Survival of women with cancers of breast and genital organs in Europe 1999-2007

Results of the EUROCARE-5 study

Milena Sant, Maria Dolores Chirlaque Lopez, Roberto Agresti, Maria José Sánchez Pérez, Bernd Holleczek, Magdalena Bielska-Lasota, Nadya Dimitrova, Kaire Innos, Alexander Katalinic, Hilde Langseth, Nerea Larrañaga, Silvia Rossi, Sabine Siesling, Pamela Minicozzi

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Background Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, vagina and vulva have been documented by previous EUROCARE studies. In the present EUROCARE-5 study we update survival estimates and investigate changes in country-specific and over time survival, discussing their relationship with incidence and mortality dynamics for cancers for which organised screening programs are ongoing. Methods We analysed cases archived in over 80 population-based cancer registries in 29 countries grouped into five European regions. We used the cohort approach to estimate 5-year relative survival (RS) for adult (≥15 years) women diagnosed 2000-2007, by age, country and region; and the period approach to estimate time trends (1999-2007) in RS for breast and cervical cancers. Results In 2000-2007, 5-year RS was 57% overall, 82% for women diagnosed with breast, 76% with corpus uteri, 62% with cervical, 38% with ovarian, 40% with vaginal and 62% with vulvar cancer. Survival was low for patients resident in Eastern Europe (34% ovary-74% breast) and Ireland and the United Kingdom [Ireland/UK] (31-79%) and high for those resident in Northern Europe (41-85%) except Denmark. Survival decreased with advancing age: markedly for women with ovarian (71% 15-44 years; 20% ≥75 years) and breast (86%; 72%) cancers. Survival for patients with breast and cervical cancers increased from 1999-2001 to 2005-2007, remarkably for those resident in countries with initially low survival. Conclusions Despite increases over time, survival for women's cancers remained poor in Eastern Europe, likely due to advanced stage at diagnosis and/or suboptimum access to adequate care. Low survival for women living in Ireland/UK and Denmark could indicate late detection, possibly related also to referral delay. Poor survival for ovarian cancer across the continent and over time suggests the need for a major research effort to improve prognosis for this common cancer.

Original languageEnglish
Pages (from-to)2191-2205
Number of pages15
JournalEuropean Journal of Cancer
Volume51
Issue number15
DOIs
Publication statusPublished - Oct 1 2015

Fingerprint

Genitalia
Breast Neoplasms
Survival
Eastern Europe
Breast
Denmark
Neoplasms
Ireland
Uterine Cervical Neoplasms
Ovary
Vulvar Neoplasms
Uterine Neoplasms
Vulva
Vagina
Cervix Uteri
Ovarian Neoplasms
Uterus
Registries
Referral and Consultation

Keywords

  • Breast cancer
  • Cervical cancer
  • Corpus uteri cancer
  • Europe
  • Ovarian cancer
  • Population-based
  • Survival
  • Vaginal cancer
  • Vulval cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sant, M., Chirlaque Lopez, M. D., Agresti, R., Sánchez Pérez, M. J., Holleczek, B., Bielska-Lasota, M., ... Minicozzi, P. (2015). Survival of women with cancers of breast and genital organs in Europe 1999-2007: Results of the EUROCARE-5 study. European Journal of Cancer, 51(15), 2191-2205. https://doi.org/10.1016/j.ejca.2015.07.022

Survival of women with cancers of breast and genital organs in Europe 1999-2007 : Results of the EUROCARE-5 study. / Sant, Milena; Chirlaque Lopez, Maria Dolores; Agresti, Roberto; Sánchez Pérez, Maria José; Holleczek, Bernd; Bielska-Lasota, Magdalena; Dimitrova, Nadya; Innos, Kaire; Katalinic, Alexander; Langseth, Hilde; Larrañaga, Nerea; Rossi, Silvia; Siesling, Sabine; Minicozzi, Pamela.

In: European Journal of Cancer, Vol. 51, No. 15, 01.10.2015, p. 2191-2205.

Research output: Contribution to journalArticle

Sant, M, Chirlaque Lopez, MD, Agresti, R, Sánchez Pérez, MJ, Holleczek, B, Bielska-Lasota, M, Dimitrova, N, Innos, K, Katalinic, A, Langseth, H, Larrañaga, N, Rossi, S, Siesling, S & Minicozzi, P 2015, 'Survival of women with cancers of breast and genital organs in Europe 1999-2007: Results of the EUROCARE-5 study', European Journal of Cancer, vol. 51, no. 15, pp. 2191-2205. https://doi.org/10.1016/j.ejca.2015.07.022
Sant, Milena ; Chirlaque Lopez, Maria Dolores ; Agresti, Roberto ; Sánchez Pérez, Maria José ; Holleczek, Bernd ; Bielska-Lasota, Magdalena ; Dimitrova, Nadya ; Innos, Kaire ; Katalinic, Alexander ; Langseth, Hilde ; Larrañaga, Nerea ; Rossi, Silvia ; Siesling, Sabine ; Minicozzi, Pamela. / Survival of women with cancers of breast and genital organs in Europe 1999-2007 : Results of the EUROCARE-5 study. In: European Journal of Cancer. 2015 ; Vol. 51, No. 15. pp. 2191-2205.
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abstract = "Background Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, vagina and vulva have been documented by previous EUROCARE studies. In the present EUROCARE-5 study we update survival estimates and investigate changes in country-specific and over time survival, discussing their relationship with incidence and mortality dynamics for cancers for which organised screening programs are ongoing. Methods We analysed cases archived in over 80 population-based cancer registries in 29 countries grouped into five European regions. We used the cohort approach to estimate 5-year relative survival (RS) for adult (≥15 years) women diagnosed 2000-2007, by age, country and region; and the period approach to estimate time trends (1999-2007) in RS for breast and cervical cancers. Results In 2000-2007, 5-year RS was 57{\%} overall, 82{\%} for women diagnosed with breast, 76{\%} with corpus uteri, 62{\%} with cervical, 38{\%} with ovarian, 40{\%} with vaginal and 62{\%} with vulvar cancer. Survival was low for patients resident in Eastern Europe (34{\%} ovary-74{\%} breast) and Ireland and the United Kingdom [Ireland/UK] (31-79{\%}) and high for those resident in Northern Europe (41-85{\%}) except Denmark. Survival decreased with advancing age: markedly for women with ovarian (71{\%} 15-44 years; 20{\%} ≥75 years) and breast (86{\%}; 72{\%}) cancers. Survival for patients with breast and cervical cancers increased from 1999-2001 to 2005-2007, remarkably for those resident in countries with initially low survival. Conclusions Despite increases over time, survival for women's cancers remained poor in Eastern Europe, likely due to advanced stage at diagnosis and/or suboptimum access to adequate care. Low survival for women living in Ireland/UK and Denmark could indicate late detection, possibly related also to referral delay. Poor survival for ovarian cancer across the continent and over time suggests the need for a major research effort to improve prognosis for this common cancer.",
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AU - Agresti, Roberto

AU - Sánchez Pérez, Maria José

AU - Holleczek, Bernd

AU - Bielska-Lasota, Magdalena

AU - Dimitrova, Nadya

AU - Innos, Kaire

AU - Katalinic, Alexander

AU - Langseth, Hilde

AU - Larrañaga, Nerea

AU - Rossi, Silvia

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N2 - Background Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, vagina and vulva have been documented by previous EUROCARE studies. In the present EUROCARE-5 study we update survival estimates and investigate changes in country-specific and over time survival, discussing their relationship with incidence and mortality dynamics for cancers for which organised screening programs are ongoing. Methods We analysed cases archived in over 80 population-based cancer registries in 29 countries grouped into five European regions. We used the cohort approach to estimate 5-year relative survival (RS) for adult (≥15 years) women diagnosed 2000-2007, by age, country and region; and the period approach to estimate time trends (1999-2007) in RS for breast and cervical cancers. Results In 2000-2007, 5-year RS was 57% overall, 82% for women diagnosed with breast, 76% with corpus uteri, 62% with cervical, 38% with ovarian, 40% with vaginal and 62% with vulvar cancer. Survival was low for patients resident in Eastern Europe (34% ovary-74% breast) and Ireland and the United Kingdom [Ireland/UK] (31-79%) and high for those resident in Northern Europe (41-85%) except Denmark. Survival decreased with advancing age: markedly for women with ovarian (71% 15-44 years; 20% ≥75 years) and breast (86%; 72%) cancers. Survival for patients with breast and cervical cancers increased from 1999-2001 to 2005-2007, remarkably for those resident in countries with initially low survival. Conclusions Despite increases over time, survival for women's cancers remained poor in Eastern Europe, likely due to advanced stage at diagnosis and/or suboptimum access to adequate care. Low survival for women living in Ireland/UK and Denmark could indicate late detection, possibly related also to referral delay. Poor survival for ovarian cancer across the continent and over time suggests the need for a major research effort to improve prognosis for this common cancer.

AB - Background Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, vagina and vulva have been documented by previous EUROCARE studies. In the present EUROCARE-5 study we update survival estimates and investigate changes in country-specific and over time survival, discussing their relationship with incidence and mortality dynamics for cancers for which organised screening programs are ongoing. Methods We analysed cases archived in over 80 population-based cancer registries in 29 countries grouped into five European regions. We used the cohort approach to estimate 5-year relative survival (RS) for adult (≥15 years) women diagnosed 2000-2007, by age, country and region; and the period approach to estimate time trends (1999-2007) in RS for breast and cervical cancers. Results In 2000-2007, 5-year RS was 57% overall, 82% for women diagnosed with breast, 76% with corpus uteri, 62% with cervical, 38% with ovarian, 40% with vaginal and 62% with vulvar cancer. Survival was low for patients resident in Eastern Europe (34% ovary-74% breast) and Ireland and the United Kingdom [Ireland/UK] (31-79%) and high for those resident in Northern Europe (41-85%) except Denmark. Survival decreased with advancing age: markedly for women with ovarian (71% 15-44 years; 20% ≥75 years) and breast (86%; 72%) cancers. Survival for patients with breast and cervical cancers increased from 1999-2001 to 2005-2007, remarkably for those resident in countries with initially low survival. Conclusions Despite increases over time, survival for women's cancers remained poor in Eastern Europe, likely due to advanced stage at diagnosis and/or suboptimum access to adequate care. Low survival for women living in Ireland/UK and Denmark could indicate late detection, possibly related also to referral delay. Poor survival for ovarian cancer across the continent and over time suggests the need for a major research effort to improve prognosis for this common cancer.

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KW - Cervical cancer

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KW - Europe

KW - Ovarian cancer

KW - Population-based

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KW - Vaginal cancer

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