Abstract
The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.
| Original language | English |
|---|---|
| Pages (from-to) | 140-143 |
| Number of pages | 4 |
| Journal | Rejuvenation Research |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 1 2012 |
Fingerprint
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
Cite this
Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J) : Influence of a zinc-enriched environment. / Malavolta, Marco; Basso, Andrea; Piacenza, Francesco; Giacconi, Robertina; Costarelli, Laura; Pierpaoli, Sara; Mocchegiani, Eugenio.
In: Rejuvenation Research, Vol. 15, No. 2, 01.04.2012, p. 140-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J)
T2 - Influence of a zinc-enriched environment
AU - Malavolta, Marco
AU - Basso, Andrea
AU - Piacenza, Francesco
AU - Giacconi, Robertina
AU - Costarelli, Laura
AU - Pierpaoli, Sara
AU - Mocchegiani, Eugenio
PY - 2012/4/1
Y1 - 2012/4/1
N2 - The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.
AB - The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.
UR - http://www.scopus.com/inward/record.url?scp=84860288746&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860288746&partnerID=8YFLogxK
U2 - 10.1089/rej.2011.1261
DO - 10.1089/rej.2011.1261
M3 - Article
VL - 15
SP - 140
EP - 143
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 2
ER -