Survival Benefit of the Primary Prevention Implantable Cardioverter-Defibrillator among Older Patients: Does Age Matter? An Analysis of Pooled Data from 5 Clinical Trials

Paul L. Hess, Sana M. Al-Khatib, Joo Y. Han, Rex Edwards, Gust H. Bardy, J. Thomas Bigger, Alfred Buxton, Riccardo Cappato, Paul Dorian, Al Hallstrom, Alan H. Kadish, Peter J. Kudenchuk, Kerry L. Lee, Daniel B. Mark, Arthur J. Moss, Richard Steinman, Lurdes Y T Inoue, Gillian Sanders

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The impact of patient age on the risks of death or rehospitalization after primary prevention implantable cardioverter-defibrillator (ICD) placement is uncertain. Methods and Results-Data from 5 major ICD trials were merged: the Multicenter Automatic Defibrillator Implantation Trial I (MADIT-I), the Multicenter UnSustained Tachycardia Trial (MUSTT), the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II), the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Trial (DEFINITE), and the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). Median age at enrollment was 62 (interquartile range 53-70) years. Compared with their younger counterparts, older patients had a greater burden of comorbid illness. In unadjusted exploratory analyses, ICD recipients were less likely to die than nonrecipients in all age groups: among patients aged

Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalCirculation: Cardiovascular Quality and Outcomes
Volume8
Issue number2
DOIs
Publication statusPublished - Mar 21 2015

Fingerprint

Defibrillators
Implantable Defibrillators
Primary Prevention
Clinical Trials
Multicenter Studies
Survival
Cost of Illness
Sudden Cardiac Death
Cardiomyopathies
Tachycardia
Heart Failure
Age Groups
Therapeutics

Keywords

  • Aging
  • defibrillators
  • implantable
  • meta-analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Survival Benefit of the Primary Prevention Implantable Cardioverter-Defibrillator among Older Patients : Does Age Matter? An Analysis of Pooled Data from 5 Clinical Trials. / Hess, Paul L.; Al-Khatib, Sana M.; Han, Joo Y.; Edwards, Rex; Bardy, Gust H.; Bigger, J. Thomas; Buxton, Alfred; Cappato, Riccardo; Dorian, Paul; Hallstrom, Al; Kadish, Alan H.; Kudenchuk, Peter J.; Lee, Kerry L.; Mark, Daniel B.; Moss, Arthur J.; Steinman, Richard; Inoue, Lurdes Y T; Sanders, Gillian.

In: Circulation: Cardiovascular Quality and Outcomes, Vol. 8, No. 2, 21.03.2015, p. 179-186.

Research output: Contribution to journalArticle

Hess, PL, Al-Khatib, SM, Han, JY, Edwards, R, Bardy, GH, Bigger, JT, Buxton, A, Cappato, R, Dorian, P, Hallstrom, A, Kadish, AH, Kudenchuk, PJ, Lee, KL, Mark, DB, Moss, AJ, Steinman, R, Inoue, LYT & Sanders, G 2015, 'Survival Benefit of the Primary Prevention Implantable Cardioverter-Defibrillator among Older Patients: Does Age Matter? An Analysis of Pooled Data from 5 Clinical Trials', Circulation: Cardiovascular Quality and Outcomes, vol. 8, no. 2, pp. 179-186. https://doi.org/10.1161/CIRCOUTCOMES.114.001306
Hess, Paul L. ; Al-Khatib, Sana M. ; Han, Joo Y. ; Edwards, Rex ; Bardy, Gust H. ; Bigger, J. Thomas ; Buxton, Alfred ; Cappato, Riccardo ; Dorian, Paul ; Hallstrom, Al ; Kadish, Alan H. ; Kudenchuk, Peter J. ; Lee, Kerry L. ; Mark, Daniel B. ; Moss, Arthur J. ; Steinman, Richard ; Inoue, Lurdes Y T ; Sanders, Gillian. / Survival Benefit of the Primary Prevention Implantable Cardioverter-Defibrillator among Older Patients : Does Age Matter? An Analysis of Pooled Data from 5 Clinical Trials. In: Circulation: Cardiovascular Quality and Outcomes. 2015 ; Vol. 8, No. 2. pp. 179-186.
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