Survival to discharge of a cohort of very low birth weight infants born in Lombardy between 1999-2002

L. Gagliardi, M. Agosti, G. Barera, M. L. Caccamo, G. Chirico, G. Compagnoni, M. Maccabruni, S. Martinelli, G. Moro, L. A. Magni, F. Mosca, G. Rondini, S. Santucci, P. Tagliabue, R. Zanini, R. Bellù, A. Cavazza, A. Brunelli, M. Battaglioli, F. TandoiD. Merazzi, D. Cella, G. F. Perotti, M. Pelti, I. Stucchi, F. Frisone, A. Avanzini, P. Bastrenta, G. Iacono, F. Pontiggia, A. Cotta-Ramusino, F. Strano, P. Fontana, M. Franco, L. Rossi, G. Calciolari, G. Citterio, R. Rovelli, A. Poloniato, G. P. Gancia, C. Costato, R. Germani, S. Barp, R. Crossignani, N. Siliprandi, C. Borroni, M. L. Ventura, L. Abbiati, S. Giardinetti, L. Leva, M. Fusi, M. Bellasio

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives. Information on survival until hospital discharge of very low birth weight infants (VLBWI) in Italy is very scant. The aims of this study were to describe the survival rate of a cohort of 2228 VLBWI, reporting data for gestational age and birthweight groups; report the temporal distribution of deaths during hospital stay through life-table analyses; and estimate the probability of survival at various days of postnatal age at different gestational age weeks ("actuarial survival"). Methods. Analysis of the outcome at hospital discharge in a cohort of 2228 VLBWI born between 1999-2002 in Lombardy, referred to 14 neonatal intensive care units participating in the Neonatal Network of the Lombardy Region. Results. Mortality rate was 14.3% overall, varying from 100% mortality at 21 and 22 weeks, to 3% or less from 30 weeks onwards. The risk of dying was 11.9 times greater in infants with birth weight <1000 g (n = 812) than in those with a birth weight of 1000 g or more (n = 1416). At low gestational age, the risk of dying continued for several days after birth, and more than 40% of deaths of infants born at 24-28 weeks occurred after 7 days of life. Conclusions. This study provides estimates of survival for a large cohort of VLBWI, based on a recent and multicenter sample. Life-table analyses and actuarial survival can provide useful information for clinicians involved in parental counselling.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalItalian Journal of Pediatrics
Volume32
Issue number3
Publication statusPublished - 2006

Fingerprint

Very Low Birth Weight Infant
Survival
Gestational Age
Life Tables
Birth Weight
Mortality
Neonatal Intensive Care Units
Italy
Counseling
Length of Stay
Research Design
Survival Rate
Age Groups
Parturition

Keywords

  • Actuarial survival
  • Life-table analysis
  • Mortality
  • Preterm infants
  • Very low birth weight infants

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Gagliardi, L., Agosti, M., Barera, G., Caccamo, M. L., Chirico, G., Compagnoni, G., ... Bellasio, M. (2006). Survival to discharge of a cohort of very low birth weight infants born in Lombardy between 1999-2002. Italian Journal of Pediatrics, 32(3), 169-176.

Survival to discharge of a cohort of very low birth weight infants born in Lombardy between 1999-2002. / Gagliardi, L.; Agosti, M.; Barera, G.; Caccamo, M. L.; Chirico, G.; Compagnoni, G.; Maccabruni, M.; Martinelli, S.; Moro, G.; Magni, L. A.; Mosca, F.; Rondini, G.; Santucci, S.; Tagliabue, P.; Zanini, R.; Bellù, R.; Cavazza, A.; Brunelli, A.; Battaglioli, M.; Tandoi, F.; Merazzi, D.; Cella, D.; Perotti, G. F.; Pelti, M.; Stucchi, I.; Frisone, F.; Avanzini, A.; Bastrenta, P.; Iacono, G.; Pontiggia, F.; Cotta-Ramusino, A.; Strano, F.; Fontana, P.; Franco, M.; Rossi, L.; Calciolari, G.; Citterio, G.; Rovelli, R.; Poloniato, A.; Gancia, G. P.; Costato, C.; Germani, R.; Barp, S.; Crossignani, R.; Siliprandi, N.; Borroni, C.; Ventura, M. L.; Abbiati, L.; Giardinetti, S.; Leva, L.; Fusi, M.; Bellasio, M.

In: Italian Journal of Pediatrics, Vol. 32, No. 3, 2006, p. 169-176.

Research output: Contribution to journalArticle

Gagliardi, L, Agosti, M, Barera, G, Caccamo, ML, Chirico, G, Compagnoni, G, Maccabruni, M, Martinelli, S, Moro, G, Magni, LA, Mosca, F, Rondini, G, Santucci, S, Tagliabue, P, Zanini, R, Bellù, R, Cavazza, A, Brunelli, A, Battaglioli, M, Tandoi, F, Merazzi, D, Cella, D, Perotti, GF, Pelti, M, Stucchi, I, Frisone, F, Avanzini, A, Bastrenta, P, Iacono, G, Pontiggia, F, Cotta-Ramusino, A, Strano, F, Fontana, P, Franco, M, Rossi, L, Calciolari, G, Citterio, G, Rovelli, R, Poloniato, A, Gancia, GP, Costato, C, Germani, R, Barp, S, Crossignani, R, Siliprandi, N, Borroni, C, Ventura, ML, Abbiati, L, Giardinetti, S, Leva, L, Fusi, M & Bellasio, M 2006, 'Survival to discharge of a cohort of very low birth weight infants born in Lombardy between 1999-2002', Italian Journal of Pediatrics, vol. 32, no. 3, pp. 169-176.
Gagliardi, L. ; Agosti, M. ; Barera, G. ; Caccamo, M. L. ; Chirico, G. ; Compagnoni, G. ; Maccabruni, M. ; Martinelli, S. ; Moro, G. ; Magni, L. A. ; Mosca, F. ; Rondini, G. ; Santucci, S. ; Tagliabue, P. ; Zanini, R. ; Bellù, R. ; Cavazza, A. ; Brunelli, A. ; Battaglioli, M. ; Tandoi, F. ; Merazzi, D. ; Cella, D. ; Perotti, G. F. ; Pelti, M. ; Stucchi, I. ; Frisone, F. ; Avanzini, A. ; Bastrenta, P. ; Iacono, G. ; Pontiggia, F. ; Cotta-Ramusino, A. ; Strano, F. ; Fontana, P. ; Franco, M. ; Rossi, L. ; Calciolari, G. ; Citterio, G. ; Rovelli, R. ; Poloniato, A. ; Gancia, G. P. ; Costato, C. ; Germani, R. ; Barp, S. ; Crossignani, R. ; Siliprandi, N. ; Borroni, C. ; Ventura, M. L. ; Abbiati, L. ; Giardinetti, S. ; Leva, L. ; Fusi, M. ; Bellasio, M. / Survival to discharge of a cohort of very low birth weight infants born in Lombardy between 1999-2002. In: Italian Journal of Pediatrics. 2006 ; Vol. 32, No. 3. pp. 169-176.
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title = "Survival to discharge of a cohort of very low birth weight infants born in Lombardy between 1999-2002",
abstract = "Objectives. Information on survival until hospital discharge of very low birth weight infants (VLBWI) in Italy is very scant. The aims of this study were to describe the survival rate of a cohort of 2228 VLBWI, reporting data for gestational age and birthweight groups; report the temporal distribution of deaths during hospital stay through life-table analyses; and estimate the probability of survival at various days of postnatal age at different gestational age weeks ({"}actuarial survival{"}). Methods. Analysis of the outcome at hospital discharge in a cohort of 2228 VLBWI born between 1999-2002 in Lombardy, referred to 14 neonatal intensive care units participating in the Neonatal Network of the Lombardy Region. Results. Mortality rate was 14.3{\%} overall, varying from 100{\%} mortality at 21 and 22 weeks, to 3{\%} or less from 30 weeks onwards. The risk of dying was 11.9 times greater in infants with birth weight <1000 g (n = 812) than in those with a birth weight of 1000 g or more (n = 1416). At low gestational age, the risk of dying continued for several days after birth, and more than 40{\%} of deaths of infants born at 24-28 weeks occurred after 7 days of life. Conclusions. This study provides estimates of survival for a large cohort of VLBWI, based on a recent and multicenter sample. Life-table analyses and actuarial survival can provide useful information for clinicians involved in parental counselling.",
keywords = "Actuarial survival, Life-table analysis, Mortality, Preterm infants, Very low birth weight infants",
author = "L. Gagliardi and M. Agosti and G. Barera and Caccamo, {M. L.} and G. Chirico and G. Compagnoni and M. Maccabruni and S. Martinelli and G. Moro and Magni, {L. A.} and F. Mosca and G. Rondini and S. Santucci and P. Tagliabue and R. Zanini and R. Bell{\`u} and A. Cavazza and A. Brunelli and M. Battaglioli and F. Tandoi and D. Merazzi and D. Cella and Perotti, {G. F.} and M. Pelti and I. Stucchi and F. Frisone and A. Avanzini and P. Bastrenta and G. Iacono and F. Pontiggia and A. Cotta-Ramusino and F. Strano and P. Fontana and M. Franco and L. Rossi and G. Calciolari and G. Citterio and R. Rovelli and A. Poloniato and Gancia, {G. P.} and C. Costato and R. Germani and S. Barp and R. Crossignani and N. Siliprandi and C. Borroni and Ventura, {M. L.} and L. Abbiati and S. Giardinetti and L. Leva and M. Fusi and M. Bellasio",
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volume = "32",
pages = "169--176",
journal = "Italian Journal of Pediatrics",
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TY - JOUR

T1 - Survival to discharge of a cohort of very low birth weight infants born in Lombardy between 1999-2002

AU - Gagliardi, L.

AU - Agosti, M.

AU - Barera, G.

AU - Caccamo, M. L.

AU - Chirico, G.

AU - Compagnoni, G.

AU - Maccabruni, M.

AU - Martinelli, S.

AU - Moro, G.

AU - Magni, L. A.

AU - Mosca, F.

AU - Rondini, G.

AU - Santucci, S.

AU - Tagliabue, P.

AU - Zanini, R.

AU - Bellù, R.

AU - Cavazza, A.

AU - Brunelli, A.

AU - Battaglioli, M.

AU - Tandoi, F.

AU - Merazzi, D.

AU - Cella, D.

AU - Perotti, G. F.

AU - Pelti, M.

AU - Stucchi, I.

AU - Frisone, F.

AU - Avanzini, A.

AU - Bastrenta, P.

AU - Iacono, G.

AU - Pontiggia, F.

AU - Cotta-Ramusino, A.

AU - Strano, F.

AU - Fontana, P.

AU - Franco, M.

AU - Rossi, L.

AU - Calciolari, G.

AU - Citterio, G.

AU - Rovelli, R.

AU - Poloniato, A.

AU - Gancia, G. P.

AU - Costato, C.

AU - Germani, R.

AU - Barp, S.

AU - Crossignani, R.

AU - Siliprandi, N.

AU - Borroni, C.

AU - Ventura, M. L.

AU - Abbiati, L.

AU - Giardinetti, S.

AU - Leva, L.

AU - Fusi, M.

AU - Bellasio, M.

PY - 2006

Y1 - 2006

N2 - Objectives. Information on survival until hospital discharge of very low birth weight infants (VLBWI) in Italy is very scant. The aims of this study were to describe the survival rate of a cohort of 2228 VLBWI, reporting data for gestational age and birthweight groups; report the temporal distribution of deaths during hospital stay through life-table analyses; and estimate the probability of survival at various days of postnatal age at different gestational age weeks ("actuarial survival"). Methods. Analysis of the outcome at hospital discharge in a cohort of 2228 VLBWI born between 1999-2002 in Lombardy, referred to 14 neonatal intensive care units participating in the Neonatal Network of the Lombardy Region. Results. Mortality rate was 14.3% overall, varying from 100% mortality at 21 and 22 weeks, to 3% or less from 30 weeks onwards. The risk of dying was 11.9 times greater in infants with birth weight <1000 g (n = 812) than in those with a birth weight of 1000 g or more (n = 1416). At low gestational age, the risk of dying continued for several days after birth, and more than 40% of deaths of infants born at 24-28 weeks occurred after 7 days of life. Conclusions. This study provides estimates of survival for a large cohort of VLBWI, based on a recent and multicenter sample. Life-table analyses and actuarial survival can provide useful information for clinicians involved in parental counselling.

AB - Objectives. Information on survival until hospital discharge of very low birth weight infants (VLBWI) in Italy is very scant. The aims of this study were to describe the survival rate of a cohort of 2228 VLBWI, reporting data for gestational age and birthweight groups; report the temporal distribution of deaths during hospital stay through life-table analyses; and estimate the probability of survival at various days of postnatal age at different gestational age weeks ("actuarial survival"). Methods. Analysis of the outcome at hospital discharge in a cohort of 2228 VLBWI born between 1999-2002 in Lombardy, referred to 14 neonatal intensive care units participating in the Neonatal Network of the Lombardy Region. Results. Mortality rate was 14.3% overall, varying from 100% mortality at 21 and 22 weeks, to 3% or less from 30 weeks onwards. The risk of dying was 11.9 times greater in infants with birth weight <1000 g (n = 812) than in those with a birth weight of 1000 g or more (n = 1416). At low gestational age, the risk of dying continued for several days after birth, and more than 40% of deaths of infants born at 24-28 weeks occurred after 7 days of life. Conclusions. This study provides estimates of survival for a large cohort of VLBWI, based on a recent and multicenter sample. Life-table analyses and actuarial survival can provide useful information for clinicians involved in parental counselling.

KW - Actuarial survival

KW - Life-table analysis

KW - Mortality

KW - Preterm infants

KW - Very low birth weight infants

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AN - SCOPUS:33751215887

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JO - Italian Journal of Pediatrics

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