Survival prognostic factors of gastro-enteric-pancreatic neuroendocrine tumors after primary tumor resection in a single tertiary center

Comparison of gastro-enteric and pancreatic locations

N. Russolillo, L. Vigano', P. Razzore, S. Langella, M. Motta, F. Bertuzzo, M. Papotti, A. Ferrero

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim This study aimed to evaluated prognostic factors of patients with GEP-NETs after primary tumor resection comparing pancreatic and gastro-enteric locations. Methods Patients undergone surgery for primary GEP-NETs between 01/2000 and 03/2012 were considered. All specimens were reclassified according to the WHO 2010 scheme. Results A total of 83 patients were considered: 37 pancreatic NETs (pNET) and 46 gastroenteric NETs (GE-NET). The two groups were similar in terms of age, sex and tumors size. A higher rate of patients with pNETs had Ki67 score ≥3 (64.8% vs. 39%, p = 0.027) while the rates of Mitotic Index ≥2x10HPF (62% pNET vs. 50% GE-NET, p = 0.374) and diagnosis of neuroendocrine carcinoma NEC (16.2% pNET vs. 17.3% GE-NET, p = 0.100) were similar. The rates of distant metastases (GE-NETs 30.4% vs. p-NETs 29.7%, p = 0.944) and liver metastases (19.5% GE-NET vs. 27% pNET, p = 0.421) were comparable. Radical resection was achieved in a similar proportion in both groups [33 patients (89.1%) pNET vs. 36 (78.2%) GE-NET, p = 0.393]. After a median follow-up of 47.1 months overall 3, 5 and 10-years survival rates of whole patients were 88.1%, 81.2% and 76.7%. There was not difference on 5-years overall survival between pNET (81.4%) and GE-NET (81%, p = 0.901). At multivariate analysis age ≥70 [OR 4.177 (CI 95% 1.26-13.8), p = 0.019] and NEC [OR 5.932 (CI 95% 1.81-19.40), p <0.001] were negative prognostic factors of survival. Conclusion Overall survival of GEP-NET after resection of primary tumors seems to be correlated to patient's age and WHO 2010 staging system but not to primary tumor site.

Original languageEnglish
Pages (from-to)751-757
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume41
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

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Neuroendocrine Tumors
Survival
Neoplasms
Neoplasm Metastasis
Neuroendocrine Carcinoma
Mitotic Index
Multivariate Analysis
Survival Rate
Liver

Keywords

  • Gastro-enteric neuroendocrine tumors
  • Overall survival
  • Pancreatic neuroendocrine tumors
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Surgery
  • Medicine(all)

Cite this

Survival prognostic factors of gastro-enteric-pancreatic neuroendocrine tumors after primary tumor resection in a single tertiary center : Comparison of gastro-enteric and pancreatic locations. / Russolillo, N.; Vigano', L.; Razzore, P.; Langella, S.; Motta, M.; Bertuzzo, F.; Papotti, M.; Ferrero, A.

In: European Journal of Surgical Oncology, Vol. 41, No. 6, 01.06.2015, p. 751-757.

Research output: Contribution to journalArticle

@article{69a3ac56e0e94736ac3684f5b5aa2f17,
title = "Survival prognostic factors of gastro-enteric-pancreatic neuroendocrine tumors after primary tumor resection in a single tertiary center: Comparison of gastro-enteric and pancreatic locations",
abstract = "Aim This study aimed to evaluated prognostic factors of patients with GEP-NETs after primary tumor resection comparing pancreatic and gastro-enteric locations. Methods Patients undergone surgery for primary GEP-NETs between 01/2000 and 03/2012 were considered. All specimens were reclassified according to the WHO 2010 scheme. Results A total of 83 patients were considered: 37 pancreatic NETs (pNET) and 46 gastroenteric NETs (GE-NET). The two groups were similar in terms of age, sex and tumors size. A higher rate of patients with pNETs had Ki67 score ≥3 (64.8{\%} vs. 39{\%}, p = 0.027) while the rates of Mitotic Index ≥2x10HPF (62{\%} pNET vs. 50{\%} GE-NET, p = 0.374) and diagnosis of neuroendocrine carcinoma NEC (16.2{\%} pNET vs. 17.3{\%} GE-NET, p = 0.100) were similar. The rates of distant metastases (GE-NETs 30.4{\%} vs. p-NETs 29.7{\%}, p = 0.944) and liver metastases (19.5{\%} GE-NET vs. 27{\%} pNET, p = 0.421) were comparable. Radical resection was achieved in a similar proportion in both groups [33 patients (89.1{\%}) pNET vs. 36 (78.2{\%}) GE-NET, p = 0.393]. After a median follow-up of 47.1 months overall 3, 5 and 10-years survival rates of whole patients were 88.1{\%}, 81.2{\%} and 76.7{\%}. There was not difference on 5-years overall survival between pNET (81.4{\%}) and GE-NET (81{\%}, p = 0.901). At multivariate analysis age ≥70 [OR 4.177 (CI 95{\%} 1.26-13.8), p = 0.019] and NEC [OR 5.932 (CI 95{\%} 1.81-19.40), p <0.001] were negative prognostic factors of survival. Conclusion Overall survival of GEP-NET after resection of primary tumors seems to be correlated to patient's age and WHO 2010 staging system but not to primary tumor site.",
keywords = "Gastro-enteric neuroendocrine tumors, Overall survival, Pancreatic neuroendocrine tumors, Surgery",
author = "N. Russolillo and L. Vigano' and P. Razzore and S. Langella and M. Motta and F. Bertuzzo and M. Papotti and A. Ferrero",
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T1 - Survival prognostic factors of gastro-enteric-pancreatic neuroendocrine tumors after primary tumor resection in a single tertiary center

T2 - Comparison of gastro-enteric and pancreatic locations

AU - Russolillo, N.

AU - Vigano', L.

AU - Razzore, P.

AU - Langella, S.

AU - Motta, M.

AU - Bertuzzo, F.

AU - Papotti, M.

AU - Ferrero, A.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Aim This study aimed to evaluated prognostic factors of patients with GEP-NETs after primary tumor resection comparing pancreatic and gastro-enteric locations. Methods Patients undergone surgery for primary GEP-NETs between 01/2000 and 03/2012 were considered. All specimens were reclassified according to the WHO 2010 scheme. Results A total of 83 patients were considered: 37 pancreatic NETs (pNET) and 46 gastroenteric NETs (GE-NET). The two groups were similar in terms of age, sex and tumors size. A higher rate of patients with pNETs had Ki67 score ≥3 (64.8% vs. 39%, p = 0.027) while the rates of Mitotic Index ≥2x10HPF (62% pNET vs. 50% GE-NET, p = 0.374) and diagnosis of neuroendocrine carcinoma NEC (16.2% pNET vs. 17.3% GE-NET, p = 0.100) were similar. The rates of distant metastases (GE-NETs 30.4% vs. p-NETs 29.7%, p = 0.944) and liver metastases (19.5% GE-NET vs. 27% pNET, p = 0.421) were comparable. Radical resection was achieved in a similar proportion in both groups [33 patients (89.1%) pNET vs. 36 (78.2%) GE-NET, p = 0.393]. After a median follow-up of 47.1 months overall 3, 5 and 10-years survival rates of whole patients were 88.1%, 81.2% and 76.7%. There was not difference on 5-years overall survival between pNET (81.4%) and GE-NET (81%, p = 0.901). At multivariate analysis age ≥70 [OR 4.177 (CI 95% 1.26-13.8), p = 0.019] and NEC [OR 5.932 (CI 95% 1.81-19.40), p <0.001] were negative prognostic factors of survival. Conclusion Overall survival of GEP-NET after resection of primary tumors seems to be correlated to patient's age and WHO 2010 staging system but not to primary tumor site.

AB - Aim This study aimed to evaluated prognostic factors of patients with GEP-NETs after primary tumor resection comparing pancreatic and gastro-enteric locations. Methods Patients undergone surgery for primary GEP-NETs between 01/2000 and 03/2012 were considered. All specimens were reclassified according to the WHO 2010 scheme. Results A total of 83 patients were considered: 37 pancreatic NETs (pNET) and 46 gastroenteric NETs (GE-NET). The two groups were similar in terms of age, sex and tumors size. A higher rate of patients with pNETs had Ki67 score ≥3 (64.8% vs. 39%, p = 0.027) while the rates of Mitotic Index ≥2x10HPF (62% pNET vs. 50% GE-NET, p = 0.374) and diagnosis of neuroendocrine carcinoma NEC (16.2% pNET vs. 17.3% GE-NET, p = 0.100) were similar. The rates of distant metastases (GE-NETs 30.4% vs. p-NETs 29.7%, p = 0.944) and liver metastases (19.5% GE-NET vs. 27% pNET, p = 0.421) were comparable. Radical resection was achieved in a similar proportion in both groups [33 patients (89.1%) pNET vs. 36 (78.2%) GE-NET, p = 0.393]. After a median follow-up of 47.1 months overall 3, 5 and 10-years survival rates of whole patients were 88.1%, 81.2% and 76.7%. There was not difference on 5-years overall survival between pNET (81.4%) and GE-NET (81%, p = 0.901). At multivariate analysis age ≥70 [OR 4.177 (CI 95% 1.26-13.8), p = 0.019] and NEC [OR 5.932 (CI 95% 1.81-19.40), p <0.001] were negative prognostic factors of survival. Conclusion Overall survival of GEP-NET after resection of primary tumors seems to be correlated to patient's age and WHO 2010 staging system but not to primary tumor site.

KW - Gastro-enteric neuroendocrine tumors

KW - Overall survival

KW - Pancreatic neuroendocrine tumors

KW - Surgery

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