Survival factors in 186 patients younger than 40 years old with colorectal adenocarcinoma

James C. Cusack, Geoffrey G. Giacco, Karen Cleary, B. Scott Davidson, Francesco Izzo, John Skibber, Julia Yen, Steven A. Curley

Research output: Contribution to journalArticlepeer-review


BACKGROUND: We sought to determine the clinical factors and tumor characteristics associated with the reported poor prognosis in young patients with carcinoma of the colon and rectum. STUDY DESIGN: A retrospective review was performed of 186 patients younger than 40 years of age who were treated for primary colorectal adenocarcinoma. The median age was 34.3 years, and the median follow-up period was 9.4 years. Clinical and tumor histopathologic parameters were analyzed. RESULTS: Regional lymph node metastases, distant metastases, or both, were seen at first examination in 65.6 percent of young patients. Histopathologic indicators of more aggressive tumor biology were present at a significantly higher frequency in young patients compared with patients older than 40 years (p

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalJournal of the American College of Surgeons
Issue number2
Publication statusPublished - Aug 1996

ASJC Scopus subject areas

  • Surgery

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