipients, in both lymphoid and myeloid diseases; it was more evident in patients receiving transplants in remission than in chemotherapy-resistant relapse. Incidences of rejection and acute graft-versus-host disease were not significantly influenced. Multivariate analysis confirmed donor sex in parental donor transplantation as an independent prognostic factor for survival (hazard ratio, father vs mother=2.36; P=.003). In contrast, in a control cohort of patients who received transplants from haploidentical siblings, donor sex had no influence on outcome. Although obtained in a retrospective analysis, these data suggest that the mother of the patient should be preferred as donor for haploidentical HSCT.

Original languageEnglish
Pages (from-to)2990-2995
Number of pages6
JournalBlood
Volume112
Issue number7
DOIs
Publication statusPublished - Oct 1 2008

Fingerprint

Transplants
T-cells
Stem Cell Transplantation
Stem cells
Mothers
Tissue Donors
T-Lymphocytes
Survival
Grafts
Hematopoietic Stem Cell Transplantation
Chemotherapy
Fathers
Leukemia
Transplantation
Hazards
Recurrence
Chimerism
Incidence
Graft vs Host Disease
Disease-Free Survival

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Stern, M., Ruggeri, L., Mancusi, A., Bernardo, M. E., De Angelis, C., Bucher, C., ... Velardi, A. (2008). Survival after T cell depleted haploidentical stem cell transplantation is improved using the mother as donor. Blood, 112(7), 2990-2995. https://doi.org/10.1182/blood-2008-01-135285

Survival after T cell depleted haploidentical stem cell transplantation is improved using the mother as donor. / Stern, Martin; Ruggeri, Loredana; Mancusi, Antonella; Bernardo, Maria Ester; De Angelis, Claudia; Bucher, Christoph; Locatelli, Franco; Aversa, Franco; Velardi, Andrea.

In: Blood, Vol. 112, No. 7, 01.10.2008, p. 2990-2995.

Research output: Contribution to journalArticle

Stern, M, Ruggeri, L, Mancusi, A, Bernardo, ME, De Angelis, C, Bucher, C, Locatelli, F, Aversa, F & Velardi, A 2008, 'Survival after T cell depleted haploidentical stem cell transplantation is improved using the mother as donor', Blood, vol. 112, no. 7, pp. 2990-2995. https://doi.org/10.1182/blood-2008-01-135285
Stern M, Ruggeri L, Mancusi A, Bernardo ME, De Angelis C, Bucher C et al. Survival after T cell depleted haploidentical stem cell transplantation is improved using the mother as donor. Blood. 2008 Oct 1;112(7):2990-2995. https://doi.org/10.1182/blood-2008-01-135285
Stern, Martin ; Ruggeri, Loredana ; Mancusi, Antonella ; Bernardo, Maria Ester ; De Angelis, Claudia ; Bucher, Christoph ; Locatelli, Franco ; Aversa, Franco ; Velardi, Andrea. / Survival after T cell depleted haploidentical stem cell transplantation is improved using the mother as donor. In: Blood. 2008 ; Vol. 112, No. 7. pp. 2990-2995.
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