Survival of Contemporary Patients With Non-metastatic Small-cell Carcinoma of Urinary Bladder, According to Alternative Treatment Modalities: Clinical Genitourinary Cancer

S. Luzzago, C. Palumbo, G. Rosiello, S. Knipper, A. Pecoraro, S. Nazzani, Z. Tian, G. Musi, E. Montanari, S.F. Shariat, F. Saad, A. Briganti, O. de Cobelli, P.I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The objective of this study was to test the effect of chemotherapy and/or radical cystectomy (RC) and/or radiotherapy (RT) on survival of patients with non-metastatic small-cell carcinoma of the urinary bladder (SCCUB). Materials and Methods: Within the Surveillance, Epidemiology, and End Results registry (2001-2016), we identified patients with non-metastatic (T1-4, N0, M0) SCCUB. Treatment was defined as: chemotherapy alone, chemotherapy + RC, and chemotherapy + RT. Temporal trends, cumulative incidence plots, and multivariable competing risks regression models were used. Results: Of 595 patients with SCCUB, 230 (38.5%), 159 (27%), and 206 (34.5%) were treated with chemotherapy alone, chemotherapy + RC, and chemotherapy + RT, respectively. The rates of chemotherapy + RC increased (estimated annual percentage changes [EAPC], +5.9%; P =.002). Conversely, chemotherapy alone (EAPC, −1.7%; P =.1) and chemotherapy + RT rates decreased (EAPC: −2.2%; P =.08). Overall, 5-year cancer-specific mortality (CSM) rates were 44%, 29%, and 40% for patients treated with chemotherapy alone, chemotherapy + RC, and chemotherapy + RT, respectively (P =.004). Relative to chemotherapy alone, patients treated with chemotherapy + RC experienced lower CSM (hazard ratio, 0.5; P
Original languageEnglish
Pages (from-to)e450-e456
JournalClin. Genitourin. Cancer
Volume18
Issue number4
DOIs
Publication statusPublished - 2020

Keywords

  • Bladder cancer
  • Cancer specific survival
  • Chemotherapy
  • Radical cystectomy
  • Radiotherapy
  • antineoplastic agent
  • adult
  • aged
  • Article
  • bladder carcinoma
  • cancer chemotherapy
  • cancer control
  • cancer incidence
  • cancer mortality
  • cancer specific survival
  • cancer survival
  • chemoradiotherapy
  • chemosurgery
  • cohort analysis
  • controlled study
  • cystectomy
  • female
  • hazard ratio
  • human
  • major clinical study
  • male
  • metastasis
  • multivariate analysis
  • rare disease
  • regression analysis
  • small cell carcinoma
  • small cell carcinoma of the urinary bladder
  • treatment outcome

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