TY - JOUR
T1 - Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J)
T2 - Influence of a zinc-enriched environment
AU - Malavolta, Marco
AU - Basso, Andrea
AU - Piacenza, Francesco
AU - Giacconi, Robertina
AU - Costarelli, Laura
AU - Pierpaoli, Sara
AU - Mocchegiani, Eugenio
PY - 2012/4/1
Y1 - 2012/4/1
N2 - The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.
AB - The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice.
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U2 - 10.1089/rej.2011.1261
DO - 10.1089/rej.2011.1261
M3 - Article
C2 - 22533418
AN - SCOPUS:84860288746
VL - 15
SP - 140
EP - 143
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 2
ER -