Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)

Andrea Pession, Elisa Dama, Roberto Rondelli, Corrado Magnani, Marisa De Rosa, Franco Locatelli, Franca Fagioli, Riccardo Haupt, Momcilo Jankovic, Benedetto Terracini, Franco Merletti, Guido Pastore

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76% for lymphoproliferative disorders and 68% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.

Original languageEnglish
Pages (from-to)1282-1289
Number of pages8
JournalEuropean Journal of Cancer
Volume44
Issue number9
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Cancer registration
  • Childhood cancer
  • Gender
  • Italy
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)'. Together they form a unique fingerprint.

Cite this