Survival of peritoneal malignant mesothelioma in Italy

A population-based study

Dario Mirabelli, Sara Roberti, Manuela Gangemi, Rosalba Rosato, Fulvio Ricceri, Enzo Merler, Valerio Gennaro, Lucia Mangone, Giuseppe Gorini, Cristiana Pascucci, Domenica Cavone, Carmela Nicita, Pietro Gino Barbieri, Alessandro Marinaccio, Corrado Magnani, Fabio Montanaro

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In some population-based studies, a shorter median survival was observed in peritoneal as compared with pleural, malignant mesothelioma, but in others, longer median survival times or higher proportions of long-term survivors were reported. Statistical instability could have caused these differences. We analyzed survival in peritoneal mesothelioma in a large and unselected population-based case series. Cases (338) registered from 1990 to 2001 by 9 Italian regional mesothelioma registries contributing to the network of the National Mesothelioma Registry were followed until December 31, 2005. Univariate (Kaplan-Meier) and multivariate (Cox proportional hazards regression) analyses of survival were performed according to selected individual characteristics, including limited treatment information in a subset of 194 cases. The results were compared with those obtained in a parallel study on pleural mesothelioma cases. Epithelioid histotype, younger age at diagnosis and, to a lesser degree, gender (women), and being diagnosed in a hospital with a thoracic surgery unit positively and significantly affected survival. The effect of treatment was positive but not statistically significant. No trend in the risk of death according to calendar period of diagnosis was present. Peritoneal mesothelioma cases had shorter median survival time than pleural cases, but a larger proportion of long-term survivors. Survival patterns after peritoneal and pleural mesothelioma differed markedly. Treatment was not associated with a statistically significant improvement in survival, but our study included cases first diagnosed before the introduction of the most recent therapeutic approaches. This provides a large historical comparison for future studies on survival trends at the population level.

Original languageEnglish
Pages (from-to)194-200
Number of pages7
JournalInternational Journal of Cancer
Volume124
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

Fingerprint

Italy
Mesothelioma
Survival
Population
Survivors
Registries
Malignant Mesothelioma
Therapeutics
Thoracic Surgery
Regression Analysis

Keywords

  • Malignant mesothelioma
  • Peritoneum
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Mirabelli, D., Roberti, S., Gangemi, M., Rosato, R., Ricceri, F., Merler, E., ... Montanaro, F. (2009). Survival of peritoneal malignant mesothelioma in Italy: A population-based study. International Journal of Cancer, 124(1), 194-200. https://doi.org/10.1002/ijc.23866

Survival of peritoneal malignant mesothelioma in Italy : A population-based study. / Mirabelli, Dario; Roberti, Sara; Gangemi, Manuela; Rosato, Rosalba; Ricceri, Fulvio; Merler, Enzo; Gennaro, Valerio; Mangone, Lucia; Gorini, Giuseppe; Pascucci, Cristiana; Cavone, Domenica; Nicita, Carmela; Barbieri, Pietro Gino; Marinaccio, Alessandro; Magnani, Corrado; Montanaro, Fabio.

In: International Journal of Cancer, Vol. 124, No. 1, 01.01.2009, p. 194-200.

Research output: Contribution to journalArticle

Mirabelli, D, Roberti, S, Gangemi, M, Rosato, R, Ricceri, F, Merler, E, Gennaro, V, Mangone, L, Gorini, G, Pascucci, C, Cavone, D, Nicita, C, Barbieri, PG, Marinaccio, A, Magnani, C & Montanaro, F 2009, 'Survival of peritoneal malignant mesothelioma in Italy: A population-based study', International Journal of Cancer, vol. 124, no. 1, pp. 194-200. https://doi.org/10.1002/ijc.23866
Mirabelli D, Roberti S, Gangemi M, Rosato R, Ricceri F, Merler E et al. Survival of peritoneal malignant mesothelioma in Italy: A population-based study. International Journal of Cancer. 2009 Jan 1;124(1):194-200. https://doi.org/10.1002/ijc.23866
Mirabelli, Dario ; Roberti, Sara ; Gangemi, Manuela ; Rosato, Rosalba ; Ricceri, Fulvio ; Merler, Enzo ; Gennaro, Valerio ; Mangone, Lucia ; Gorini, Giuseppe ; Pascucci, Cristiana ; Cavone, Domenica ; Nicita, Carmela ; Barbieri, Pietro Gino ; Marinaccio, Alessandro ; Magnani, Corrado ; Montanaro, Fabio. / Survival of peritoneal malignant mesothelioma in Italy : A population-based study. In: International Journal of Cancer. 2009 ; Vol. 124, No. 1. pp. 194-200.
@article{d979713bd0e441c5a7a3e86822f529cd,
title = "Survival of peritoneal malignant mesothelioma in Italy: A population-based study",
abstract = "In some population-based studies, a shorter median survival was observed in peritoneal as compared with pleural, malignant mesothelioma, but in others, longer median survival times or higher proportions of long-term survivors were reported. Statistical instability could have caused these differences. We analyzed survival in peritoneal mesothelioma in a large and unselected population-based case series. Cases (338) registered from 1990 to 2001 by 9 Italian regional mesothelioma registries contributing to the network of the National Mesothelioma Registry were followed until December 31, 2005. Univariate (Kaplan-Meier) and multivariate (Cox proportional hazards regression) analyses of survival were performed according to selected individual characteristics, including limited treatment information in a subset of 194 cases. The results were compared with those obtained in a parallel study on pleural mesothelioma cases. Epithelioid histotype, younger age at diagnosis and, to a lesser degree, gender (women), and being diagnosed in a hospital with a thoracic surgery unit positively and significantly affected survival. The effect of treatment was positive but not statistically significant. No trend in the risk of death according to calendar period of diagnosis was present. Peritoneal mesothelioma cases had shorter median survival time than pleural cases, but a larger proportion of long-term survivors. Survival patterns after peritoneal and pleural mesothelioma differed markedly. Treatment was not associated with a statistically significant improvement in survival, but our study included cases first diagnosed before the introduction of the most recent therapeutic approaches. This provides a large historical comparison for future studies on survival trends at the population level.",
keywords = "Malignant mesothelioma, Peritoneum, Survival",
author = "Dario Mirabelli and Sara Roberti and Manuela Gangemi and Rosalba Rosato and Fulvio Ricceri and Enzo Merler and Valerio Gennaro and Lucia Mangone and Giuseppe Gorini and Cristiana Pascucci and Domenica Cavone and Carmela Nicita and Barbieri, {Pietro Gino} and Alessandro Marinaccio and Corrado Magnani and Fabio Montanaro",
year = "2009",
month = "1",
day = "1",
doi = "10.1002/ijc.23866",
language = "English",
volume = "124",
pages = "194--200",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Survival of peritoneal malignant mesothelioma in Italy

T2 - A population-based study

AU - Mirabelli, Dario

AU - Roberti, Sara

AU - Gangemi, Manuela

AU - Rosato, Rosalba

AU - Ricceri, Fulvio

AU - Merler, Enzo

AU - Gennaro, Valerio

AU - Mangone, Lucia

AU - Gorini, Giuseppe

AU - Pascucci, Cristiana

AU - Cavone, Domenica

AU - Nicita, Carmela

AU - Barbieri, Pietro Gino

AU - Marinaccio, Alessandro

AU - Magnani, Corrado

AU - Montanaro, Fabio

PY - 2009/1/1

Y1 - 2009/1/1

N2 - In some population-based studies, a shorter median survival was observed in peritoneal as compared with pleural, malignant mesothelioma, but in others, longer median survival times or higher proportions of long-term survivors were reported. Statistical instability could have caused these differences. We analyzed survival in peritoneal mesothelioma in a large and unselected population-based case series. Cases (338) registered from 1990 to 2001 by 9 Italian regional mesothelioma registries contributing to the network of the National Mesothelioma Registry were followed until December 31, 2005. Univariate (Kaplan-Meier) and multivariate (Cox proportional hazards regression) analyses of survival were performed according to selected individual characteristics, including limited treatment information in a subset of 194 cases. The results were compared with those obtained in a parallel study on pleural mesothelioma cases. Epithelioid histotype, younger age at diagnosis and, to a lesser degree, gender (women), and being diagnosed in a hospital with a thoracic surgery unit positively and significantly affected survival. The effect of treatment was positive but not statistically significant. No trend in the risk of death according to calendar period of diagnosis was present. Peritoneal mesothelioma cases had shorter median survival time than pleural cases, but a larger proportion of long-term survivors. Survival patterns after peritoneal and pleural mesothelioma differed markedly. Treatment was not associated with a statistically significant improvement in survival, but our study included cases first diagnosed before the introduction of the most recent therapeutic approaches. This provides a large historical comparison for future studies on survival trends at the population level.

AB - In some population-based studies, a shorter median survival was observed in peritoneal as compared with pleural, malignant mesothelioma, but in others, longer median survival times or higher proportions of long-term survivors were reported. Statistical instability could have caused these differences. We analyzed survival in peritoneal mesothelioma in a large and unselected population-based case series. Cases (338) registered from 1990 to 2001 by 9 Italian regional mesothelioma registries contributing to the network of the National Mesothelioma Registry were followed until December 31, 2005. Univariate (Kaplan-Meier) and multivariate (Cox proportional hazards regression) analyses of survival were performed according to selected individual characteristics, including limited treatment information in a subset of 194 cases. The results were compared with those obtained in a parallel study on pleural mesothelioma cases. Epithelioid histotype, younger age at diagnosis and, to a lesser degree, gender (women), and being diagnosed in a hospital with a thoracic surgery unit positively and significantly affected survival. The effect of treatment was positive but not statistically significant. No trend in the risk of death according to calendar period of diagnosis was present. Peritoneal mesothelioma cases had shorter median survival time than pleural cases, but a larger proportion of long-term survivors. Survival patterns after peritoneal and pleural mesothelioma differed markedly. Treatment was not associated with a statistically significant improvement in survival, but our study included cases first diagnosed before the introduction of the most recent therapeutic approaches. This provides a large historical comparison for future studies on survival trends at the population level.

KW - Malignant mesothelioma

KW - Peritoneum

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=58149402923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149402923&partnerID=8YFLogxK

U2 - 10.1002/ijc.23866

DO - 10.1002/ijc.23866

M3 - Article

VL - 124

SP - 194

EP - 200

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 1

ER -