TY - JOUR
T1 - Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer
AU - Branca, Margherita
AU - Giorgi, Colomba
AU - Santini, Donatella
AU - Di Bonito, Luigi
AU - Ciotti, Marco
AU - Costa, Silvano
AU - Benedetto, Arrigo
AU - Casolati, Elena A.
AU - Favalli, Cartesio
AU - Paba, Pierluigi
AU - Di Bonito, Paola
AU - Mariani, Luciano
AU - Syrjänen, Stina
AU - Bonifacio, Donatella
AU - Accardi, Luisa
AU - Zanconati, Francesca
AU - Syrjänen, Kari
PY - 2005/7
Y1 - 2005/7
N2 - We analyzed survivin as a marker of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HR-HPV) and a predictor of HPV clearance and disease outcome in cervical cancer in 302 samples (squamous cell carcinomas [SCCs], 150; CIN lesions, 152) by immunohistochemical staining with survivin antibody and HPV testing using polymerase chain reaction. HR-HPV types were associated closely with CIN and SCC. There was a significant linear relationship between grade and intensity of survivin expression (P = .0001). Survivin overexpression also was associated strongly with HR-HPV type (P = .0001). Multivariate regression analysis revealed survivin and p16 INK4a as equally strong independent predictors of HR-HPV. Deregulated survivin expression did not predict clearance or persistence of HR-HPV after treatment of CIN or survival in cervical cancer in univariate (P = .417) or multivariate analysis. After adjustment for HR-HPV, stage, age, and tumor grade in the Cox regression model, only stage (P = .0001) and age (P = .0001) remained independent prognostic predictors. Survivin seems to be an early marker of cervical carcinogenesis. Up-regulated survivin expression was an independent predictor of HR-HPV in cervical lesions, most plausibly explained by its normal transcriptional repression by wild-type p53 being eliminated by HR-HPV E6 oncoprotein.
AB - We analyzed survivin as a marker of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HR-HPV) and a predictor of HPV clearance and disease outcome in cervical cancer in 302 samples (squamous cell carcinomas [SCCs], 150; CIN lesions, 152) by immunohistochemical staining with survivin antibody and HPV testing using polymerase chain reaction. HR-HPV types were associated closely with CIN and SCC. There was a significant linear relationship between grade and intensity of survivin expression (P = .0001). Survivin overexpression also was associated strongly with HR-HPV type (P = .0001). Multivariate regression analysis revealed survivin and p16 INK4a as equally strong independent predictors of HR-HPV. Deregulated survivin expression did not predict clearance or persistence of HR-HPV after treatment of CIN or survival in cervical cancer in univariate (P = .417) or multivariate analysis. After adjustment for HR-HPV, stage, age, and tumor grade in the Cox regression model, only stage (P = .0001) and age (P = .0001) remained independent prognostic predictors. Survivin seems to be an early marker of cervical carcinogenesis. Up-regulated survivin expression was an independent predictor of HR-HPV in cervical lesions, most plausibly explained by its normal transcriptional repression by wild-type p53 being eliminated by HR-HPV E6 oncoprotein.
KW - Apoptosis inhibitor
KW - Cervical cancer
KW - Cervical intraepithelial neoplasia
KW - CIN
KW - High-risk HPV
KW - Human papillomavirus
KW - Prognosis
KW - Survivin
KW - Virus clearance
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U2 - 10.1309/L8BW-F431-WU9A-C8FJ
DO - 10.1309/L8BW-F431-WU9A-C8FJ
M3 - Article
C2 - 15923164
AN - SCOPUS:21744441468
VL - 124
SP - 113
EP - 121
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 1
ER -