Susceptibility markers in normal subjects: A pilot study for the investigation of 2,3,7,8-tetrachlorodibenzo-p-dioxin related diseases

M. T. Landi; P. A. Bertazzi; G. Clark; G. W. Lucier; S. J. Garte; G. Cosma; P. G. Shields; N. E. Caporaso

doi:10.1016/0045-6535(93)90315-V

Susceptibility markers in normal subjects: A pilot study for the investigation of 2,3,7,8-tetrachlorodibenzo-p-dioxin related diseases

M. T. Landi, P. A. Bertazzi, G. Clark, G. W. Lucier, S. J. Garte, G. Cosma, P. G. Shields, N. E. Caporaso

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Studies on dioxin (TCDD) carcinogenicity in humans have yielded conflicting results. One possible explanation of these mixed findings rests on the role of susceptibility factors. We are currently addressing this hypothesis in a case-control study in the Seveso population. In a pilot investigation, a set of susceptibility markers have been measured in 20 healthy volunteers. Ethoxyresorufin-O-Deethylase (EROD) activity was significantly greater in subjects with mutant CYP1a1 genotypes than in homozygous wild type subjects. No difference in mRNA expression was noted. Meat consumption possibly influences this result. Suggestions of an interaction between "mutation" and "TCDD induction" were obtained.

Original language	English
Pages (from-to)	375-381
Number of pages	7
Journal	Chemosphere
Volume	27
Issue number	1-3
DOIs	https://doi.org/10.1016/0045-6535(93)90315-V
Publication status	Published - 1993

Keywords

CYP1a1
Dioxins
Ethoxyresorufin-O-Deethylase
genetic polymorphisms
inducibility
susceptibility markers

ASJC Scopus subject areas

Environmental Science(all)
Environmental Chemistry

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10.1016/0045-6535(93)90315-V

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title = "Susceptibility markers in normal subjects: A pilot study for the investigation of 2,3,7,8-tetrachlorodibenzo-p-dioxin related diseases",

abstract = "Studies on dioxin (TCDD) carcinogenicity in humans have yielded conflicting results. One possible explanation of these mixed findings rests on the role of susceptibility factors. We are currently addressing this hypothesis in a case-control study in the Seveso population. In a pilot investigation, a set of susceptibility markers have been measured in 20 healthy volunteers. Ethoxyresorufin-O-Deethylase (EROD) activity was significantly greater in subjects with mutant CYP1a1 genotypes than in homozygous wild type subjects. No difference in mRNA expression was noted. Meat consumption possibly influences this result. Suggestions of an interaction between {"}mutation{"} and {"}TCDD induction{"} were obtained.",

keywords = "CYP1a1, Dioxins, Ethoxyresorufin-O-Deethylase, genetic polymorphisms, inducibility, susceptibility markers",

author = "Landi, {M. T.} and Bertazzi, {P. A.} and G. Clark and Lucier, {G. W.} and Garte, {S. J.} and G. Cosma and Shields, {P. G.} and Caporaso, {N. E.}",

year = "1993",

doi = "10.1016/0045-6535(93)90315-V",

language = "English",

volume = "27",

pages = "375--381",

journal = "Chemosphere",

issn = "0045-6535",

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T1 - Susceptibility markers in normal subjects

T2 - A pilot study for the investigation of 2,3,7,8-tetrachlorodibenzo-p-dioxin related diseases

AU - Landi, M. T.

AU - Bertazzi, P. A.

AU - Clark, G.

AU - Lucier, G. W.

AU - Garte, S. J.

AU - Cosma, G.

AU - Shields, P. G.

AU - Caporaso, N. E.

PY - 1993

Y1 - 1993

N2 - Studies on dioxin (TCDD) carcinogenicity in humans have yielded conflicting results. One possible explanation of these mixed findings rests on the role of susceptibility factors. We are currently addressing this hypothesis in a case-control study in the Seveso population. In a pilot investigation, a set of susceptibility markers have been measured in 20 healthy volunteers. Ethoxyresorufin-O-Deethylase (EROD) activity was significantly greater in subjects with mutant CYP1a1 genotypes than in homozygous wild type subjects. No difference in mRNA expression was noted. Meat consumption possibly influences this result. Suggestions of an interaction between "mutation" and "TCDD induction" were obtained.

AB - Studies on dioxin (TCDD) carcinogenicity in humans have yielded conflicting results. One possible explanation of these mixed findings rests on the role of susceptibility factors. We are currently addressing this hypothesis in a case-control study in the Seveso population. In a pilot investigation, a set of susceptibility markers have been measured in 20 healthy volunteers. Ethoxyresorufin-O-Deethylase (EROD) activity was significantly greater in subjects with mutant CYP1a1 genotypes than in homozygous wild type subjects. No difference in mRNA expression was noted. Meat consumption possibly influences this result. Suggestions of an interaction between "mutation" and "TCDD induction" were obtained.

KW - CYP1a1

KW - Dioxins

KW - Ethoxyresorufin-O-Deethylase

KW - genetic polymorphisms

KW - inducibility

KW - susceptibility markers

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U2 - 10.1016/0045-6535(93)90315-V

DO - 10.1016/0045-6535(93)90315-V

M3 - Article

AN - SCOPUS:0027246408

VL - 27

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EP - 381

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

IS - 1-3

ER -

Susceptibility markers in normal subjects: A pilot study for the investigation of 2,3,7,8-tetrachlorodibenzo-p-dioxin related diseases

Abstract

Keywords

ASJC Scopus subject areas

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