Survival of 86,690 patients with thyroid cancer: A population-based study in 29 European countries from EUROCARE-5.

L Dal Maso, A Tavilla, F Pacini, D Serraino, B A C van Dijk, M D Chirlaque, R Capocaccia, N Larrañaga, M Colonna, D Agius, E Ardanaz, J Rubió-Casadevall, A Kowalska, S Virdone, S Mallone, H Amash, R De Angelis, EUROCARE-5 Working Group, Lucia Mangone, Massimo Vicentini

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Incidence rates of thyroid cancer (TC) increased in several countries during the last 30 years, while mortality rates remained unchanged, raising important questions for treatment and follow-up of TC patients. This study updates population-based estimates of relative survival (RS) after TC diagnosis in Europe by sex, country, age, period and histology.METHODS: Data from 87 cancer registries in 29 countries were extracted from the EUROCARE-5 dataset. One- and 5-year RS were estimated using the cohort approach for 86,690 adult TC patients diagnosed in 2000-2007 and followed-up to 12/31/2008. RS trends in 1999-2007 and 10-year RS in 2005-2007 were estimated using the period approach.RESULTS: In Europe 2000-2007, 5-year RS after TC was 88% in women and 81% in men. Survival rates varied by country and were strongly correlated (Pearson ρ = 75%) with country-specific incidence rates. Five-year RS decreased with age (in women from >95% at age 15-54 to 57% at age 75+), from 98% in women and 94% in men with papillary TC to 14% in women and 12% in men with anaplastic TC. Proportion of papillary TC varied by country and increased over time, while survival rates were similar across areas and periods. In 1999-2007, 5-year RS increased by five percentage points for all TCs but only by two for papillary and by four for follicular TC. Ten-year RS in 2005-2007 was 89% in women and 79% in men.CONCLUSIONS: The reported increasing TC survival trend and differences by area are mainly explained by the varying histological case-mix of cases.
Original languageEnglish
Pages (from-to)140-152
Number of pages13
JournalEuropean Journal of Cancer
Volume77
DOIs
Publication statusPublished - May 2017

Keywords

  • Adenocarcinoma, Follicular
  • Adolescent
  • Adult
  • Aged
  • Carcinoma
  • Carcinoma, Papillary
  • Diagnosis-Related Groups
  • Europe
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Registries
  • Residence Characteristics
  • Sex Distribution
  • Thyroid Neoplasms
  • Young Adult
  • Journal Article
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

Fingerprint Dive into the research topics of 'Survival of 86,690 patients with thyroid cancer: A population-based study in 29 European countries from EUROCARE-5.'. Together they form a unique fingerprint.

Cite this