Survival in patients with uveal melanoma in Europe

Gianni Virgili, Gemma Gatta, Laura Ciccolallo, Riccardo Capocaccia, Annibale Biggeri, Emanuele Crocetti, Jean Michel Lutz, Eugenio Paci

Research output: Contribution to journalArticle

Abstract

Objective: To estimate survival in patients in whom uveal melanoma was diagnosed between January 1, 1983, and December 31, 1994, in Europe. Methods: Survival analysis of data from 32 cancer registries in 16 European countries adhering to the European Cancer Registry for 5788 patients with uveal melanoma diagnosed between January 1, 1983, and December 31, 1994, with follow-up to 1999. Results: Five-year relative survival was 68.9% overall and remained stable with the period of diagnosis. Relative excess risk of death was 2.45 (95% confidence interval [CI], 2.10-2.86) in patients aged 75 years or older compared with patients aged 54 years or younger and was slightly higher in male patients (relative excess risk, 1.10; 95% CI, 1.02-1.19) than in female patients. Survival was similar in Nordic countries (relative excess risk, 1.03; 95% CI, 0.87-1.21) compared with the United Kingdom (reference country) and was lower in eastern and western European countries (1.26; 1.05-1.52, and 1.25; 0.90-1.60, respectively) compared with the reference country. Conclusions: In this large series of patients with uveal melanoma, 5-year relative survival remained stable with the introduction of conservative treatment in individuals in whom uveal melanoma was diagnosed between 1983 and 1994. We found differences in survival between sexes and in European areas that should be investigated in studies that consider tumor characteristics at the individual level.

Original languageEnglish
Pages (from-to)1413-1418
Number of pages6
JournalArchives of Ophthalmology
Volume126
Issue number10
DOIs
Publication statusPublished - Oct 2008

Fingerprint

Survival
Confidence Intervals
Registries
Scandinavian and Nordic Countries
Neoplasms
Survival Analysis
Uveal melanoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Virgili, G., Gatta, G., Ciccolallo, L., Capocaccia, R., Biggeri, A., Crocetti, E., ... Paci, E. (2008). Survival in patients with uveal melanoma in Europe. Archives of Ophthalmology, 126(10), 1413-1418. https://doi.org/10.1001/archopht.126.10.1413

Survival in patients with uveal melanoma in Europe. / Virgili, Gianni; Gatta, Gemma; Ciccolallo, Laura; Capocaccia, Riccardo; Biggeri, Annibale; Crocetti, Emanuele; Lutz, Jean Michel; Paci, Eugenio.

In: Archives of Ophthalmology, Vol. 126, No. 10, 10.2008, p. 1413-1418.

Research output: Contribution to journalArticle

Virgili, G, Gatta, G, Ciccolallo, L, Capocaccia, R, Biggeri, A, Crocetti, E, Lutz, JM & Paci, E 2008, 'Survival in patients with uveal melanoma in Europe', Archives of Ophthalmology, vol. 126, no. 10, pp. 1413-1418. https://doi.org/10.1001/archopht.126.10.1413
Virgili G, Gatta G, Ciccolallo L, Capocaccia R, Biggeri A, Crocetti E et al. Survival in patients with uveal melanoma in Europe. Archives of Ophthalmology. 2008 Oct;126(10):1413-1418. https://doi.org/10.1001/archopht.126.10.1413
Virgili, Gianni ; Gatta, Gemma ; Ciccolallo, Laura ; Capocaccia, Riccardo ; Biggeri, Annibale ; Crocetti, Emanuele ; Lutz, Jean Michel ; Paci, Eugenio. / Survival in patients with uveal melanoma in Europe. In: Archives of Ophthalmology. 2008 ; Vol. 126, No. 10. pp. 1413-1418.
@article{fdf13027effd4c03a47df71532b378f9,
title = "Survival in patients with uveal melanoma in Europe",
abstract = "Objective: To estimate survival in patients in whom uveal melanoma was diagnosed between January 1, 1983, and December 31, 1994, in Europe. Methods: Survival analysis of data from 32 cancer registries in 16 European countries adhering to the European Cancer Registry for 5788 patients with uveal melanoma diagnosed between January 1, 1983, and December 31, 1994, with follow-up to 1999. Results: Five-year relative survival was 68.9{\%} overall and remained stable with the period of diagnosis. Relative excess risk of death was 2.45 (95{\%} confidence interval [CI], 2.10-2.86) in patients aged 75 years or older compared with patients aged 54 years or younger and was slightly higher in male patients (relative excess risk, 1.10; 95{\%} CI, 1.02-1.19) than in female patients. Survival was similar in Nordic countries (relative excess risk, 1.03; 95{\%} CI, 0.87-1.21) compared with the United Kingdom (reference country) and was lower in eastern and western European countries (1.26; 1.05-1.52, and 1.25; 0.90-1.60, respectively) compared with the reference country. Conclusions: In this large series of patients with uveal melanoma, 5-year relative survival remained stable with the introduction of conservative treatment in individuals in whom uveal melanoma was diagnosed between 1983 and 1994. We found differences in survival between sexes and in European areas that should be investigated in studies that consider tumor characteristics at the individual level.",
author = "Gianni Virgili and Gemma Gatta and Laura Ciccolallo and Riccardo Capocaccia and Annibale Biggeri and Emanuele Crocetti and Lutz, {Jean Michel} and Eugenio Paci",
year = "2008",
month = "10",
doi = "10.1001/archopht.126.10.1413",
language = "English",
volume = "126",
pages = "1413--1418",
journal = "Archives of Ophthalmology",
issn = "0003-9950",
publisher = "American Medical Association",
number = "10",

}

TY - JOUR

T1 - Survival in patients with uveal melanoma in Europe

AU - Virgili, Gianni

AU - Gatta, Gemma

AU - Ciccolallo, Laura

AU - Capocaccia, Riccardo

AU - Biggeri, Annibale

AU - Crocetti, Emanuele

AU - Lutz, Jean Michel

AU - Paci, Eugenio

PY - 2008/10

Y1 - 2008/10

N2 - Objective: To estimate survival in patients in whom uveal melanoma was diagnosed between January 1, 1983, and December 31, 1994, in Europe. Methods: Survival analysis of data from 32 cancer registries in 16 European countries adhering to the European Cancer Registry for 5788 patients with uveal melanoma diagnosed between January 1, 1983, and December 31, 1994, with follow-up to 1999. Results: Five-year relative survival was 68.9% overall and remained stable with the period of diagnosis. Relative excess risk of death was 2.45 (95% confidence interval [CI], 2.10-2.86) in patients aged 75 years or older compared with patients aged 54 years or younger and was slightly higher in male patients (relative excess risk, 1.10; 95% CI, 1.02-1.19) than in female patients. Survival was similar in Nordic countries (relative excess risk, 1.03; 95% CI, 0.87-1.21) compared with the United Kingdom (reference country) and was lower in eastern and western European countries (1.26; 1.05-1.52, and 1.25; 0.90-1.60, respectively) compared with the reference country. Conclusions: In this large series of patients with uveal melanoma, 5-year relative survival remained stable with the introduction of conservative treatment in individuals in whom uveal melanoma was diagnosed between 1983 and 1994. We found differences in survival between sexes and in European areas that should be investigated in studies that consider tumor characteristics at the individual level.

AB - Objective: To estimate survival in patients in whom uveal melanoma was diagnosed between January 1, 1983, and December 31, 1994, in Europe. Methods: Survival analysis of data from 32 cancer registries in 16 European countries adhering to the European Cancer Registry for 5788 patients with uveal melanoma diagnosed between January 1, 1983, and December 31, 1994, with follow-up to 1999. Results: Five-year relative survival was 68.9% overall and remained stable with the period of diagnosis. Relative excess risk of death was 2.45 (95% confidence interval [CI], 2.10-2.86) in patients aged 75 years or older compared with patients aged 54 years or younger and was slightly higher in male patients (relative excess risk, 1.10; 95% CI, 1.02-1.19) than in female patients. Survival was similar in Nordic countries (relative excess risk, 1.03; 95% CI, 0.87-1.21) compared with the United Kingdom (reference country) and was lower in eastern and western European countries (1.26; 1.05-1.52, and 1.25; 0.90-1.60, respectively) compared with the reference country. Conclusions: In this large series of patients with uveal melanoma, 5-year relative survival remained stable with the introduction of conservative treatment in individuals in whom uveal melanoma was diagnosed between 1983 and 1994. We found differences in survival between sexes and in European areas that should be investigated in studies that consider tumor characteristics at the individual level.

UR - http://www.scopus.com/inward/record.url?scp=54049099236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54049099236&partnerID=8YFLogxK

U2 - 10.1001/archopht.126.10.1413

DO - 10.1001/archopht.126.10.1413

M3 - Article

C2 - 18852420

AN - SCOPUS:54049099236

VL - 126

SP - 1413

EP - 1418

JO - Archives of Ophthalmology

JF - Archives of Ophthalmology

SN - 0003-9950

IS - 10

ER -