Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE ε4 allele

Claudia Giannattasio, Anna Poleggi, Maria Puopolo, Maurizio Pocchiari, Piero Antuono, Gloria Dal Forno, David R. Wekstein, Maria G. Matera, Davide Seripa, Adele Acciarri, Alessandra Bizzarro, Alessandra Lauria, Carlo Masullo

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer's disease patients. Analyses of survival showed that the absence of the APOE ε4 allele in heterozygous codon 129 PRNP carriers is a negative predictor of survival. When this subgroup of patients was stratified by sex, the effect of APOE was observed in women, but not in men.

Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume25
Issue number4
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Alzheimer's disease
  • APOE genotype
  • Codon 129
  • Prion protein polymorphism

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

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