Abstract
Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (cART). Corticosteroids and intravenous immunoglobulins alone did not control the disease, which improved after combined treatment with acyclovir and ganciclovir. SS onset in HIV infection and relapses during cART-induced immune reconstitution are consistent with the dysimmune nature of the disease. The response to anti-herpes drugs suggests a viral contribute in this case of SS.
| Original language | English |
|---|---|
| Article number | 22 |
| Journal | AIDS Research and Therapy |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sep 3 2013 |
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ASJC Scopus subject areas
- Virology
- Molecular Medicine
- Pharmacology (medical)
Cite this
Susac's syndrome as HIV-associated immune reconstitution inflammatory syndrome. / Ferretti, Francesca; Gerevini, Simonetta; Colombo, Bruno; Testa, Manuela; Guffanti, Monica; Franciotta, Diego; Bernardi, Gaetano; Lazzarin, Adriano; Cinque, Paola.
In: AIDS Research and Therapy, Vol. 10, No. 1, 22, 03.09.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Susac's syndrome as HIV-associated immune reconstitution inflammatory syndrome
AU - Ferretti, Francesca
AU - Gerevini, Simonetta
AU - Colombo, Bruno
AU - Testa, Manuela
AU - Guffanti, Monica
AU - Franciotta, Diego
AU - Bernardi, Gaetano
AU - Lazzarin, Adriano
AU - Cinque, Paola
PY - 2013/9/3
Y1 - 2013/9/3
N2 - Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (cART). Corticosteroids and intravenous immunoglobulins alone did not control the disease, which improved after combined treatment with acyclovir and ganciclovir. SS onset in HIV infection and relapses during cART-induced immune reconstitution are consistent with the dysimmune nature of the disease. The response to anti-herpes drugs suggests a viral contribute in this case of SS.
AB - Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (cART). Corticosteroids and intravenous immunoglobulins alone did not control the disease, which improved after combined treatment with acyclovir and ganciclovir. SS onset in HIV infection and relapses during cART-induced immune reconstitution are consistent with the dysimmune nature of the disease. The response to anti-herpes drugs suggests a viral contribute in this case of SS.
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UR - http://www.scopus.com/inward/citedby.url?scp=84883643579&partnerID=8YFLogxK
U2 - 10.1186/1742-6405-10-22
DO - 10.1186/1742-6405-10-22
M3 - Article
C2 - 24004690
AN - SCOPUS:84883643579
VL - 10
JO - AIDS Research and Therapy
JF - AIDS Research and Therapy
SN - 1742-6405
IS - 1
M1 - 22
ER -