Survivina e sclerosi tuberosa complex: Una proteina antiapoptotica espressa dalle cellule neurali dei tuberi cerebrali

Translated title of the contribution: Survivin and tuberous sclerosis complex: An antiapoptotic protein expressed in neurons cells of tubers

R. Chifari, M. P. Canevini, L. Tassi, L. Madaschi, B. Di Stefano, S. Carelli, G. Lo Russo, R. Alfano, S. Bosari, A. Piazzini, L. Caverni, E. Lesma, D. Boccardi, R. Canger, A. Gorio

Research output: Contribution to journalArticle

Abstract

Survivin is a new discovered antiapoptosic protein that regulates cell division and inhibits apoptosis by blocking caspase activation. Since Survivin overexpression occurs in most cancers, we investigated whether Survivin is expressed in hamartomas cells in tuberous sclerosis complex (TSC). Stable overexpression of Survivin accelerate apoptosis. We explored if surviving was expressed in angiolypomas and tubers of patients with TSC disorder. In summary, our results identify an overexpression protein levels in the tubers and angiolypomas, suggesting that survivin could play a role in aberrant cellular proliferation in TSC.

Translated title of the contributionSurvivin and tuberous sclerosis complex: An antiapoptotic protein expressed in neurons cells of tubers
Original languageItalian
Pages (from-to)299-300
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number125-126
Publication statusPublished - Jul 2004

ASJC Scopus subject areas

  • Clinical Neurology

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