Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J)

Influence of a zinc-enriched environment

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14 Citations (Scopus)

Abstract

The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalRejuvenation Research
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 1 2012

Fingerprint

Metallothionein
Transgenic Mice
Zinc
Inbred C57BL Mouse
Genetic Therapy
Diet
Health
Proteins

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

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abstract = "The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.",
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AU - Malavolta, Marco

AU - Basso, Andrea

AU - Piacenza, Francesco

AU - Giacconi, Robertina

AU - Costarelli, Laura

AU - Pierpaoli, Sara

AU - Mocchegiani, Eugenio

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