Abstract
We studied survival and disease complications in 1146 patients with thalassemia major, born from January 1, 1960 to December 31, 1987. At last follow-up, in March 1997, probability of survival to age 20 years was 89% and to age 25 years was 82% for patients born in the years 1970-1974. Patients who died had a serum ferritin level, measured the year before death, significantly higher than those who survived. Diabetes was present in 5.4% of the patients; heart failure in 6.4%, arrhythmias in 5.0%, thrombosis in 1.1%, hypothyroidism in 11.6%, HIV infection in 1.8%. Hypogonadism was diagnosed in 55% of 578 patients who had reached pubertal age: 83.5% of hypogonadic females and 78.6% of males were receiving substitutive hormonal therapy. In conclusion, the survival of patients with thalassemia major is good and improving, but the prevalence of severe complications is still high.
| Original language | English |
|---|---|
| Pages (from-to) | 227-231 |
| Number of pages | 5 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 850 |
| DOIs | |
| Publication status | Published - 1998 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Survival and disease complications in thalassemia major. / Borgna-Pignatti, Caterina; Rugolotto, Simone; De Stefano, Piero; Piga, Antonio; Di Gregorio, Felicia; Gamberini, Maria Rita; Sabato, Vincenzo; Melevendi, Caterina; Cappellini, Maria Domenica; Verlato, Giuseppe.
In: Annals of the New York Academy of Sciences, Vol. 850, 1998, p. 227-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Survival and disease complications in thalassemia major
AU - Borgna-Pignatti, Caterina
AU - Rugolotto, Simone
AU - De Stefano, Piero
AU - Piga, Antonio
AU - Di Gregorio, Felicia
AU - Gamberini, Maria Rita
AU - Sabato, Vincenzo
AU - Melevendi, Caterina
AU - Cappellini, Maria Domenica
AU - Verlato, Giuseppe
PY - 1998
Y1 - 1998
N2 - We studied survival and disease complications in 1146 patients with thalassemia major, born from January 1, 1960 to December 31, 1987. At last follow-up, in March 1997, probability of survival to age 20 years was 89% and to age 25 years was 82% for patients born in the years 1970-1974. Patients who died had a serum ferritin level, measured the year before death, significantly higher than those who survived. Diabetes was present in 5.4% of the patients; heart failure in 6.4%, arrhythmias in 5.0%, thrombosis in 1.1%, hypothyroidism in 11.6%, HIV infection in 1.8%. Hypogonadism was diagnosed in 55% of 578 patients who had reached pubertal age: 83.5% of hypogonadic females and 78.6% of males were receiving substitutive hormonal therapy. In conclusion, the survival of patients with thalassemia major is good and improving, but the prevalence of severe complications is still high.
AB - We studied survival and disease complications in 1146 patients with thalassemia major, born from January 1, 1960 to December 31, 1987. At last follow-up, in March 1997, probability of survival to age 20 years was 89% and to age 25 years was 82% for patients born in the years 1970-1974. Patients who died had a serum ferritin level, measured the year before death, significantly higher than those who survived. Diabetes was present in 5.4% of the patients; heart failure in 6.4%, arrhythmias in 5.0%, thrombosis in 1.1%, hypothyroidism in 11.6%, HIV infection in 1.8%. Hypogonadism was diagnosed in 55% of 578 patients who had reached pubertal age: 83.5% of hypogonadic females and 78.6% of males were receiving substitutive hormonal therapy. In conclusion, the survival of patients with thalassemia major is good and improving, but the prevalence of severe complications is still high.
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U2 - 10.1111/j.1749-6632.1998.tb10479.x
DO - 10.1111/j.1749-6632.1998.tb10479.x
M3 - Article
VL - 850
SP - 227
EP - 231
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -