Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J): Influence of a zinc-enriched environment

Marco Malavolta; Andrea Basso; Francesco Piacenza; Robertina Giacconi; Laura Costarelli; Sara Pierpaoli; Eugenio Mocchegiani

doi:10.1089/rej.2011.1261

Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J): Influence of a zinc-enriched environment

Marco Malavolta, Andrea Basso, Francesco Piacenza, Robertina Giacconi, Laura Costarelli, Sara Pierpaoli, Eugenio Mocchegiani

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article

Abstract

The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.

Original language	English
Pages (from-to)	140-143
Number of pages	4
Journal	Rejuvenation Research
Volume	15
Issue number	2
DOIs	https://doi.org/10.1089/rej.2011.1261
Publication status	Published - Apr 1 2012

Fingerprint

ASJC Scopus subject areas

Ageing
Geriatrics and Gerontology

Cite this

Malavolta, M., Basso, A., Piacenza, F., Giacconi, R., Costarelli, L., Pierpaoli, S., & Mocchegiani, E. (2012). Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J): Influence of a zinc-enriched environment. Rejuvenation Research, 15(2), 140-143. https://doi.org/10.1089/rej.2011.1261

Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J) : Influence of a zinc-enriched environment. / Malavolta, Marco ; Basso, Andrea ; Piacenza, Francesco ; Giacconi, Robertina ; Costarelli, Laura; Pierpaoli, Sara; Mocchegiani, Eugenio.

In: Rejuvenation Research, Vol. 15, No. 2, 01.04.2012, p. 140-143.

Research output: Contribution to journal › Article

@article{c31d153555164659852c89d514f04622,

title = "Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J): Influence of a zinc-enriched environment",

abstract = "The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.",

author = "Marco Malavolta and Andrea Basso and Francesco Piacenza and Robertina Giacconi and Laura Costarelli and Sara Pierpaoli and Eugenio Mocchegiani",

year = "2012",

month = apr

day = "1",

doi = "10.1089/rej.2011.1261",

language = "English",

volume = "15",

pages = "140--143",

journal = "Rejuvenation Research",

issn = "1549-1684",

publisher = "Mary Ann Liebert Inc.",

number = "2",

}

TY - JOUR

T1 - Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J)

T2 - Influence of a zinc-enriched environment

AU - Malavolta, Marco

AU - Basso, Andrea

AU - Piacenza, Francesco

AU - Giacconi, Robertina

AU - Costarelli, Laura

AU - Pierpaoli, Sara

AU - Mocchegiani, Eugenio

PY - 2012/4/1

Y1 - 2012/4/1

N2 - The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.

AB - The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.

UR - http://www.scopus.com/inward/record.url?scp=84860288746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860288746&partnerID=8YFLogxK

U2 - 10.1089/rej.2011.1261

DO - 10.1089/rej.2011.1261

M3 - Article

C2 - 22533418

AN - SCOPUS:84860288746

VL - 15

SP - 140

EP - 143

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

IS - 2

ER -

Access to Document

10.1089/rej.2011.1261