Survival and neurological outcomes after nasopharyngeal cooling or peripheral vein cold saline infusion initiated during cardiopulmonary resuscitation in a porcine model of prolonged cardiac arrest

Tao Yu, Denise Barbut, Giuseppe Ristagno, Jun Hwi Cho, Shijie Sun, Yongqin Li, Max Harry Weil, Wanchun Tang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objective: We have previously demonstrated that nasopharyngeal cooling initiated during cardiopulmonary resuscitation improves the success of resuscitation. In this study, we compared the effects of nasopharyngeal cooling with cold saline infusion initiated during cardiopulmonary resuscitation on resuscitation outcome in a porcine model of prolonged cardiac arrest. We hypothesized that nasopharyngeal cooling initiated during cardiopulmonary resuscitation would yield better resuscitation outcome when compared with cold saline infusion. Design: Randomized, prospective animal study. Setting: University-affiliated research laboratory. Subjects: Yorkshire-X domestic pigs (Sus scrofa). Interventions: Ventricular fibrillation was induced in 14 pigs weighing 38 ± 2 kg. After 15 mins of untreated ventricular fibrillation, cardiopulmonary resuscitation was performed for 5 mins before defibrillation. Coincident with the start of cardiopulmonary resuscitation, animals were randomly assigned to receive nasopharyngeal cooling with the aid of the RhinoChill Device (BeneChill, San Diego, CA) or cold saline infusion with 30 mL/kg 4°C saline. One hour after restoration of spontaneous circulation, surface cooling was begun with the aid of a water blanket in both groups and Maintained for 4 hrs. Measurements and Main Results: Jugular vein temperature significantly decreased in animals subjected to nasopharyngeal cooling in comparison with those receiving cold saline infusion (p

Original languageEnglish
Pages (from-to)916-921
Number of pages6
JournalCritical Care Medicine
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Cardiopulmonary Resuscitation
Heart Arrest
Veins
Swine
Resuscitation
Sus scrofa
Ventricular Fibrillation
Jugular Veins
Prospective Studies
Equipment and Supplies
Temperature
Water
Research

Keywords

  • Cardiac arrest
  • Cardiopulmonary resuscitation
  • Hypothermia
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Survival and neurological outcomes after nasopharyngeal cooling or peripheral vein cold saline infusion initiated during cardiopulmonary resuscitation in a porcine model of prolonged cardiac arrest. / Yu, Tao; Barbut, Denise; Ristagno, Giuseppe; Cho, Jun Hwi; Sun, Shijie; Li, Yongqin; Weil, Max Harry; Tang, Wanchun.

In: Critical Care Medicine, Vol. 38, No. 3, 03.2010, p. 916-921.

Research output: Contribution to journalArticle

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