Survival prediction of stage I lung adenocarcinomas by expression of 10 genes

Fabrizio Bianchi, Paolo Nuciforo, Manuela Vecchi, Loris Bernard, Laura Tizzoni, Antonio Marchetti, Fiamma Buttitta, Lara Felicioni, Francesco Nicassio, Pier Paolo Di Fiore

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Adenocarcinoma is the predominant histological subtype of lung cancer, the leading cause of cancer deaths in the world. At stage I, the tumor is cured by surgery alone in about 60% of cases. Markers are needed to stratify patients by prognostic outcomes and may help in devising more effective therapies for poor prognosis patients. To achieve this goal, we used an integrated strategy combining meta-analysis of published lung cancer microarray data with expression profiling from an experimental model. The resulting 80-gene model was tested on an independent cohort of patients using RT-PCR, resulting in a 10-gene predictive model that exhibited a prognostic accuracy of approximately 75% in stage I lung adenocarcinoma when tested on 2 additional independent cohorts. Thus, we have identified a predictive signature of limited size that can be analyzed by RT-PCR, a technology that is easy to implement in clinical laboratories.

Original languageEnglish
Pages (from-to)3436-3444
Number of pages9
JournalJournal of Clinical Investigation
Volume117
Issue number11
DOIs
Publication statusPublished - Nov 1 2007

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Gene Expression
Survival
Lung Neoplasms
Polymerase Chain Reaction
Genes
Meta-Analysis
Cause of Death
Neoplasms
Adenocarcinoma
Theoretical Models
Technology
Adenocarcinoma of lung
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Survival prediction of stage I lung adenocarcinomas by expression of 10 genes. / Bianchi, Fabrizio; Nuciforo, Paolo; Vecchi, Manuela; Bernard, Loris; Tizzoni, Laura; Marchetti, Antonio; Buttitta, Fiamma; Felicioni, Lara; Nicassio, Francesco; Di Fiore, Pier Paolo.

In: Journal of Clinical Investigation, Vol. 117, No. 11, 01.11.2007, p. 3436-3444.

Research output: Contribution to journalArticle

Bianchi, Fabrizio ; Nuciforo, Paolo ; Vecchi, Manuela ; Bernard, Loris ; Tizzoni, Laura ; Marchetti, Antonio ; Buttitta, Fiamma ; Felicioni, Lara ; Nicassio, Francesco ; Di Fiore, Pier Paolo. / Survival prediction of stage I lung adenocarcinomas by expression of 10 genes. In: Journal of Clinical Investigation. 2007 ; Vol. 117, No. 11. pp. 3436-3444.
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