Survival of patients with spinal muscular atrophy type 1

Cesare Gregoretti, Giancarlo Ottonello, Maria Beatrice Chiarini Testa, Chiara Mastella, Lucilla Ravà, Elisabetta Bignamini, Aleksandar Veljkovic, Renato Cutrera

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Spinal muscular atrophy type 1 (SMA1) is a progressive disease and is usually fatal in the first year of life. METHODS: A retrospective chart review was performed of SMA1 patients and their outcomes according to the following choices: letting nature take its course (NT); tracheostomy and invasive mechanical ventilation (TV); continuous noninvasive respiratory muscle aid (NRA), including noninvasive ventilation; and mechanically assisted cough. RESULTS: Of 194 consecutively referred patients enrolled in this study (103 males, 91 females), NT, TV, and NRA were chosen for 121 (62.3%), 42 (21.7%), and 31 (16%) patients, respectively. Survival at ages 24 and 48 months was higher in TV than NRA users: 95% (95% confidence interval: 81.8%-98.8%) and 67.7% (95% confidence interval: 46.7%-82%) at age 24 months (P <.001) and 89.43% and 45% at age 48 months in the TV and NRA groups, respectively (P <.001). The choice of TV decreased from 50% (1992-1998) to 12.7% (2005-2010) (P <.005) with a nonstatistically significant increase for NT from 50% to 65%. The choice of NRA increased from 8.1% (1999-2004) to 22.7% (2005-2010) (P <.001). CONCLUSIONS: Long-term survival outcome is determined by the choice of the treatment. NRA and TV can prolong survival, with NRA showing a lower survival probability at ages 24 and 48 months.

Original languageEnglish
JournalPediatrics
Volume131
Issue number5
DOIs
Publication statusPublished - May 2013

Keywords

  • Home mechanical ventilation
  • Long survival
  • Mechanical assisted cough
  • Pediatric palliative care
  • Spinal muscular atrophy type 1

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Arts and Humanities (miscellaneous)

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