Susac's syndrome as HIV-associated immune reconstitution inflammatory syndrome

Francesca Ferretti, Simonetta Gerevini, Bruno Colombo, Manuela Testa, Monica Guffanti, Diego Franciotta, Gaetano Bernardi, Adriano Lazzarin, Paola Cinque

Research output: Contribution to journalArticlepeer-review

Abstract

Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (cART). Corticosteroids and intravenous immunoglobulins alone did not control the disease, which improved after combined treatment with acyclovir and ganciclovir. SS onset in HIV infection and relapses during cART-induced immune reconstitution are consistent with the dysimmune nature of the disease. The response to anti-herpes drugs suggests a viral contribute in this case of SS.

Original languageEnglish
Article number22
JournalAIDS Research and Therapy
Volume10
Issue number1
DOIs
Publication statusPublished - Sep 3 2013

ASJC Scopus subject areas

  • Virology
  • Molecular Medicine
  • Pharmacology (medical)

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