Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J): Influence of a zinc-enriched environment

Marco Malavolta, Andrea Basso, Francesco Piacenza, Robertina Giacconi, Laura Costarelli, Sara Pierpaoli, Eugenio Mocchegiani

Research output: Contribution to journalArticlepeer-review

Abstract

The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalRejuvenation Research
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 1 2012

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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