Survivin expression in acute leukemias and myelodysplastic syndromes

Rosangela Invernizzi, Erica Travaglino, Monia Lunghi, Catherine Klersy, Paolo Bernasconi, Mario Cazzola, Edoardo Ascari

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed by immunocytochemistry the expression of survivin in bone marrow cells from 36 acute myeloid leukemia (AML) cases, from 98 patients with myelodysplastic syndrome (MDS), and from 41 non hemopathic subjects. Our aim was to evaluate whether abnormalites in survivin expression were associated with peculiar laboratory and clinical findings, altered apoptosis levels or altered proliferative rate. In normal samples survivin was never detectable. It was detected in almost all AML and MDS cases. In AML and in MDS with more than 5% bone marrow blasts survivin levels higher than in RA and RARS were observed (P = 0.04). In MDS a tendential inverse correlation between survivin and TUNEL positivity was identified (P = 0.08), whereas survivin expression was independent of the proliferative rate. Survivin levels did not predict disease progression in MDS; among AML patients treated with intensive polichemotherapy, survivin expression was significantly higher in resistant cases (P = 0.01). Our findings confirm the high incidence of survivin expression in AML. Its abnormal expression also in MDS may play a role in promoting aberrantly increased cell viability and contribute to the altered homeostatic balance between cell growth and cell death.

Original languageEnglish
Pages (from-to)2229-2237
Number of pages9
JournalLeukemia and Lymphoma
Volume45
Issue number11
DOIs
Publication statusPublished - Nov 2004

Keywords

  • Acute leukemia
  • Apoptosis
  • Immunocytochemistry
  • Myelodysplastic syndrome
  • Survivin

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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