Abstract
Population-based information on the survival of patients with myeloid malignancies is rare mainly because some entities were not recognized as malignant until the publication of the third revision of the International Classification of Diseases for Oncology and World Health Organization classification in 2000. In this study we report the survival of patients with myeloid malignancies, classified by updated criteria, in Europe. We analyzed 58,800 cases incident between 1995 to 2002 in 48 population-based cancer registries from 20 European countries, classified into HAEMACARE myeloid malignancy groupings. The period approach was used to estimate 5-year relative survival in 2000-2002. The relative overall survival rate was 37%, but varied significantly between the major groups: being 17% for acute myeloid leukemia, 20% for myelodysplastic/myeloproliferative neoplasms, 31% for myelodysplastic syndromes and 63% for myeloproliferative neoplasms. Survival of patients with individual disease entities ranged from 90% for those with essential thrombocythemia to 4% for those with acute myeloid leukemia with multilineage dysplasia. Regional European variations in survival were conspicuous for myeloproliferative neoplasms, with survival rates being lowest in Eastern Europe. This is the first paper to present large-scale, European survival data for patients with myeloid malignancies using prognosis-based groupings of entities defined by the third revision of the International Classification of Diseases for Oncology/World Health Organization classifications. Poor survival in some parts of Europe, particularly for treatable diseases such as chronic myeloid leukemia, is of concern for hematologists and public health authorities.
| Original language | English |
|---|---|
| Pages (from-to) | 230-238 |
| Number of pages | 9 |
| Journal | Haematologica |
| Volume | 98 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2013 |
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ASJC Scopus subject areas
- Hematology
- Medicine(all)
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Survival of European patients diagnosed with myeloid malignancies : A HAEMACARE study. / Maynadié, Marc; De Angelis, Roberta; Marcos-Gragera, Rafael; Visser, Otto; Allemani, Claudia; Tereanu, Carmen; Capocaccia, Riccardo; Giacomin, Adriano; Lutz, Jean Michel; Martos, Carmen; Sankila, Risto; Johannesen, Tom Børge; Simonetti, Arianna; Sant, Milena.
In: Haematologica, Vol. 98, No. 2, 01.02.2013, p. 230-238.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Survival of European patients diagnosed with myeloid malignancies
T2 - A HAEMACARE study
AU - Maynadié, Marc
AU - De Angelis, Roberta
AU - Marcos-Gragera, Rafael
AU - Visser, Otto
AU - Allemani, Claudia
AU - Tereanu, Carmen
AU - Capocaccia, Riccardo
AU - Giacomin, Adriano
AU - Lutz, Jean Michel
AU - Martos, Carmen
AU - Sankila, Risto
AU - Johannesen, Tom Børge
AU - Simonetti, Arianna
AU - Sant, Milena
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Population-based information on the survival of patients with myeloid malignancies is rare mainly because some entities were not recognized as malignant until the publication of the third revision of the International Classification of Diseases for Oncology and World Health Organization classification in 2000. In this study we report the survival of patients with myeloid malignancies, classified by updated criteria, in Europe. We analyzed 58,800 cases incident between 1995 to 2002 in 48 population-based cancer registries from 20 European countries, classified into HAEMACARE myeloid malignancy groupings. The period approach was used to estimate 5-year relative survival in 2000-2002. The relative overall survival rate was 37%, but varied significantly between the major groups: being 17% for acute myeloid leukemia, 20% for myelodysplastic/myeloproliferative neoplasms, 31% for myelodysplastic syndromes and 63% for myeloproliferative neoplasms. Survival of patients with individual disease entities ranged from 90% for those with essential thrombocythemia to 4% for those with acute myeloid leukemia with multilineage dysplasia. Regional European variations in survival were conspicuous for myeloproliferative neoplasms, with survival rates being lowest in Eastern Europe. This is the first paper to present large-scale, European survival data for patients with myeloid malignancies using prognosis-based groupings of entities defined by the third revision of the International Classification of Diseases for Oncology/World Health Organization classifications. Poor survival in some parts of Europe, particularly for treatable diseases such as chronic myeloid leukemia, is of concern for hematologists and public health authorities.
AB - Population-based information on the survival of patients with myeloid malignancies is rare mainly because some entities were not recognized as malignant until the publication of the third revision of the International Classification of Diseases for Oncology and World Health Organization classification in 2000. In this study we report the survival of patients with myeloid malignancies, classified by updated criteria, in Europe. We analyzed 58,800 cases incident between 1995 to 2002 in 48 population-based cancer registries from 20 European countries, classified into HAEMACARE myeloid malignancy groupings. The period approach was used to estimate 5-year relative survival in 2000-2002. The relative overall survival rate was 37%, but varied significantly between the major groups: being 17% for acute myeloid leukemia, 20% for myelodysplastic/myeloproliferative neoplasms, 31% for myelodysplastic syndromes and 63% for myeloproliferative neoplasms. Survival of patients with individual disease entities ranged from 90% for those with essential thrombocythemia to 4% for those with acute myeloid leukemia with multilineage dysplasia. Regional European variations in survival were conspicuous for myeloproliferative neoplasms, with survival rates being lowest in Eastern Europe. This is the first paper to present large-scale, European survival data for patients with myeloid malignancies using prognosis-based groupings of entities defined by the third revision of the International Classification of Diseases for Oncology/World Health Organization classifications. Poor survival in some parts of Europe, particularly for treatable diseases such as chronic myeloid leukemia, is of concern for hematologists and public health authorities.
UR - http://www.scopus.com/inward/record.url?scp=84875304372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875304372&partnerID=8YFLogxK
U2 - 10.3324/haematol.2012.064014
DO - 10.3324/haematol.2012.064014
M3 - Article
C2 - 22983589
AN - SCOPUS:84875304372
VL - 98
SP - 230
EP - 238
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 2
ER -