Survival of high grade glioma patients depends on their age at diagnosis

Gianluigi Casartelli, Alessandra Dorcaratto, Jean Louis Ravetti, Simona Sola, Alessandro Vitali, Domenico Franco Merlo, Guido Frosina

Research output: Contribution to journalArticlepeer-review


Background: Although the prognosis for malignant gliomas is normally dismal, it's not infrequent in neurooncologist's experience to find cases with unusually prolonged survival. In order to understand what factors influence survival of high grade glioma patients, a cohort of 196 high (III-IV) grade glioma patients was investigated for possible association between (1) survival and age at diagnosis; (2) survival and micronuclei in tumor tissue; (3) survival and gender; (4) micronuclei in tumor tissue and age at diagnosis. Results: Patients diagnosed at an older age (>64 years) had a significantly higher hazard as compared to younger patients (≤64 years), indicating that older patients survived shorter. On the contrary, no association was found between survival and micronuclei or gender. Methods: Survival analysis was performed by the Cox' proportional hazards regression model. Conclusions: Age at diagnosis, together with other established prognostic factors such as histologic characteristics, extent of surgery and Karnofsky Performance Score may to a certain extent predict survival of high grade glioma patients.

Original languageEnglish
Pages (from-to)1719-1721
Number of pages3
JournalCancer Biology and Therapy
Issue number18
Publication statusPublished - Sep 15 2009


  • Age
  • Brain tumors
  • Glioblastoma
  • Hazard
  • Micronuclei
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Oncology
  • Pharmacology


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